The complete, fully updated introduction to biochemical and bioprocess engineering.

Bioprocess Engineering, Second Edition is a comprehensive update of the world's leading introductory textbook on biochemical and bioprocess engineering. Drs. Michael L. Shuler and Fikret Kargi review the relevant fundamentals of biochemistry, microbiology, and molecular biology, introducing key principles that enable bioprocess engineers to achieve consistent control over biological activity. This edition reflects powerful advances that are transforming the field, ranging from genetic sequencing to new techniques for producing proteins from recombinant DNA. It introduces techniques with broad application to the production of pharmaceuticals, biologics, and commodities; to medical applications such as tissue engineering and gene therapy; and for solving critical environmental problems. This new edition includes:

• Essential biological basics: microorganism structure and functions, major metabolic pathways, enzymes, microbial genetics, kinetics, and stoichiometry of growth
• New coverage of posttranslational processing of proteins-an essential technique for manufacturing therapeutic proteins
• In-depth coverage of animal cell culture processes
• New coverage of noncarbohydrate metabolism
• Functional genomics and cellular engineering: concepts, techniques, and applications
• Applying bioprocess engineering approaches to biomedical applications
• Nonconventional biological systems applications, including host-vector systems for producing proteins from recombinant DNA
• Extensive coverage of mixed cultures, including advanced wastewater treatment processes
• Expanded coverage of modeling, including models in continuous cultures and cybernetic modeling
• How the rapidly evolving governmental regulatory environment constrains bioprocess design and modification

Bioprocess Engineering, Second Edition makes extensive use of illustrations, examples, and problems, and contains extensive references for further reading as well as a detailed appendix describing traditional bioprocesses.

Shuler (chemical engineering, Cornell U., USA) and Kargi (environmental engineering, Dokuz Eyl<:u>l U., Turkey) present the new edition of a textbook designed to introduce traditional chemical engineers to the essential concepts of bioengineering, the application of engineering principles to design, develop, and analyze processes using biocatalysts. After outlining basic biological concepts, the text discusses such engineering principles as operating considerations for bioreactors for suspension and immobilized cultures; selection, scale-up, operation, and control of bioreactors; and recovery and purification of products. Final chapters focus attention on applications to such non-conventional biological systems as animal and plant cell cultures, genetically engineered organisms, mixed cultures, and medical applications. The book has been updated to reflect recent advances in genome mapping and other technologies.
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DR. MICHAEL L. SHULER is Professor in the School of Chemical Engineering, Cornell University. His areas of research include structured models, heterologous protein expression systems, cell culture analogs for pharmacokinetic models, in-vitro toxicology, plant-cell tissue culture, microbial functional genomics, and bioremediation.

DR. FIKRET KARGI is Professor of Environmental Engineering at Dokuz Eylul University in Ismir, Turkey. His current research includes bioprocessing of wastes for production of commercial products, development of novel technologies for biological treatment of problematic wastewaters, nutrient removal, and novel biofilm reactor development.

Preface to the Second Edition.

Preface to the First Edition.

I. INTRODUCTION.

II. THE BASICS OF BIOLOGY: AN ENGINEER'S PERSPECTIVE.

III. ENGINEERING PRINCIPLES FOR BIOPROCESSES.

IV. APPLICATIONS TO NONCONVENTIONAL BIOLOGICAL SYSTEMS.