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Essential Developmental Biology

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Essential Developmental Biology Cover

 

Synopses & Reviews

Publisher Comments:

Developmental biology is at the core of biological science, integrating molecular biology, genetics and anatomy. The past 15 years has seen revolutionary advances not only in our understanding of the processes by which an egg develops into an adult, but also in the application of this knowledge to the areas of reproductive technology, drug development and organ replacement.

Essential Developmental Biology is a concise and well-illustrated treatment of this subject for undergraduates. Assuming no prior knowledge of anatomy and only the basics of cell biology and genetics, the book starts off by introducing the principles and approaches of developmental biology. The second section covers the characteristic development of each of the principal model species used for research and the final chapters are devoted to organ development, predominantly in vertebrates. With an emphasis throughout on the evidence underpinning the main conclusions, this book is suitable as the key text for both introductory and more advanced courses in developmental biology.

  • A new approach to a widely taught subject.

  • Priced for student purchase at approximately half the price of the main competition.

  • Over 200 illustrations, with artwork available free on the Web.

  • Well-known author/media celebrity.

Synopsis:

Essential Developmental Biology is a comprehensive, richly illustrated introduction to developmental biology. Written in a clear and accessible style, the third edition of this popular textbook has been expanded and updated to include:
  • Numerous full color photographs of developmental biology specimens
  • A new concise summary of “How Development Works”
  • New chapters on “Techniques for Studying Organogenesis” and “Applications of Pluripotent Stem Cells”
  • Expanded treatment of human development, tissue renewal, stem cells, growth, aging, and regeneration.

In addition, the accompanying website provides useful materials for both student and instructor, including animated developmental processes and all artwork in downloadable format.

From review of the second edition:

“The second edition is a must have for anyone interested in development biology. New fi ndings in hot fi elds such as stem cells, regeneration, and aging should make it attractive to a wide readership. Overall, the book is concise, well structured, and illustrated. I can highly recommend it.”—Peter Gruss, Max Planck Society

About the Author

PROFESSOR JONATHAN SLACK has worked in London, Oxford and Bath and is currently Director of the Stem Cell Institute at the University of Minnesota, USA. He is a member of the European Molecular Biology Organization and a Fellow of the Academy of Medical Sciences. He has published numerous research papers on developmental biology as well as three other books, of which the most recent is Stem Cells: A Very Short Introduction.

