Microarrays, widely recognized as the next revolution in molecular biology, enable scientists to analyze genes, proteins and other biological molecules on a genomic scale. This emerging technology, used in more than 10,000 laboratories already, is having an enormous impact in all areas of biomedicine and across the agricultural, biotechnology, and pharmaceutical industries. Mark Schena's Microarray Analysis is the first textbook in this revolutionary new field of study.

This comprehensive and multidisciplinary text begins with an introduction to microarray analysis, and explores basic chemistry, biochemistry, and genomics. Separate chapters are devoted to surface chemistry, target and probe preparation, microarray manufacture and detection, and data analysis and modeling. Methodology, cleanroom technology, gene expression profiling, genetic screening and diagnostics, and novel technologies round out this classic textbook. Microarray Analysis provides any science student or professional all the tools required to understand this revolutionary technology.

* Rapidly teaches students the fundamentals of microarrays

* Describes protein microarrays and other rapidly advancing forefronts

* Builds a conceptual foundation for the entire field

* Presents commercial opportunities in microarray science

* Emphasizes the exciting clinical applications of microarrays

Schena (a consultant for biotechnology companies) explains the operations and uses of microarrays, small analytical devices that allow for the rapid and quantitative analysis of gene expression patterns, patient genotypes, drug mechanisms, and disease onset and progression on a genomic scale. He first discusses the historical roots of the technology and explains some of the basics of chemistry and biochemistry needed to understand its operation. Chapters then explore such topics as genes and genomes, microarray surfaces, targets and probes, manufacturing, detection, informatics, methodological architecture, cleanroom technology, gene expression profiling, genetic screening and diagnostics, novel microarray technologies, and commercial opportunities.
Annotation c. Book News, Inc., Portland, OR (booknews.com)

"…ideal for those who are interested in a broad introduction to microarrays, one that describes thing literally from the ground up." (American Journal of Physical Anthropology, August 2004)

"…a valuable addition to the…series…I enjoyed reading the text, as it has been written in an entertaining way, and I strongly recommend the book to everyone interested in this fascinating new field." (Angewandte Chemie International Edition, 2004/43)

"…a rigorous but reader-friendly critique of diverse ways that genome data can be used in academic and industrial research…" (Genetic Engineering News, Vol. 23, No. 13, July 2003)

"...an essential resource for anyone involved in the life sciences...the first textbook treatment of this innovative technique..." (Word Trade)

"...an essential resource for anyone involved in the life sciences...the first textbook treatment of this innovative technique..." (Word Trade)

"...an excellent text...a valuable reference.... If you need to know what microarrays are, how they can be used, how they work, and how you can analyze the data...then this book will provide the insight." (Clinical Chemistry, Vol. 49, No. 6, 2003)

"...a very personal, encyclopedic, diffuse compendium of everything known about microarrays...fun to read...full of information that a working biologist...might be quite interested to learn." (ASM News, Vol. 69, No. 7, 2003)

"...the book is highly recommended as an excellent one stop resource on microarray technology." (Proteomics, October 2003)

Microarrays, widely recognized as the next revolution in molecular biology, enable scientists to analyze genes, proteins and other biological molecules on a genomic scale. This emerging technology, used in more than 10,000 laboratories already, is having an enormous impact in all areas of biomedicine and across the agricultural, biotechnology, and pharmaceutical industries. Mark Schena’ s Microarray Analysis is the first textbook in this revolutionary new field of study.

This comprehensive and multidisciplinary text begins with an introduction to microarray analysis, and explores basic chemistry, biochemistry, and genomics. Separate chapters are devoted to surface chemistry, target and probe preparation, microarray manufacture and detection, and data analysis and modeling. Methodology, cleanroom technology, gene expression profiling, genetic screening and diagnostics, and novel technologies round out this classic textbook. Microarray Analysis provides any science student or professional all the tools required to understand this revolutionary technology.

• Rapidly teaches students the fundamentals of microarrays
• Describes protein microarrays and other rapidly advancing forefronts
• Builds a conceptual foundation for the entire field
• Presents commercial opportunities in microarray science
• Emphasizes the exciting clinical applications of microarrays

Microarray Analysis presents the fundamental principles, history, theory, science, and applications of microarray technology. This book provides comprehensive coverage of this essential technique, from biochemcial principles underlying the technology to examining methodology and a rigorous, critical analysis of the diverse ways genome data can be used in research.

Includes bibliographical references (p. 473-570) and index.

Introduction to microarray analysis — Introduction to chemistry — Basics of biochemistry — Genes and genomes — Microarray surfaces — Targets and probes — Microarray manufacturing — Microarray detection — Microarray informatics — Methodological architecture — Cleanroom technology — Gene expression profiling — Genetic screening and diagnostics — Novel microarray technologies — Commercial opportunities A to Z — Future trends: chips in the clinics.