Demonstrating the relationship of the basic theory of solid-phase extraction (SPE) to chromatography, this comprehensive reference illustrates how SPE techniques significantly contribute to the preparation of samples for a wide variety of analytical techniques. It provides step-by-step details on the applications of SPE to environmental matrices, broad-spectrum drug screening, veterinary drug abuse, pharmaceutical drug development, biological samples, and high-throughput screening. Written by world-renowned experts in the field, the book contains helpful reference charts, tables of solvent properties, selectivities, molecular acid/base properties, and more.

Unlike most scientific techniques, which are developed theoretically then applied in laboratory environments, solid-phase extraction appeared in practice, was fairly common commercially before it even had a name, and has received little scientific or academic attention. To help correct the lack, scholars of chemistry and scientists in pharmaceutical companies from several countries discuss how the basic theory of the method relates to chromatography, and how the procedure can contribute to preparing samples for a wide variety of analytical techniques, including gas chromatography, mass spectrometry, and high- performance liquid chromatographic analysis. Their topics include sorbents and formats, handling large volume samples in environmental matrices, secondary interactions and mixed-mode extractions, applications in veterinary drug abuse, automation, and immuno-affinity extraction.
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Unlike most scientific techniques, which are developed theoretically then applied in laboratory environments, solid-phase extraction appeared in practice, was fairly common commercially before it even had a name, and has received little scientific or academic attention. To help correct the lack, scholars of chemistry and scientists in pharmaceutical companies from several countries discuss how the basic theory of the method relates to chromatography, and how the procedure can contribute to preparing samples for a wide variety of analytical techniques, including gas chromatography, mass spectrometry, and high - performance liquid chromatographic analysis. Their topics include sorbents and formats, handling large volume samples in environmental matrices, secondary interactions and mixed-mode extractions, applications in veterinary drug abuse, automation, and immuno-affinity extraction.

Introduction to solid-phase extraction / Nigel J.K. Simpson and Martha J.M. Wells — SPE sorbents and formats / Joseph J. Pesek and Maria T. Matyska — The sample matrix and its influence on method development / Nigel J.K. Simpson and Paul M. Wynne — Handling large volume samples : applications of SPE to environmental matrices / Martha J.M. Wells — SPE technology--principles and practical consequences / Michael Henry — Theory meets practice / Colin F. Poole and Salwa K. Poole — Secondary interactions and mixed-mode extraction / Brian Law — Solid-phase extraction for broad-spectrum drug screening in toxicological analysis / Rokus R. De Zeeuw and Jan Piet Franke — The application of SPE to veterinary drug abuse / Paul M. Wynne — Solid-phase extraction of biological samples / Steen H. Ingwersen — Solid-phase extraction mediated by covalent bonding : applications of immobilized phenylboronic acid / I.D. Wilson and P. Martin — Immuno-affinity extraction / Derek Stevenson, Badrul A.A. Rashid and Seyyed J. Shahtaheri — Matrix solid-phase dispersion (MSPD) / Steven A. Barker — Automation of solid-phase extraction / Lynn Jordan — Integration of SPE with the analytical technique, part I-liquid chromatography / Nigel J.K. Simpson — Integration of SPE with the analytical technique, part II / Nigel J.K. Simpson — Concluding thoughts--new directions for SPE / Nigel J.K. Simpson.