Tionne "T-Boz" Watkins, Lisa "Left Eye" Lopes, and Rozanda "Chilli" Thomas came together in Atlanta, Georgia, in the early 1990s to form TLC, a group that blended hip-hop, dance, and R&B music so successfully that it went on to be one of the bestselling female groups of all time.

This is the story of how Lisa Lopes, the self-proclaimed "crazy" member of TLC, rose above her difficult childhood to attain superstardom. With her funky raps and her vivacious personality, Lisa pursued her dreams and became known as the most energetic member of TLC, who went on to pave the way for many female groups that followed.