The Second edition of Therapeutic Immunologyprovides a thorough and current review of existing and emerging treatments for diseases of immunologic origin with 14 new chapters and 36 new contributors. Editors and contributors who are recognized leaders in their specialties provide current information on the full spectrum of topics related to intervention, including antibodies, cytokines, gene and cell therapies, and vaccines.

The book should prove a valuable reference for all researchers and physicians working in the field of immunologic disease. Practicing clinicians will appreciate the authors' emphasis on the underlying principles behind clinical interventions and discussions of the applications of current research in immunology, molecular biology, and biotechnology. Three sections covering drugs, biologic agents, and maneuvers demonstrate how the latest developments in immunology and biotechnology can provide treatment strategies for many previously incurable diseases.

New edition of a text that addresses therapeutic maneuvers in the management of human diseases of immunologic origin, with an emphasis upon intervention against a background of clinical issues. Austen, Fred S. Rosen, and Terry B. Strom (all affiliated with Harvard Medical School) and Steven J. Burakoff (New York U. School of Medicine) present 45 contributions that cover introductory material, drugs (antimetabolites and radiomimetics, corticosteroids, and anti-inflammatory agents), biologic agents (cytokines, macromolecules, antibody-based therapy, immunotherapy of allergic disease, chimeric protein, vaccines and peptide therapy) and maneuvers (transplantation, cellular and gene therapy, drugs for HIV infection, and other interventions).
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Therapeutic Immunologyis a comprehensive review of the clinical application of the drugs, biologic agents, and procedures used to treat immunologic diseases. It is the only reference that provides current information on antibodies, cytokines, gene and cell therapies, vaccines, and other therapeutic approaches in the managament of immune system disorders. This book will show how immunology has come of age as a clinical discipline and is now able to provide treatment strategies for many previously incurable diseases.

Contributors.

Preface.

Part I: Introduction.

1. Adaptive Immunity. (Emil R. Unanue).

2. Innate Immunity and Instruction of the Adaptive Immune Response. (Douglas T. Fearon).

Part II: Drugs.

3. Cyclophosphamide. (Alfred D. Steinberg).

4. The Purine Antagonists: Azathioprine and Mycophenolate Mofetil. (Nina E. Tolkoff-Rubin and Robert H. Rubin).

5. Methotrexate. (Michael E. Weinblatt).

6. Immunosupression and Immunophilin Binding Agents: Current research and Clinical Applications. (Shairaz Baksh, Jeff Friedman, Steven J. Burakoff, and Barbara E. Bierer).

7. Glucocorticoid Action. (Jeffrey N. Miner and Myles Brown).

8. Cyclooxygenase Inhibitors. (William L. Smith and David L. DeWitt).

9. Antileukotrienes (Leukotriene Modifiers) in the treatment of Asthma. (Jeffrey M. Drazen).

10. Phosphodiesterase Inhibitors. (Nicky Cooper, Mamidipudi Thirumala Krishna, Robrt Gristwood, and Stephen Holgate.

11. Tryptase Inhibitors. (Andrew F. Walls).

12. 5-Aminosalicylic Acid (Mesalamine)and Sulfasalazine. (Richard P. MacDeDermott.

13. Antihistamines (H-Receptor Antagonists). (F. Estelle R. Simons).

Part III: Biologic Agents.

14. Hematopoietic Growth Factors.

15. Cytokines Regulating Immune Inflammation: Interleukin-4, Interleukin-10, and Interleukin-12. (Richard N. Mitchell and Abul K. Abbas).

16. The Interferons: Basic Biology and Therapeutic Potential. (Vijay Shankaran and Robert D. Schreiber)'.

17. Interleukin-2 Immunostimulation. (Kendall A. Smith).

18. A Soluble TNF Receptor-FC Fusion Protein (Etanercept) in the Treatment of Inflammatory Diseases. (Michael b. Widmer, Leslie Garrison, and Kendall M. Mohler).

19. Intravenous Immunoglobulin Therapy. (Francisco A. Bonilla and Raif S. Geha).

20. Therapeutic Inhibition of Complement Actiation with Emphasis on Drugs in Clinical Trails. (Lloyd B. Klickstein, Francis D. Moore, Jr., and John P. Atkinson).

21. Treatment of Angioedema Resulting from C1-Inhibitor Deficiency. A. Thomas Waytes and Fred S. Rosen).

22. Inhibitors of Tumor Necrosis Factor. (Arthur F. Kavanaugh and Peter E. Lipsky).

23. Targeting the IL-2 Receptor with Antibodies or Chimeric Toxins. (Terry B. Strom).

24. Monoclonal Antibodies to CD3. (Lucienne Chatenoud).

25. Anti-IgE: Immunotherapy for Allergic Diseases. (Donald MacGlashan, Jr.).

26. Specific and nonspecific Immunotherapy for Asthma and Allergic Diseases. (M. Larche and A.B. Kay).

27. Treatment o Allergy to Insect Stings. (Martin D. Valentine).

28. The CD28 T-Cell Costimulatory Pathway: Pharmacologic Inhibition and Augmentation. (Carl H. June and Jeffrey A. Ledbetter).

29. Bacterial Vaccines. (Hilde-Kari Guttormsen and Dennis L. Kasper).

30. Viral Vaccines. (Ronald W. Ellis).

31. DNA Vaccines. (Harriet L. Robinson).

32. Blockade of the CD30L/CD40 Pathway. (Leonard Chess).

PART IV: Maneuvers.

33. Renal Transplantation. (Manikkam Suthanthiran and Terry B. Strom).

34. Pancreas Transplantation. (Michael E. Shapiro).

35. Cardiac Transplantation. (Abdallah G. Kfoury, David O. Taylor, and Dale G. Renlund).

36. Lung Transplantation. (Steven J. Mentzer and Scott J. Swanson).

37. Hemopoietic Stem Cell Transplantation. (Voravit Ratanatharanthorn and James L. M. Ferrara).

38. Cell Transplantation. (Luca Inverardi, Alberto Pugliese, and Camillo Ricordi).

39. Liver Transplantation. (Robert Gedaly, James J. Pomposelli, and Roger L. Jenkins).

40. Xenotransplantation. (Tomasz Sablinski, David K. C. Cooper, and David H. Sachs).

41. Cellular Therapy. (Philip D. Greenberg adn Stanley R. Riddell).

42. Genetically Engineered Cancer Vaccines. (Glenn Dranoff).

43. Gene Therapy for Inherited Immunodeficiencies.

44. Plasmapheresis and Immunoadsorption. (Sian Griffin, C. Martin Lockwood, and Charles D. Pusey).

45. Drug Therapy of HIV Infection. (John P. Doweiko and Jerome E. Groopman).

Index.