Now with NEW bonus DVD with 37 chapters and more than 500 brand new images and video clips!

MORE THAN TRUSTED, BEYOND ESSENTIAL . . .

The #1 selling medical textbook worldwide, Harrison's has defined internal medicine for millions of clinicians and students. The new Seventeenth Edition retains Harrison's acclaimed balance of pathobiology, cardinal signs and manifestations of disease, and best approaches to patient management, yet has been massively updated to give you an innovative array of bold new features and content. If ever there was one must-have resource for clinicians and students - this is it!

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• Bonus companion DVD featuring:37 new “e-chapters”; over 500 brand-new radiological, laboratory, and clinical images, including complete atlases; state-of-the-art video clips; an Image Bank of nearly all the illustrations contained in the parent text, and much more
• Expanded, modernized illustration program with more than 800 brand-new, additional illustrations-a 60% increase over the previous edition
• Dozens of brand new chapters on vital topics in medical education and clinical practice: Global Issues in Medicine: Patient Safety and Health Quality; Health Disparities: Atlas of EKGs; Clinical Management of Obesity: Atlas of Hematology: Atlases of Chest, Neurological, and Cardiovascular Radiology, and much more! Also included a complete new Section on biological foundations and emerging clinical applications of regenerative medicine!
• Brand new, reader-friendly text design optimizes the full-color format
• An expanded, innovative focus on global health
• NEW Global Advisory Board comprised of 11 prominent medical experts from Asia, India, Europe, and South America
• Revision of the popular On Line Learning Center, which offers more skill-sharpening self-assessment questions and answers, plus additional case studies for helping you apply Harrison's content to the daily care of patients
• Harrison's related products are available in a full suite of formats to meet all your educational and clinical needs. Harrison's Practice of Medicine is a complete database of more than 700 clinical topics formatted for use at the point of care. The Harrison's Manual of Medicine is one of the most popular and heavily used handbook-sized resources in internal medicine. The Harrison's Self-Assessment and Board Review features more than 1000 board-type cases and questions and highlights the use of Harrison's as a great board prep resouce.

Eugene Braunwald, MD, Harvard Medical School, Boston, MA.

Dennis L. Kasper, MD, Harvard Medical School, Boston, MA.

Stephen L. Hauser, MD, University of California, San Francisco, CA.

Dan L. Longo, MD, National Institute of Health, Betheseda, MD.

J. Larry Jameson, MD, PhD, Northwestern University, Feinberg School of Medicine, Chicago, IL.

Joseph Loscalzo, MD, PhD, Harvard Medical School, Boston, MA.

Contributors

Preface

Part 1

Introduction to Clinical Medicine

1 The Practice of MedicineThe Editors

2 Global Issues in Medicine Jim Yong Kim / Paul Farmer

3 Decision-Making in Clinical MedicineDaniel B. Mark

4 Screening and Prevention of DiseasesGary J. Martin

5 Principles of Clinical PharmacologyDan M. Roden

6 Womens HealthAndrea Dunaif

7 Medical Disorders during PregnancyRobert L. Barbieri / John T. Repke

8 Medical Evaluation of the Surgical PatientWei C. Lau / Kim A. Eagle

9 Geriatric MedicineLisa B. Caruso / Rebecca A. Silliman

10 Complementary and Alternative MedicineStephen E. Straus

11 Palliative and End-of-Life CareEzekiel J. Emanuel / Joshua Hauser / Linda L. Emanuel

e1 The Safety and Quality of Health CareDavid W. Bates

e2 Economic Considerations in the Practice of MedicineDavid Meltzer

e3 Racial and Ethnic Disparities in Health CareJoseph R. Betancourt / David Blumenthal

e4 Ethical Issues in Clinical MedicineBernard Lo

Part 2

Cardinal Manifestations and Presentation of Diseases

Section 1

Pain

12 Pain: Pathophysiology and Management Howard L. Fields / Joseph B. Martin

13 Chest Discomfort Thomas H. Lee

14 Abdominal PainWilliam Silen

15 HeadachePeter J. Goadsby / Neil H. Raskin

16 Back and Neck PainJohn W. Engstrom

Section 2

Alterations in Body Temperature

17 Fever and HyperthermiaCharles A. Dinarello / Reuven Porat

18 Fever and RashElaine T. Kaye / Kenneth M. Kaye

e5 Atlas of Rashes Associated with FeverElaine T. Kaye / Kenneth M. Kaye

19 Fever of Unknown OriginJeffery A. Gelfand / Michael V. Callahan

20 Hypothermia and FrostbiteDaniel F. Danzl

Section 3

Nervous System Dysfunction

21 SyncopeMark D. Carlson

22 Dizziness and VertigoRobert B. Daroff

23 Weakness and ParalysisMichael J. Aminoff

24 Gait and Balance DisordersLewis Sudarsky

25 Numbness, Tingling, and Sensory LossMichael J. Aminoff / Arthur K.Asbury

26 Confusion and DeliriumS. Andrew Josephson / Bruce L. Miller

e6 Memory LossThomas D. Bird / Bruce L. Miller

27 Aphasia, Memory Loss, and Other Focal Cerebral DisordersM.-Marsel Mesulam

28 Sleep DisordersCharles A. Czeisler / John W. Winkleman / Gary S. Richardson

Section 4

Disorders of Eyes, Ears, Nose, and Throat

29 Disorders of the EyeJonathan C. Horton

30 Disorders of Smell, Taste, and HearingAnil K. Lalwani

31 Pharyngitis, Sinusitis, Otitis, and Other Upper Respiratory InfectionsMichael A. Rubin / Ralph Gonzales / Merle A. Sande

