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Interviews | November 19, 2009

Dave: IMG Finding John Irving: The Powells.com Interview

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johnirving[Editor's note: The following is a reprint of our 2005 interview with John Irving, whose new novel, Last Night in Twisted River, has just come out... Continue »
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Multiple Drug Resistance in Cancer 2: Molecular, Cellular & Clinical Aspects

by Martin Clynes

Multiple Drug Resistance in Cancer 2: Molecular, Cellular & Clinical Aspects Cover

Synopses & Reviews

Publisher Comments:

Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.

Book News Annotation:

A multi-author volume bringing together new reviews on aspects of our knowledge about drug-resistance mechanisms, with particular attention paid to recently-discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other major topics covered include DNA repair, Topoisomerases, cell cycle control, oxygenation and vascularization of tumors, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps in MDR are also addressed. Of likely use to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair, and apoptosis research. Reprinted from Cytotechnology, v.27, nos.1/3, 1998. No subject index. Annotation c. by Book News, Inc., Portland, OR (booknews@booknews.com)
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Product Details

ISBN:
9780792352723
Subtitle:
Molecular, Cellular and Clinical Aspects
Editor:
Clynes, Martin
Editor:
Clynes, Martin
Publisher:
Springer Netherlands
Location:
Dordrecht
Subject:
Pharmacology
Subject:
Cancer
Subject:
Oncology
Subject:
Neoplasms
Subject:
Drug resistance in cancer cells.
Subject:
Drug Resistance, Multiple.
Subject:
Drug Resistance, Neoplasm.
Edition Number:
2
Edition Description:
Reprinted from
Publication Date:
January 1998
Binding:
Hardcover
Language:
English
Illustrations:
Yes
Pages:
344
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