Research on 5-hydroxytryptamine (5-HT) has exploded over the past decade and nowhere have the implications been more far-reaching than in psychiatry. Through the introduction of radioligand binding techniques, a bewildering variety of central 5-HT receptors has been revealed, and powerful new families of centrally active drugs have emerged. For example, our understanding of and the treatment for obsessive-compulsive disorder has been transformed in a very few years. This book is the result of a meeting of the Collegium Internationale Neuro-Psychopharmacologicum. Its free-ranging cut and thrust and the many good ideas presented cannot fail to be of interest to neuroscientists, pharmacologists, psychiatrists, and all those who wish to keep abreast of this rapidly moving area of research.

1. Introduction, M. Sandler

2. An Overview of a 5-Hdroxytryptamine Receptor Family, S.J. Peroutka and A.W. Schmidt

3. An Overview of Seratonin Neurochemistry and Neuroanatomy, D.L. Murphy

4. Milacemide: A Neuropsychotropic Glycine Prodrug that Potentiates Serotonergic Activity, M.B.H. Youdim

5. The Inactive Enantiomer of a Noradrenaline Uptake Blocker Reduces 5-HT Synthesis, P.C. Waldmeier and L. Maitre

6. Platelet Serotonin Studies in Affective Disorders: Evidence for a Serotonergic Abnormality? H.Y. Meltzer and R.C. Arora

7. The Role of 5-HT in Migraine: Disentangling the Links With Depression, V. Glover, J. Jarman and M. Sandler

8. The Acute Effect of Monoamine Oxidase Inhibitors on Serotonin Conversion to Melatonin, G.F. Oxenkrug

9. Stimulation of Rat Pineal Melatonin Synthesis By a Single Electroconvulsive Shock: Chronobiological Effect of Antidepressant Therapy, G. F. Oxenkrug, et al.

10. cAMP-Dependent Binding Proteins and Endogenous Phosphorylation After Anti-Depressant Treatment, G. Racagni, et al.

11. Abnormal 5-HT Neuroendocrine Function in Depression: Association or Artifact? P.J. Cowen and I.M. Anderon

12. Experimental Tests of 5-HT Imbalance Theory of Affective Disturbance, J. Deakin

13. Antidepressant Efficacy of 5-HT1A Partial Agonist Drugs, D.S. Robinson

14. Neuroendocrine Serotonergic Challenges in Clinical Research, J.J. Lopez-Ibor, Jr. et al.

15. Serotonin in Anxiety: Evidence From Animal Models, M. Briley and P. Chopin

16. Anxiogenic Effect of the 5-HT1C Agonist m- chlorophenylpiperazine, G. Curzon, G.A. Kennett and P. Whitton

17. Does 5-Hydroxytrptamine Have a Role in Anxiety and the Action of Anxiolytics? M. Palfreyman and J.H. Kehne

18. Serotonin in Obsessive-Compulsive Disorder: A Casual Connection or More Monomania about a Major Monoamine? T. R. Insel

19. Monoamines, Glucose Metabolism, and Impulse Control, M. Linnoila

20. 5-Hydroxytryptamine in the Cntrol of Feeding and its Possible Implications for Appetite Disturbance, G. Curzon

21. d-Flenfuramine and Animal Models of Eating Disorders, B. Guardiola-Lemaitre

22. Disturbance of the 5-Hydroxytryptamine Metabolism in Aging and in Alzheimer's and Vascular Dementias, C. G. Gottfries

23. 5-HT3 Receptor Antagonist and Their Potential in Pschiatric Disorders, M.G. Palfreyman, et al.

24. Atypical Antipsychotic Drugs: The 5HT2/DA2 Ratio, H.Y. Meltzer

25. Closing Remarks, A. Carlsson