32 Oral Manifestations of DiseaseSamuel C. Durso

e7 Atlas of Oral Manifestations of DiseaseSamuel C. Durso / Janet A. Yellowitz

Section 5

Alterations in Circulatory and Respiratory Functions

33 Dyspnea and Pulmonary Edema Richard M. Schwartzstein

34 Cough and HemoptysisSteven E. Weinberger / David A. Lipson

35 Hypoxia and CyanosisEugene Braunwald

36 EdemaEugene Braunwald / Joseph Loscalzo

e8 Approach to the Patient with a Heart MurmurPatrick OGara / Eugene Braunwald

37 PalpitationsJoseph Loscalzo

Section 6

Alterations in Gastrointestinal Function

38 DysphagiaRaj K. Goyal

39 Nausea, Vomiting, and IndigestionWilliam L. Hasler

40 Diarrhea and ConstipationMichael Camilleri / Joseph A. Murray

41 Weight LossCarol M. Reife

42 Gastrointestinal BleedingLoren Laine

43 JaundiceDaniel S. Pratt / Marshall M. Kaplan

44 Abdominal Swelling and AscitesRobert M. Glickman / Roshini Rajapaksa

Section 7

Alterations in Renal and Urinary Tract Function

45 Azotemia and Urinary AbnormalitiesBradley M. Denker / Barry M. Brenner

e9 Atlas of Urinary Sediments and Renal BiopsiesAgnes B. Fogo / Eric G. Neilsen

46 Fluid and Electrolyte DisturbancesGary G. Singer / Barry M. Brenner

47 Hypercalcemia and HypocalcemiaSundeep Khosla

48 Acidosis and AlkalosisThomas B. DuBose, Jr.

Section 8

Alterations in Sexual Function and Reproduction

49 Sexual DysfunctionKevin T. McVary

50 Hirsutism and VirilizationDavid A. Ehrmann

51 Menstrual Disorders and Pelvic PainJanet E. Hall

Section 9Alterations in the Skin

52 Approach to the Patient with a Skin DisorderThomas J. Lawley / Kim B. Yancey

53 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin DisordersCalvin O. McCall / Thomas J. Lawley

54 Skin Manifestations of Internal DiseaseJean L. Bolognia / Irwin M. Braverman

55 Immunologically Mediated Skin DiseasesKim B. Yancey / Thomas J. Lawley

56 Cutaneous Drug ReactionsJean-Claude Roujeau / Robert S. Stern / Bruce C. Wintroub

57 Photosensitivity and Other Reactions to LightDavid R. Bickers

e10 Atlas of Skin Manifestations of Internal DiseaseThomas J. Lawley / Stephen Templeton

