Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone, or completely derail, important new drug development. Even much-needed reformulation of currently marketed products can be significantly affected by these challenges.

Water Insolubility is the Primary Culprit in over 40% of New Drug Development Failures

The most comprehensive resource on the topic, this second edition of Water Insoluble Drug Formulation brings together a distinguished team of experts to provide the scientific background and step-by-step guidance needed to deal with solubility issues in drug development. Twenty-three chapters systematically describe solubility properties and their impact on formulation, from theory to industrial practice. With detailed discussion on how these properties contribute to solubilization and dissolution, the text also features six brand new chapters on water-insoluble drugs, exploring regulatory aspects, pharmacokinetic behavior, early phase formulation strategies, lipid based systems for oral delivery, modified release of insoluble drugs, and scalable manufacturing aspects. The book includes more than 15 water-insoluble drug delivery systems or technologies, illustrated with case studies featuring oral and parenteral applications. Highlighting the most current information and data available, this seminal volume reflects the significant progress that has been made in nearly all aspects of this field.

The most comprehensive resource on the topic, this second edition brings together a distinguished team of experts to provide the scientific background and step-by-step guidance needed to deal with solubility issues in drug development.

From a world-class team of experts, Water-Insoluble Drug Formulation provides step-by-step guidance and scientific background on drug and water properties, discussing how they contribute to solubilization and dissolution. The second edition features three brand new chapters on regulatory aspects of water-insoluble drugs, water-insoluble drugs and their pharmacokinetic behaviors, and formulation strategies for drug candidates with water-insoluble properties for toxicology, biology, and pharmacology studies in discovery support. This book provides all of the latest information and data, reflecting the significant progress that has been made in nearly all aspects of this field.