A best-selling core textbook for medical students taking biochemistry, Marks' Basic Medical Biochemistry links biochemical concepts to physiology and pathophysiology, using hypothetical patient vignettes to illustrate core concepts. Completely updated to include full-color art, expanded clinical notes, and bulleted end-of-chapter summaries, the revised Third Edition helps medical students understand the importance of the patient and bridges the gap between biochemistry, physiology, and clinical care.

A companion Website offers the fully searchable online text, an interactive question bank with 250 multiple-choice questions, animations depicting key biochemical processes, summaries of patients in the book, and a comprehensive list of disorders discussed in the text, with relevant Website links. An image bank is available for faculty.

Section One: FUEL METABOLISM

• 1: Metabolic Fuels and Dietary Components
• 2: The Fed or Absorptive State
• 3: Fasting

Section Two: CHEMICAL AND BIOLOGICAL FOUNDATIONS OF BIOCHEMISTRY

• 4: Water, Acids, Bases, and Buffers
• 5: Structures of the Major Compounds of the Body
• 6: Amino Acids in Proteins
• 7: Structure-Function Relationships in Proteins
• 8: Enzymes as Catalysts
• 9: Regulation of Enzymes
• 10: Relationship between Cell Biology and Biochemistry
• 11: Cell Signaling by Chemical Messengers

Section Three: GENE EXPRESSION AND THE SYNTHESIS OF PROTEINS

• 12: Structure of the Nucleic Acids
• 13: Synthesis of DNA
• 14: Transcription: Synthesis of RNA
• 15: Translation: Synthesis of Proteins
• 16: Regulation of Gene Expression
• 17: Use of Recombinant DNA Techniques in Medicine
• 18: The Molecular Biology of Cancer

Section Four: FUEL OXIDATION AND THE GENERATION OF ATP

• 19: Cellular Bioenergetics: ATP and O₂
• 20: Tricarboxylic Acid Cycle
• 21: Oxidative Phosphorylation and Mitochondrial Function
• 22: Generation of ATP from Glucose: Glycosis
• 23: Oxidation of Fatty Acids and Ketone Bodies
• 24: Oxygen Toxicity and Free Radical Injury
• 25: Metabolism of Ethanol

Section Five: CARBOHYDRATE METABOLISM

• 26: Basic Concepts in the Regulation of Fuel Metabolism by Insulin, Glucagon, and Other Hormones
• 27: Digestion, Absorption, and Transport of Carbohydrates
• 28: Formation and Degradation of Glycogen
• 29: Pathways of Sugar Metabolism: Pentose Phosphate Pathway, Fructose, and Galactose Metabolism
• 30: Synthesis of Glycosides, Lactose, Glycoproteins, and Glycolipids
• 31: Gluconeogenesis and Maintenance of Blood Glucose Levels

Section Six: LIPID METABOLISM

• 32: Digestion and Transport of Dietary Lipids
• 33: Synthesis of Fatty Acids, Triacylglycerols, and the Major Membrane Lipids
• 34: Cholesterol Absorption, Synthesis, Metabolism, and Fate
• 35: Metabolism of the Eicosanoids
• 36: Integration of Carbohydrate and Lipid Metabolism

Section Seven: NITROGEN METABOLISM

• 37: Protein Digestion and Amino Acid Absorption
• 38: Fate of Amino Acid Nitrogen: Urea Cycle
• L39: Synthesis and Degradation of Amino Acids
• 40: Tetrahydrofolate, Vitamin B₁₂, and S-Adenosylmethionine
• 41: Purine and Pyrimidine Metabolism
• 42: Intertissue Relationships in the Metabolism of Amino Acids

Section Eight: TISSUE METABOLISM

• 43: Actions of Hormones Regulating Fuel Metabolism
• 44: The Biochemistry of the Erythrocyte and Other Blood Cells
• 45: Blood Plasma Proteins, Coagulation and Fibrinolysis
• 46: Liver Metabolism
• 47: Metabolism of Muscle at Rest and During Exercise
• 48: Metabolism of the Nervous System
• 49: The Extracellular Matrix and Connective Tissue

Appendix: Answers to Review Questions

Index