Section 10

Hematologic Alterations

58 Anemia and PolycythemiaJohn W. Adamson / Dan L. Longo

59 Bleeding and ThrombosisBarbara A. Konkle

60 Enlargement of Lymph Nodes and SpleenPatrick H. Henry / Dan L. Longo

61 Disorders of Granulocytes and MonocytesSteven M. Holland /John I. Gallin

e11 Atlas of Hematology and Analysis of Peripheral Blood SmearsDan L. Longo

Part 3Genetics and Disease

62 Principles of Human GeneticsJ. Larry Jameson / Peter Kopp

63 Chromosome DisordersTerry Hassold / Stuart Schwartz

64 The Practice of Genetics in Clinical MedicineSusan Miesfeldt / J. Larry Jameson

65 Gene Therapy in Clinical MedicineKatherine A. High

Part 4

Regenerative Medicine

66 Stem Cell BiologyMinoru S. H. Ko

67 Applications of Stem Cell Biology in Clinical MedicineJack A. Kessler

68 Hematopoietic Stem CellsDavid T. Scadden / Dan L. Longo

69 Tissue EngineeringJennifer Anderson /Joseph P. Vacanti

Part 5

Nutrition

70 Nutritional Requirements and Dietary AssessmentJohanna Dwyer

71 Vitamin and Trace Mineral Deficiency and ExcessRobert M. Russell / Paolo M. Suter

72 Malnutrition and Nutritional AssessmentDouglas C. Heimburger

73 Enteral and Parenteral Nutrition TherapyBruce R. Bistrian / David F. Driscoll

74 Biology of ObesityJeffrey S. Flier / Eleftheria Maratos-Flier

75 Evaluation and Management of ObesityRobert F. Kushner

76 Eating DisordersB. Timothy Walsh

Part 6

Oncology and Hematology

Section 1

Neoplastic Disorders

77 Approach to the Patient with CancerDan L. Longo

78 Prevention and Early Detection of CancerOtis W. Brawley / Barnett S. Kramer

79 Cancer GeneticsPat J. Morin / Jeffrey M. Trent / Francis S. Collins / Bert Vogelstein

80 Cancer Cell Biology and AngiogenesisRobert G. Fenton / Dan L. Longo

81 Principles of Cancer TreatmentEdward A. Sausville / Dan L. Longo

82 Infections in Patients with CancerRobert Finberg

83 Cancer of the Skin Arthur J. Sober / Hensin Tsao / Carl V. Washington

84 Head and Neck Cancer Everett E. Vokes

85 Neoplasms of the Lung John D. Minna / Joan H. Schiller

86 Breast CancerMarc E. Lippman

87 Gastrointestinal Tract CenterRobert J. Mayer

88 Tumors of the Liver and Biliary TreeBrian I. Carr

89 Pancreatic CancerYu Jo Chua / David Cunningham

90 Bladder and Renal Cell CarcinomasHoward I. Scher / Robert J. Motzer

91 Benign and Malignant Diseases of the ProstateHoward I. Scher

92 Testicular CancerRobert J. Motzer / George J. Bosl

93 Gynecologic MalignanciesRobert C. Young

94 Soft Tissue and Bone Sarcomas and Bone MetastasesShreyaskumar R. Patel / Robert S. Benjamin

95 Carcinoma of Unknown PrimaryGauri R. Varadhachary /James L. Abbruzzese

96 Paraneoplastic Syndromes: Endocrinologic/HematologicJ. Larry Jameson / Bruce E. Johnson

97 Paraneoplastic Neurologic SyndromesJoseph Dalmau / Myrna R. Rosenfeld

e12 ThymomaDan L. Longo

e13 Late Consequences of Cancer and Its TreatmentMichael C. Perry / Dan L. Longo

Section 2

Hematopoietic Disorders

98 Iron Deficiency and Other Hypoproliferative AnemiasJohn W. Adamson

99 Disorders of HemoglobinEdward J. Benz

100 Megaloblastic AnemiaA. Victor Hoffbrand

101 Hemolytic Anemias and Anemias due to Acute Blood LossLucio Luzzatto

102 Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure SyndromesNeal S. Young

103 Polycythemia Vera and Other Myeloproliferative DiseasesJerry L. Spivak

104 Acute and Chronic Myeloid LeukemiaMeir Wetzler /John C. Byrd / Clara D. Bloomfield

105 Malignancies of Lymphoid CellsDan L. Longo

106 Plasma Cell DisordersNikhil C. Munshi / Dan L. Longo / Kenneth C. Anderson

107 Transfusion Biology and TherapyJeffery S. Dzieczkowski / Kenneth C. Anderson

108 Hematopoietic Cell TransplantationFrederick R. Applebaum

Section 3

Disorders of Hemostasis

109 Disorders of Platelets and Vessel WallBarbara A. Konkle

110 Coagulation DisordersValder Arruda / Katherine High

111 Thrombosis VenousF.R. Rosendaal / H.R. Büller

112 Antiplatelet, Anticoagulant, and Fibrinolytic DrugsJeffery L. Weitz

Part 7

Infectious Diseases

Section 1

Basic Considerations in Infectious Diseases

113 Introduction to Infectious Diseases: Host-Pathogen InteractionsLawrence C. Madoff / Dennis L. Kasper

114 Molecular Mechanisms of Microbial PathogenesisGerald B. Pier

115 Approach to the Acutely Ill Infected Febrile PatientTamar F. Barlam / Dennis L. Kasper

116 Immunization Principles and Vaccine UseGerald T. Keusch / Kenneth J. Bart / Mark Miller

117 Health Advice for International TravelJ.S. Keystone / P.E. Kozarsky

e14 Laboratory Diagnosis of Infectious DiseasesAlexander J. McAdam / Andrew B. Onderdonk

Section 2

Clinical Syndromes: Community-Acquired Infections

118 Infective EndocarditisAdolf W. Karchmer

119 Infections of the Skin, Muscle, and Soft TissuesDennis L. Stevens

120 OsteomyelitisJeffrey Parsonnet

121 Intraabdominal Infections and AbscessesMiriam J. Baron / Dennis L. Kasper

122 Acute Infectious Diarrheal Diseases and Bacterial Food PoisoningJoan R. Butterton / Stephen B. Calderwood

123 Clostridium difficile-Associated Disease, Including Pseudomembranous ColitisDale N. Gerding / Stuart Johnson

124 Sexually Transmitted Infections: Overview and Clinical ApproachKing K. Holmes

e15 Infectious Complications of Bites and BurnsLawrence C. Madoff / Florencia Pereyra

