For over 150 years it is clear that a set of hypercoagulable states should co-exist with the propensity for intravascular clotting in order to display thrombotic tendency. This volume of The Clinics is an interdisciplinary discussion of the recent advances in this field: the recognition that certain situations in womens lives, such as pregnancy, puerperium, and exposure to exogenous hormones qualify as hypercoagulable states; the definition of the nature (genetic and acquired) of this propensity for intravascular (venous or arterial) clottingcurrently termed thrombophilia; the implication that conditions such as recurrent abortions, stillbirth, placental abruption, and preeclampsia may also qualify as thrombophilia-related events; and, finally, the emergence of management guidelines. This state-of-the-art volume is dedicated to the most important hypercoagulable states in womens health and will be of value to caregivers from various disciplines, including obstetrics and gynecology, hematology, neonatology, as well as general practitioners.