These proceedings for a May 2005 conference held in Lucerne by a major pharmaceutical company focuses on advanced drug discovery techniques such as early ADMET (absorption, distribution, metabolism, excretion and toxicity) determination, pharmacodynamic (what the drug does to the organism) and pharmakinetic (what the organism does to the drug) effects. The contributors, who represent industry as well as academia, approach ADMET from the molecules and also from the barriers, with topics such as the benefits and limits of in Silicio predictions, ADME predictions and molecular structure, lipophilicity, interpretation of the electrotopological state and molecular connectivity indices, molecular descriptors for predicting ADMET properties, extracting pharmacophores from bio-active molecules, in Silico models for human bioavailability and models to predict bran uptake, algorithms to predict affinity for transporters, cytochromes P450, expert systems to predict biotransformation and toxicity and future challenges in determining ADMET. Annotation ©2007 Book News, Inc., Portland, OR (booknews.com)