Section 3

Clinical Syndromes: Nosocomial Infections

125 Health Care-Associated InfectionsRobert A. Weinstein

126 Infections in Transplant RecipientsRobert Finberg /Joyce Fingeroth

Section 4

Approach to Therapy for Bacterial Diseases

127 Treatment and Prophylaxis of Bacterial InfectionsGordon L. Archer / Ronald E. Polk

Section 5

Diseases Caused by Gram-Positive Bacteria

128 Pneumococcal InfectionsDaniel M. Musher

129 Staphylococcal InfectionsFranklin D. Lowy

130 Strepococcal and Enterococcal InfectionsMichael R. Wessels

131 Diphtheria and Other Infections Caused by Corynebacteria and Related SpeciesWilliam R. Bishai / Jack R. Murphy

132 Infections Caused by Listeria monocytogenesElizabeth L. Hohmann / Daniel A. Portnoy

133 TetanusElias Abrutyn

134 BotulismElias Abrutyn

135 Gas Gangrene and Other Clostridial InfectionsDennis L. Kasper /Lawrence C. Madoff

Section 6

Diseases Caused by Gram-Negative Bacteria

136 Meningococcal InfectionsLee M. Wetzler

137 Gonococcal InfectionsSanjay Ram / Peter A. Rice

138 Moraxella InfectionsDaniel M. Musher

139 Haemophilus InfectionsTimothy F. Murphy

140 Infections Due to the HACEK Group and Miscellaneous Gram-Negative BacteriaTamar F. Barlam / Dennis L. Kasper

141 Legionella InfectionMiguel Sabria / Victor L. Yu

142 Pertussis and Other Bordetella InfectionsScott A. Halperin

143 Diseases Caused by Gram-Negative Enteric BacilliThomas A. Russo / James R. Johnson

144 Helicobacter Pylori InfectionsJohn C. Atherton / Martin J. Blaser

145 Infections Due to Pseudomonas Species and Related OrganismsReuben Ramphal

146 SalmonellosisDavid A. Pegues / Samuel I. Miller

147 ShingellosisPhilippe Sansonetti / Jean Bergounioux

148 Infections Due to Campylobacter and Related SpeciesMartin J. Blaser

149 Cholera and Other VibriosesMatthew K. Waldor / Gerald T. Keusch

150 BrucellosisMichael J. Corbel / Nicholas J. Beeching

151 TularemiaRichard F. Jacobs / Gordon E. Schutze

152 Plague and Other Yersnia InfectionsDavid T. Dennis / Grant L. Campbell

153 Bartonella Infections, Including Cat-Scratch DiseaseDavid H. Spach / Emily Darby

154 DonovanosisGavin Hart

Section 7

Miscellaneous Bacterial Infections

155 NocardiosisGregory A. Filice

156 ActinomycosisThomas A. Russo

157 Infections Due to Mixed Anaerobic OrganismsDennis L. Kasper / Ronit Cohen-Poradosu

Section 8

Mycobacterial Diseases

158 TuberculosisMario C. Raviglione / Richard J. OBrien

159 Leprosy (Hansens Disease)Robert H. Gelber

160 Nontuberculous MycobacteriaC. Fordham von Reyn

161 Antimycobacterial AgentsRichard J. Wallace / David E. Griffith

Section 9Spirochetal Disease

162 SyphilisSheila A. Lukehart

163 Endemic TreponematosesSheila A. Lukehart

164 LeptospirosisPeter Speelman / Rudy Harkskeerl

165 Relapsing FeverDavid T. Dennis

166 Lyme BorreliosisAllen C. Steere

Section 10Diseases Caused by Rickettsia, Mycoplasma, and Chlamydia

167 Rickettsial DiseasesDavid H. Walker / J. Stephen Dumler / Thomas Marrie

168 Infections Due to MycoplasmasWilliam M. McCormack

169 Chlamydial InfectionsWalter E. Stamm

Section 11

Viral Diseases: General Considerations

170 Medical VirologyFred Wang /Elliott Kieff

171 Antiviral Chemotherapy, Excluding Antiretroviral DrugsLindsey R. Baden / Raphael Dolin

Section 12

Infections Due to DNA Viruses

172 Herpes Simplex VirusesLawrence Corey

73 Varicella-Zoster Virus InfectionsRichard J. Whitley

174 Epstein-Barr Virus Infections, Including Infectious Mononucleosis Jeffery I. Cohen

175 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8Martin S. Hirsch

176 Molluscum Contagiosum, Monkeypox and Other Poxviruses Excluding Smallpox VirusFred Wang

177 Parvovirus InfectionsKevin E. Brown

178 Human Papillomavirus InfectionsRichard C. Reichman

Section 13

Infections Due to DNA and RNA Respiratory Viruses

179 Common Viral Respiratory Infections and Severe Acute Respiratory Syndrome (SARS)Raphael Dolin

180 InfluenzaRaphael Dolin

Section 14

Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses

181 The Human RetrovirusesDan L. Longo /Anthony S. Fauci

182 Human Immunodeficiency Virus Disease: AIDS and Related DisordersAnthony S. Fauci / H. Clifford Lane

Section 15

Infections Due to RNA Viruses

183 Viral GastroenteritisUmesh D. Parashar / Roger I. Glass

184 Enterovirus and Reoviruses InfectionsJeffery I. Cohen

185 Measles (Rubeola)Anne Gershon

186 Rubella (German Measles)Anne Gershon

187 MumpsAnne Gershon

188 Rabies and Other Rhabdovirus InfectionsAlan C. Jackson / Eric C. Johannsen

189 Infections Caused by Arthropod and Rodent-Borne VirusesClarence J. Peters

190 Ebola and Marburg VirusesClarence J. Peters

Section 16

Fungal and Algal Infections

191 Diagnosis and Treatment of Fungal InfectionsJohn E. Edwards

192 HistoplasmosisChadi A. Hage / L. Joseph Wheat

193 CoccidioidomycosisNeil M. Ampel

194 BlastomycosisStanley W. Chapman

195 CryptococcosisArturo Casadevall

196 Candidiasois John E. Edwards

197 AspergillosisDavid W. Denning

198 MucormycosisAlan M. Sugar

199 Miscellaneous Mycoses and Algal InfectionsStanley W. Chapman / Donna C. Sullivan

200 Pneumocystis InfectionA. Geroge Smulian /Peter D. Walzer

Section 17

Protozoal and Helminthic Infections: General Considerations

e16 Laboratory Diagnosis of Parasitic InfectionsSharon L. Reed / Charles E. Davis

