The nucleus guides the life processes of the cell by directing cellular reproduction, differentiation during development, and metabolism. The study of the structure and function of the nucleus along with its genetic material serves as the foundation for the science of genetics. Principles of Nuclear Structure and Function provides a comprehensive overview of the cell nucleus by illustrating the connection between function and the architecture of the nucleus.

Richly illustrated throughout, each chapter includes an overview, detailed examples, summary points, references, and callout boxes highlighting methods and cutting-edge technology. The appendix provides a useful list of related Web sites. Some of the subjects reviewed within Principles of Nuclear Structure and Function include:

* Nuclear structure, replication, damage, and repair

* Regulation of gene expression

* The cell cycle

* Meiosis and recombination

This timely volume presents functional studies within their proper structural context and is an informative profile of the cell and molecular biology in nuclei and chromatin. For those studying cell biology, along with molecular and cell biologists, geneticists, and reproductive biologists, Principles of Nuclear Structure and Function is a definitive resource.

Visit www.wiley.com/cook for supplementary information, including additional Web resources, downloadable figures, and discussion questions.

For students entering his field and researchers working in it, Cook (cell biology, U. of Oxford) promotes the idea that the key players in the nucleus—the active polymerases—are attached to discrete structures within nuclei. He suggests readers put their own results into his newer structural context and decided whether the alternative provides a better approximation to the truth than the traditional one. He covers principles, structure, replication, transcription, repair, the regulation of gene expression, the cell cycle, and meiosis and recombination.
Annotation c. Book News, Inc., Portland, OR (booknews.com)

"...covers principles, structure, replications, transcription, repair, the regulation of gene expression, the cell cycle, and meiosis and recombination." (SciTech Book News, Vol. 25, No. 3, September 2001)

"Cook's writing is clear, light and at times colloquial, but always exquisitely accurate[...]easy to read and[...]approachable[...]It is an essential book." (Tom Misteli, National Cabcer Institute, NIH (in Journal of Cell Science)

"Peter Cook has written an important book.... It is an essential book." (Journal of Cell Science, Vol. 114, Part 19)

"This book would be very useful for graduate students or postgraduate students entering a field of study related to the nucleus...could also serve as a fine textbook..."(Doody's Health Services)

I liked both the content and the layout of the book. It will be valuable to both the novice and the expert and may serve well as a text for focused graduate classes.--Gwen V. Childs, Ph.D., University of Arkansas for Medical Sciences, Little Rock, AR

Peter Cook presents an eloquent arguement for considering nuclear events from the holistic viewpoint of the particular structures and factories within which the events of transcription, recombination,replication and repair occur. This is a contemporary and well -informed perspective by a thought leader in this reasearch area, and provides a welcome contrast with the more reductionist views presented in most textbooks on this topic.--Alan Wolffe, Sangamo BioSciences, Richmond, California

Visit www.wiley.com/cook for supplementary information, including additional Web resources, downloadable figures, and discussion questions.

Preface.

Acknowledgments.

Some Principles.

Structure.

Replication.

Transcription.

Repair.

Regulation of Gene Expression.

The Cell Cycle.

Meiosis and Recombination.

Appendix I: Some Websites.

Index.