A direct spinoff of the Advances in Enzyme Regulation journal this internationally acclaimed series reports progress at the cutting edge in the strategic area of regulation at the molecular level. In an integrated presentation of original papers, leading scientists, Nobel Prize winners and other outstanding experts from many countries review the best research produced each year and evaluate what is newest and what promises to be the most important in clinical and basic investigations.

The volumes serve as guideposts and beacons for investigators in planning research and teaching students in basic and clinical fields of endeavour. These books advance the general front of studies on metabolic regulation and the understanding of the molecular biology of control of gene expression by hormones, drugs and growth factors in cancer cells and in clinical situations of diabetes, inborn errors of metabolism and neoplasia.

Review of Volume 33:

"Careful consideration and planning have been invested in the crafting of this volume, and George Weber may feel well satisfied with the final result ...... the book succeeds in its aim to be a source of information and inspiration, and a laboratory and teaching companion."

--Clinical Oncology

..... the book succeeds in its aim to be a source of information and inspiration, and a laboratory and teaching companion."

--Clinical Oncology

Acknowledgments

List of Participants

Session I. Regulation of Apoptosis

Session II. Enzyme Regulation: Clinical Relevance

Session III. Role of Cellular Localization in Enzyme Regulation

Session IV. Hypoxia and Enzymic Targets

Session V. Regulation of Carbohydrate Enzymes

Session VI. Regulation in the Nucleus

Session VII. Control of Signal Transduction

Session VIII. Regulation of Signaling Pathways

Session IX. Regulation Through Phospholipase

Session X. Regulation Through Phosphoinositide 3-Kinase

Session XI. Enzyme Regulation as Therapeutic Strategy

Session XII. Special Symposium Lecture: Paul Lalalay

Author Index

Subject Index

Contents of Recent Volumes