201 Agents Used to Treat Parasitic InfectionsThomas A. Moore

e17 Pharmacology of Agents Used to Treat Parasitic Infections Thomas A. Moore

Section 18

Protozoal Infections

202 Ambiasis and Infection with Free-Living AmebasSharon L. Reed

203 MalariaNicholas J. White / Joel G. Breman

204 BabesiosisJeffery Gelfand

e18 Atlas of Blood Smears of Malaria and BabesiosisNicholas J. White / Joel G. Breman

205 LeishmaniasisBarbara L. Herwaldt

206 TrypanosomiasisLouis V. Kirchhoff

207 Toxoplasma InfectionsLloyd H. Kasper

208 Protozoal Intestinal Infections and TrichomoniasisPeter F. Weller

Section 19

Helminthic Infections

209 Trichinella and Other Tissue NematodesPeter F. Weller

210 Intestinal NematodesPeter F. Weller /Thomas B. Nutman

211 Filarial and Related InfectionsPeter F. Weller / Thomas B. Nutman

212 Schistosomiasis and Other Trematode InfectionsAdel A.F. Mahmoud

213 CestodesA. Clinton White, Jr. / Peter F. Weller

Part 8

Bioterrorism and Clinical Medicine

214 MicrobioterrorismH. Clifford Lane / Anthony S. Fauci

215 Chemical BioterrorismCharles G. Hurst / Jonathan Newmark / James A. Romano

216 Radiation BioterrorismZelig A. Tochner / Eli Glatstein

Part 9

Disorders of Cardiovascular System

Section 1

Introduction to Cardiovascular Disorders

217 Basic Biology of the Cardiovascular SystemJoseph Loscalzo / Peter Libby / Eugene Braunwald

218 Epidemiology of Cardiovascular DiseaseThomas A. Gaziano / J. Michael Gaziano

219 Approach to the Patient with Possible Cardiovascular DiseaseEugene Braunwald

Section 2

Diagnosis of Cardiovascular Disorders

220 Physical Examination of the Cardiovascular SystemRobert A. ORourke /Eugene Braunwald

221 ElectrocardiographyAry L. Goldberger

e19 Atlas of ElectrocardiographyAry L. Goldberger

222 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and MRI/CT ImagingRick Nishimura / Raymond J. Gibbons / James F. Glockner /A. Jamil Tajik

e20 Atlas of Noninvasive Cardiac ImagingRick Nishimura

223 Diagnostic Cardiac Catheterization and AngiographyDonald S. Baim

Section 3

Disorders of Rhythm

224 Principles of ElectrophysiologyGordon F. Tomaselli

225 The BradyarrhythmiasGordon F. Tomaselli

226 The TachyarrhythmiasFrancis Marchlinksi

e21 Atlas of Cardiac ArrhythmiasAry L. Goldberger

Section 4

Disorders of the Heart

227 Heart Failure and Cor PulmonaleDouglas L. Mann

228 Cardiac Transplantation and Prolonged Assisted CirculationSharon A. Hunt

229 Congenital Heart Disease in the AdultJohn S. Child

230 Valvular Heart DiseasePatrick OGara / Eugene Braunwald

231 Cardiomyopathy and MyocarditisJoshua Wynne / Eugene Braunwald

232 Pericardial DiseaseEugene Braunwald

233 Tumors and Trauma of the HeartEric H. Awtry / Wilson S. Colucci

234 Cardiac Manifestations of Systemic DiseaseEric H. Awtry / Wilson S. Colucci

Section 5

Vascular Disease

235 The Pathogenesis, Prevention, and Treatment of AtherosclerosisPeter Libby

e22 Atlas of AtherosclerosisPeter Libby

236 The Metabolic SyndromeRobert H. Eckel

237 Ischemic Heart DiseaseElliott M. Antman / Andrew P. Selwyn/ Eugene Braunwald / Joseph Loscalzo

238 Unstable Angina and Non-ST-Elevation Myocardial InfarctionChristopher P. Cannon / Eugene Braunwald

239 ST-Segment Elevation Myocardial InfarctionElliott M. Antman / Eugene Braunwald

240 Percutaneous Coronary InterventionDonald S. Baim

e23 Atlas of Percutaneous RevascularizationDonald S. Baim

241 Hypertensive Vascular DiseaseTed A. Kotchen

242 Diseases of the AortaMark A. Creager / Joseph Loscalzo

243 Vascular Diseases of the ExtremitiesMark A. Creager / Joseph Loscalzo

244 Pulmonary HypertensionStuart Rich

Part 10

Disorders of the Respiratory System

Section 1

Diagnosis of Respiratory Disorders

245 Approach to the Patient with Disease of the Respiratory SystemDavid A. Lipson / Steven E. Weinberger

246 Disturbances of Respiratory FunctionSteven E. Weinberger /Ilene M. Rosen

247 Diagnostic Procedures in Respiratory DiseasesScott Manaker / Steven E. Weinberger

e24 Atlas of Chest ImagingPatricia Kritek / John J. Reilly, Jr.