Table of Contents

Preface, ix

About the companion website, xii

Section N: Groundwork, 1

N The excitement of developmental biology, 3

Where the subject came from, 3

Impact of developmental biology, 4

Future impact, 4

Further reading, 5

O How development works, 7

Ultrashort summary, 7

Gametogenesis, 10

Early development, 12

Morphogenetic processes, 19

Growth and death, 23

Further reading, 25

P Approaches to development: developmental genetics, 27

Developmental mutants, 27

Sex chromosomes, 29

Maternal and zygotic, 29

Genetic pathways, 29

Genetic mosaics, 32

Screening for mutants, 33

Cloning of genes, 34

Gain- and loss-of-function experiments, 34

Gene duplication, 38

Limitations of developmental genetics, 39

Further reading, 40

Q Approaches to development: experimental embryology, 42

Normal development, 42

Developmental commitment, 45

Criteria for proof, 51

Further reading, 52

R Approaches to development: cell and molecular biology techniques, 54

Microscopy, 54

Study of gene expression by molecular biology methods, 58

Study of gene expression by in situ methods, 61

Microinjection, 65

Cell-labeling methods, 66

Further reading, 68

Section O: Major model organisms, 71

S Model organisms, 73

The big six, 73

Access and micromanipulation, 75

Genetics and genome maps, 75

Relevance and tempo, 76

Other organisms, 76

Further reading, 78

T Xenopus, 80

Oogenesis, maturation, and fertilization, 80

Normal development, 82

Experimental methods, 87

Processes of regional specification, 92

Inductive interactions, 95

Further reading, 104

U The zebrafish, 106

Normal development, 106

Genetics, 110

Embryological and molecular techniques, 114

Regional specification, 115

Other uses for the zebrafish, 118

Further reading, 120

V The chick, 121

Normal development, 122

Regional specifi cation of the early embryo, 127

Description of organogenesis in the chick, 133

Further reading, 140

NM The mouse, 141

Mammalian fertilization, 141

Normal development, 145

Regional specifi cation, 153

Human early development, 158

Mouse developmental genetics, 159

Other topics in mouse development, 164

Further reading, 169

NN Drosophila, 171

Insects, 171

Normal development, 173

Drosophila developmental genetics, 178

The developmental program, 181

Further reading, 197

NO Caenorhabditis elegans, 198

Adult anatomy, 198

Embryonic development, 200

Analysis of postembryonic development, 208

Further reading, 215

Section 3: Organogenesis, 217

NP Techniques for studying organogenesis and postnatal development, 219

Genetics, 219

Clonal analysis, 223

Tissue and organ culture, 226

Cell separation methods, 228

Further reading, 230

NQ Development of the nervous system, 231

Overall structure and cell types, 231

Anteroposterior patterning of the neural plate, 234

Dorsoventral patterning of the neural tube, 238

Neurogenesis and gliogenesis, 240

The neural crest, 246

Development of neuronal connectivity, 250

Further reading, 257

NR Development of mesodermal organs, 259

Somitogenesis and myogenesis, 259

The kidney, 266

Germ cell and gonadal development, 269

Limb development, 274

Blood and blood vessels, 284

The heart, 287

Further reading, 293

NS Development of endodermal organs, 296

Normal development, 296

Experimental analysis of endoderm development, 301

The pancreas, 307

Further reading, 312

NT Drosophila imaginal discs, 314

Metamorphosis, 314

Disc development, 318

Further reading, 328

Section Q: Growth, regeneration, evolution, 331

NU Tissue organization and stem cells, 333

Types of tissue, 333

Tissue renewal, 336

Stem cells, 339

Further reading, 360

NV Growth, aging and cancer, 362

Growth: control of size and proportion, 362

Aging, 371

Cancer, 374

Further reading, 382

OM Regeneration of missing parts, 384

Distribution of regenerative capacity, 384

Planarian regeneration, 385

Insect limb regeneration, 388

Vertebrate limb regeneration, 390

General properties of regeneration, 399

Further reading, 400

ON Applications of pluripotent stem cells, 401

Cell transplantation therapy, 401

Embryonic stem cells, 403

Personalized pluripotent stem cells, 406

Proposed cell transplantation therapies using pluripotent stem cells, 411

Further reading, 417

OO Evolution and development, 419

Macroevolution, 420

The primordial animal, 424

What really happened in evolution?, 429

Further reading, 438

Appendix: Key molecular components, 440

Genes, 440

Transcription factor families, 442

Signaling systems, 443

Inducing factor families, 445

Cytoskeleton, 449

Cell adhesion molecules, 451

Extracellular matrix components, 452

Further Reading, 452

Glossary, 454

Index, 467

Product Details

ISBN:
9781118542248
Publisher:
Wiley-Blackwell
Subject:
Science : Life Sciences - Evolution
Author:
Slack, Jonathan M. W.
Subject:
Cytology
Subject:
Cell Biology (Life Sciences)
Subject:
Science : Life Sciences - Developmental Biology
Subject:
Science : Life Sciences - Cell Biology
Subject:
Evolution
Subject:
Developmental Biology
Copyright:
Edition Number:
2
Publication Date:
20120921
Binding:
Electronic book text in proprietary or open standard format
Language:
English
Illustrations:
Y
Pages:
496
Dimensions:
250 x 150 x 15 mm 24 oz

Related Subjects

Science and Mathematics » Biology » Cytology and Cell Biology
Science and Mathematics » Biology » Evolution
Science and Mathematics » Biology » General

Essential Developmental Biology
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$ In Stock
Product details 496 pages Wiley-Blackwell - English 9781118542248 Reviews:
"Synopsis" by , Essential Developmental Biology is a comprehensive, richly illustrated introduction to developmental biology. Written in a clear and accessible style, the third edition of this popular textbook has been expanded and updated to include:
  • Numerous full color photographs of developmental biology specimens
  • A new concise summary of “How Development Works”
  • New chapters on “Techniques for Studying Organogenesis” and “Applications of Pluripotent Stem Cells”
  • Expanded treatment of human development, tissue renewal, stem cells, growth, aging, and regeneration.

In addition, the accompanying website provides useful materials for both student and instructor, including animated developmental processes and all artwork in downloadable format.

From review of the second edition:

“The second edition is a must have for anyone interested in development biology. New fi ndings in hot fi elds such as stem cells, regeneration, and aging should make it attractive to a wide readership. Overall, the book is concise, well structured, and illustrated. I can highly recommend it.”—Peter Gruss, Max Planck Society

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