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Design and Analysis of Quality of Life Studies in Clinical Trials, Second Edition

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Design and Analysis of Quality of Life Studies in Clinical Trials, Second Edition Cover

 

Synopses & Reviews

Publisher Comments:

Clinical trials that include the evaluation of health-related quality of life (QoL) issues are becoming more prevalent, yet many scientists remain unaware of the associated measurement and analysis issues. With an overview of design principles, Design and Analysis of Quality of Life Studies in Clinical Trials presents a range of solutions to analytic issues. This new edition reflects recent developments in methodology with expanded coverage of mixture models and an additional dataset example. The book implements examples using up-to-date SAS and R code and incorporates a number of examples from real QoL clinical trials to illustrate design and analysis methods.

Table of Contents

Introduction and examples — Study design and protocol development — Models for longitudinal studies I — Models for longitudinal studies II — Moderation and mediation — Characterization of missing data — Analysis of studies with missing data — Simple imputation — Multiple imputation — Pattern mixture and other mixture models — Random effects dependent dropout — Selection models — Multiple endpoints — Composite endpoints and summary measures — Quality adjusted life-years (QALYs) and Q-TWiST — Analysis plans and reporting results.

Product Details

ISBN:
9781420061185
Publisher:
CRC Press
Subject:
Quality of life
Author:
Fairclough, Diane Lynn
Subject:
Statistics as Topic.
Subject:
Probability & Statistics - General
Subject:
Biostatistics
Subject:
Pharmacology
Subject:
Mathematics | Probability and Statistics
Subject:
main_subject
Subject:
all_subjects
Publication Date:
20100215
Binding:
ELECTRONIC
Language:
English
Pages:
404

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Design and Analysis of Quality of Life Studies in Clinical Trials, Second Edition
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