Section 2

Diseases of the Respiratory System

248 AsthmaPeter J. Barnes

249 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with EosinophiliaJoel N. Kline / Gary W. Hunninghake

250 Environmental Lung DiseaseFrank E. Speizer / John R. Balmes

251 PneumoniaLionel A. Mandell / Richard Wunderink

252 Bronchiectasis and Lung AbscessGregory Tino / Steven E. Weinberger

253 Cystic FibrosisRichard C. Boucher

254 Chronic Obstructive Pulmonary DiseaseJohn J. Reilly, Jr. / Edwin K. Silverman / Steven D. Shapiro

255 Interstitial Lung DiseasesTalmadge E. King, Jr.

256 Deep Venous Thrombosis and Pulmonary ThromboembolismSamuel Z. Goldhaber

257 Disorders of the Pleura and MediastinumRichard W. Light

258 Disorders of VentilationEliot A. Phillipson

259 Sleep ApneaNeil J. Douglas

260 Lung TransplantationElbert P. Trulock

Part 11

Critical Care Medicine

Section 1

Respiratory Critical Care

261 Principles of Critical Care MedicineJohn P. Kress / Jesse B. Hall

262 Acute Respiratory Distress SyndromeBruce D. Levy / Steve D. Shapiro

263 Mechanical Ventilatory SupportEdward P. Ingenito

Section 2

Shock and Cardiac Arrest

264 Approach to the Patient with ShockRonald V. Maier

265 Severe Sepsis and Septic ShockRobert S. Munford

266 Cardiogenic Shock and Pulmonary EdemaJudith S. Hochman / David H. Ingbar

267 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac DeathRobert J. Myerberg / Agustin Castellanos

Section 3

Neurologic Critical Care

268 ComaAllan H. Ropper

269 Neurologic Critical Care, Including Hypoxic-Ischemic Encephalopathy and Subarachnoid HemorrhageJ. Claude Hemphill / Wade S. Smith

