Gay Izzy is an erotic cartoonist; his best pal Eve makes exotic jewelry and works as a receptionist in a whorehouse. She collects clippings of unsolved murders of women and has flashes of psychic ability, and he's an aging party boy who's been getting more and more into metaphysical reading and exploring heightened states of mind through S/M sex clubs and a drug called SILT that's permeated the gay community. SILT causes a "shift," which takes one to a different reality. When gay men start disappearing without a trace, and Izzy joins the ranks of the missing, Eve embarks on a mission beyond anything she's over dreamed or imagined. Part edgy thriller, part ghost story, "Izzy and Eve" is a witty and unsettling joyride through Drinnan's acid-etched world.