A comprehensive survey of established and experimental methods in nucleoside synthesis

This volume presents a comprehensive review of nucleoside synthesis with a uniquely broad perspective. It describes the three principal types of nucleoside-forming reactions–the fusion reaction, the metal salt procedure, and the Hilbert-Johnson reaction–as well as a number of other methods, and presents a broad overview of alternative chemical methods for synthesis.

This comprehensive discussion includes a survey of experimental protocols for nucleoside synthesis, instructions on preparing components for the reaction, and a sampling of precise experimental procedures for the Vorbrüggen glycosylation reaction. Protocols for a variety of Lewis acid catalysts and carbohydrate precursors are also provided.

An exhaustive tabular survey of glycosylation reactions with nucleobases covers approximately twenty years of literature. These tables are designed for quick visual inspection and form a primary literature resource for researchers in the discipline.

Handbook of Nucleoside Synthesis is an essential resource for those working in nucleosides and oligonucleotides. This thoughtful and well-organized volume includes over 1,400 references that serve the knowledgeable researcher’s every need. Those just entering the field will find it to be an indispensable survey of the experimental aspects of nucleoside synthesis.

Providing a comprehensive review of nucleoside synthesis, this book describes various chemical methods for synthesis, emphasizing the three principal types of nucleoside-forming reactions—the fusion reaction, the metal salt procedure, and the Hilbert- Johnson reaction. It includes a survey of experimental protocols for nucleoside synthesis, instructions for preparing components for the reaction, and a sampling for precise experimental procedures. Vorbr<:u>ggen teaches chemistry at the Free University in Berlin. Ruh-Pohlenz is a research scientist.
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"...an insightful and detailed analysisprovides a valuable resource for the practitioner and a solid foundation for those new to nucleoside synthesis." (Journal of Medicinal Chemistry, Vol. 45, No. 4, 2002)

"...contains much more information than one can assemble from a literature search...allows the reader to compare reaction conditions and the outcome of the reaction...the value of the book is considerable increased by the inclusion of experimental details and protocols based on the experience of the authors...highly recommended for everybody interested.... It is expected that this book will become, just like the Vorbruggen reaction itself, a classic in nucleoside chemistry." (Angewandte Chemie International Edition, Vol. 41, No. 9, 2002)

"...a comprehensive review of nucleoside synthesis..." (SciTech Book News, Vol. 26, No. 2, June 2002)

"...clearly written and well-organized...provides excellent coverage of the contemporary methods used in nucleoside chemistry..." (ChemBioChem, Vol 4(5), 2003)

Handbook of Nucleoside Synthesis includes descriptive information regarding the three principal types of nucleoside forming reactions: the Fusion Reaction, the Metal Salt Procedure, and the Hilbert-Johnson Reaction, as well as other miscellaneous methods.

Includes bibliographical references (p. 590-628) and index.

HELMUT VORBRUGGEN is Professor of Chemistry at the Free University in Berlin, Germany.

CARMEN RUH-POHLENZ is Research Scientist at Schering AG in Berlin, Germany.

Foreword.

Preface.

Acknowledgments.

Synthesis of Nucleosides.

Introduction.

Nucleoside Synthesis.

Silyl-Hilbert-Johnson Reaction in the Presence of Friedel-Crafts Catalysts.

Mechanism of Nucleoside Formation in the Presence of Friedel-Crafts Catalysts.

Special Preparations.

Miscellaneous Methods.

Alternative Nucleoside-Forming Reactions.

Experimental Conditions.

Experimental Procedures.

Tabular Survey.

References.

Index.