Section 4

Oncologic Emergencies

270 Oncologic EmergenciesRasim Gucalp / Janice Dutcher

Part 12

Disorders of the Kidney and Urinary Tract

271 Cellular and Molecular Biology of the KidneyAlfred L. George / Eric G. Neilson

272 Adaptation of the Kidney to Renal InjuryRaymond C. Harris / Eric G. Neilson

273 Acute Renal Failure Kathleen D. Liu / Glenn M. Chertow

274 Chronic Kidney DiseaseJoanne M. Bargman / Karl Skorecki

275 Dialysis in the Treatment of Renal FailureKathleen D. Liu / Glenn M. Chertow

276 Transplantation in the Treatment of Renal FailureCharles B. Carpenter / Edgar L. Milford / Mohamed H. Sayegh

277 Glomerular DiseasesJulia B. Lewis / Eric G. Neilson

278 Polycystic Kidney Disease and Other Inherited Tubular DisordersDavid J. Salant / Parul S. Patel

279 Tubulointerstitial Diseases of the KidneyAlan S. L. Yu / Barry M. Brenner

280 Vascular Injury to the KidneyKamal F. Badr / Barry M. Brenner

281 NephrolithiasisJohn R. Asplin / Fredric L. Coe / Murray J. Favus

282 Urinary Tract Infections, Pyelonephritis, and ProstatitisWalter E. Stamm

283 Urinary Tract ObstructionJulian L. Seifter / Barry M. Brenner

Part 13

Disorders of the Gastrointestinal System

Section 1

Disorders of the Alimentary Tract

284 Approach to the Patient with Gastrointestinal DiseaseWilliam L. Hasler / Chung Owyang

285 Gastrointestinal EndoscopyLouis Michel Wong Kee Song / Mark Topazian

e25 Video Atlas of Gastrointestinal EndoscopyMark Topazian

286 Diseases of the EsophagusRaj. K. Goyal

287 Peptic Ulcer Disease and Related DisordersJohn Del Valle

288 Disorders of AbsorptionHenry J. Binder

289 Inflammatory Bowel DiseaseSonia Friedman / Richard S. Blumberg

290 Irritable Bowel SyndromeChung Owyang

291 Diverticular Disease and Common Anorectal DisordersSusan L. Gearhart

292 Mesenteric Vascular InsufficiencySusan L. Gearhart

293 Acute Intestinal ObstructionSusan L. Gearhart / William Silen

294 Acute Appendicitis and PeritonitisSusan L. Gearhart / William Silen

Section 2

Liver and Biliary Tract Disease

295 Approach to the Patient with Liver DiseaseMarc Ghany /Jay H. Hoofnagle

296 Evaluation of Liver FunctionDaniel S. Pratt / Marshall M. Kaplan

297 The HyperbilirubinemiasAllan W. Wolkoff

298 Acute Viral HepatitisJules L. Dienstag

299 Toxic and Drug-Induced HepatitisJules L. Dienstag

300 Chronic HepatitisJules L. Dienstag

301 Alcoholic Liver DiseaseMark E. Malliard / Michael F. Sorrell

302 Cirrhosis and Its ComplicationsBruce R. Bacon

e26 Atlas of Liver BiopsiesJules L. Dienstag / Atul K. Bhau

303 Genetic, Metabolic, and Infiltrative Diseases Affecting the LiverBruce R. Bacon

304 Liver TransplantationJules L. Dienstag /Raymond T. Chung

305 Diseases of the Gallbladder and Bile DuctsNorton J. Greenberger / Gustav Paumgartner

Section 3

Disorders of the Pancreas

306 Approach to the Patient with Pancreatic DiseasePhillip P. Toskes / Norton J. Greenberger

307 Acute and Chronic PancreatitisNorton J. Greenberger / Phillip P. Toskes

Part 14

Disorders of the Immune System, Connective Tissue, and Joints

Section 1

The Immune System in Health and Disease

308 Introduction to the Immune SystemBarton F. Haynes / Kelly A. Soderberg / Anthony S. Fauci

309 The Major Histocompatability ComplexGerald T. Nepom

310 Primary Immune Deficiency DiseasesMax D. Cooper / Harry W. Schroeder, Jr.

e27 Primary Immunodeficiencies Associated with or Secondary to Other DiseasesMax D. Cooper

Section 2

Disorders of Immune-Mediated Injury

311 Allergies, Anaphylaxis, and Systemic MastocytosisK. Frank Austen

312 Autoimmunity and Autoimmune DiseasesPeter E. Lipsky / Betty Diamond

313 Systemic Lupus ErythematosusBevra Hannahs Hahn

314 Rheumatoid ArthritisPeter E. Lipsky

315 Acute Rheumatoid FeverJonathan R. Carapetis

316 Systemic Sclerosis (Scleroderma) and Related DisordersJohn Varga

317 Sjögrens SyndromeHaralampos M. Moutsopoulos

318 The SpondyloarthritidesJoel D. Taurog

319 The Vasculitis SyndromesCarol A. Langford / Anthony S. Fauci

e28 Atlas of Clinical Imaging of the Vasculitic DiseasesCarol A. Langford / Anthony S. Fauci

320 Behçets SyndromeHaralampos M. Moutsopoulos

321 Relapsing PolychondritisCarol A. Langford /Bruce C. Gilliland

322 SarcoidosisRobert P. Baughman /Elyse E. Lower

323 Familial Mediterranean Fever and Other Hereditary Recurrent FeversDaniel L. Kastner

324 AmyloidosisDavid C. Seldin / Martha Skinner

Section 3

Disorders of the Joints and Adjacent Tissues

325 Approach to Articular and Musculoskeletal DisordersJohn J. Cush / Peter E. Lipsky

326 OsteoarthritisDavid T. Felson

327 Gout and Other Crystal ArthropathiesH. Ralph Schumacher / Lan X. Chen

328 Infectious ArthritisLawrence C. Madoff

329 FibromyalgiaCarol A. Langford /Bruce C. Gilliland

330 Arthritis Associated with Systemic Disease and Other ArthritidesCarol A. Langford / Bruce C. Gilliland

331 Periarticular Disorders of the ExtremitiesCarol A. Langford / Bruce C. Gilliland

Part 15

Endocrinology and Metabolism

Section 1

Endocrinology

332 Principles of EndocrinologyJ. Larry Jameson

333 Disorders of the Anterior Pituitary and HypothalamusShlomo Melmed / J. Larry Jameson

334 Disorders of the NeurohypophysisGary L. Robertson

335 Disorders of the Thyroid GlandJ. Larry Jameson / Anthony P. Weetman

336 Disorders of the Adrenal CortexGordon H. Williams / Robert G. Dluhy

337 PheochromocytomaHartmut P.H. Neumann

338 Diabetes MellitusAlvin C. Powers

339 HypoglycemiaPhillip E. Cryer

340 Disorders of the Testes and the Male Reproductive SystemShalender Bhasin / J. Larry Jameson

341 Disorders of the Ovary and Female Reproductive TractJanet E. Hall

342 The Menopause Transition and Postmenopausal Hormone TherapyJoAnn E. Manson /Shari S. Bassuk

343 Disorders of Sex DevelopmentJohn C. Achermann / J. Larry Jameson

344 Endocrine Tumors of the Gastrointestinal Tract and PancreasRobert T. Jensen

345 Disorders Affecting Multiple Endocrine Neoplasia SyndromesCamillo Jimenez / Robert Gagel

Section 2

Disorders of Bone and Mineral Metabolism

346 Bone and Mineral Metabolism in Health and DiseaseF. Richard Bringhurst / Marie B. Demay / Stephen M. Krane / Henry M. Kronenberg

347 Diseases of the Parathyroid Gland and Other Hyper- and Hypocalcemia DisordersJohn T. Potts, Jr.

348 OsteoporosisRobert Lindsay / Felicia Cosman

349 Paget Disease and Other Dysplasias of BoneMurray J. Favus /Tamara J. Vokes

Section 3

Disorders of Intermediary Metabolism

350 Disorders of Lipoprotein MetabolismDaniel J. Rader / Helen H. Hobbs

351 HemochromatosisLawrie W. Powell

352 The PorphyriasRobert J. Desnik / Kenneth H. Astrin

353 Disorders of Purine and Pyrimidine MetabolismRobert L. Wortmann

354 Wilson DiseaseGeorge J. Brewer

355 Lysosomal Storage DiseaseRobert J. Hopkin / Gregory A. Grabowski

356 Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate MetabolismYuan-Tsong Chen

357 Heritable Disorders of Connective TissueDarwin J. Prockop / Malwina Czarny-Ratajczak

358 Inherited Disoders of Amino Acid Metabolism in AdultsNicola Longo

359 Inherited Defects of Membrane TransportNicola Longo

e29 Atlas of Clinical Manifestations of Metabolic DiseasesJ. Larry Jameson

Part 16

Neurologic Disorders

Section 1

Diagnosis of Neurologic Disorders

360 Mechanisms of Neurologic DisordersStephen Hauser / M. Flint Beal

361 Approach to the Patient with Neurologic DiseaseDaniel H. Lowenstein / Joseph B. Martin / Stephen L. Hauser

362 Neuroimaging in Neurologic DisordersWilliam P. Dillon

e30 Atlas of NeuroimagingAndre Furtado / William P. Dillon

e31 Electrodiagnostic Studies of Nervous System Disorders: EEG and EMGMichael J. Aminoff

e32 Technique of Lumbar PunctureElizabeth Robbins / Stephen L. Hauser

Section 2

Diseases of the Central Nervous System

363 Seizures and EpilepsyDaniel H. Lowenstein

364 Cerebrovascular DiseasesWade S. Smith / Joey English / S. Claiborne Johnston

365 DementiaThomas D. Bird / Bruce L. Miller

366 Parkinsons Disease and Other Extrapyramidal DisordersMahlon R. DeLong / Jorge L. Juncos

367 Hyperkinetic Movement DisordersC. Warren Olanow

368 Ataxic DisordersRoger N. Rosenberg

369 Amyotrophic Lateral Sclerosis and Other Motor Neuron DiseasesRobert H. Brown, Jr.

370 Disorders of the Autonomic Nervous SystemPhillip A. Low / John W. Engstrom

371 Trigeminal Neuralgia, Bells Palsy, and Other Cranial Nerve DisordersM. Flint Beal / Stephen L. Hauser

372 Diseases of the Spinal CordStephen L. Hauser / Allan H. Ropper

373 Concussion and Other Head InjuriesAllan H. Ropper

374 Primary and Metastatic Tumors of the Nervous SystemStephen M. Sagar / Mark A. Israel

375 Multiple Sclerosis and Other Demyelinating DiseasesStephen L. Hauser / Douglas S. Goodin

376 Meningitis, Encephalitis, Brain Abscess,and EmpyemaKaren L. Roos / Kenneth L. Tyler

377 Chronic and Recurrent Meningitis Walter J. Koroshetz / Morton N. Swartz

378 Prion DiseasesStanley B. Prusiner / Bruce L. Miller

Section 3

Nerve and Muscle Disorders

379 Peripheral NeuropathyVinay Chaudhry

380 Guillain-Barre Syndrome and Other Immune-Mediated NeuropathiesSteven L. Hauser / Arthur K. Asbury

381 Mysathenia Gravis and Other Diseases of the Neuromuscular JunctionDaniel B. Drachman

382 An Approach to Muscular Dystrophy and Other Muscle DiseasesRobert H. Brown, Jr. / Anthony A. Amato / Jerry R. Mendell

383 Polymyositis, Dermatomyositis, and Inclusion Body MyositisMarinos C. Dalakas

e33 Special Issues in Inpatient Neurologic ConsultationS. Andrew Josephson / Martin A. Samuels

Section 4

Chronic Fatigue Syndrome

384 Chronic Fatigue SyndromeStephen E. Straus

Section 5

Psychiatric Disorders

385 Biology of Psychiatric DisordersSteve Hyman / Eric Kandel

386 Mental DisodersVictor I. Reus

Section 6

Alcoholism and Drug Dependency

387 Alcohol and AlcoholismMarc A. Schuckit

388 Opioid Drug Abuse and Dependence Mark A. Schuckit

389 Cocaine and Other Commonly Abused DrugsJack H. Medelson / Nancy K. Mello

390 Nicotine AddictionDavid M. Burns

Part 17

Poisoning, Drug Overdose, and Envenomation

e34 Heavy Metal PoisoningHoward Hu

e35 Poisoning and Drug OverdosageChristopher H. Linden / Michael J. Burns / Mark B. Mycyk

391 Disorders Caused by Reptile Bites and Marine Animal ExposuresPaul Auerbach / Robert Norris

e36 Ectoparasite Infestations and Arthropod Bites and StingsRichard J. Pollack / James H. Maguire

International e Chapters

e37 Pulmonary Biomarkers in COPDPeter J. Barnes

e38 Chagas Disease: Recent Advances in Diagnosis and ManagementAndrei C. Sposito / Jose A.F. Ramires

Summaries of Chapters e1 to e36

Appendix

Laboratory Values of Clinical Importance Alexander Kratz / Michael A. Pesce / Daniel J. Fink

Index