This is a revisionist study of seventeenth- and eighteenth-century satires on science with an emphasis on the writings of Jonathan Swift and, to a lesser degree, Samuel Butler and other satirists. To say, as some literary commentators do, that the satirists attacked only pseudo-scientists who failed to employ the empirical method properly is to beg a crucial question: how could the satirists possibly have distinguished the genuine scientist from the crank? By a failsafe set of Baconian principles perhaps? No, the matter is more complicated. I read the satiric literature on early modern science against a totally different understanding of what science is, how it came into being, and how it developed. Satire has a decided advantage over scientific discourse. It can rely on common sense; scientific discourse often cannot. There is always a counter-intuitive element in the genuinely new. New knowledge is in some ways always at odds with received assumptions of what is possible, reasonable, or probable. Satire on science, I suggest, can be seen as a systematic exploitation of that gap of plausibility. Natural philosophers of the late seventeenth- and early eighteenth-century were keenly aware of their discursive disadvantage and at times even hesitated to publish their material. They feared the satirists and the wits, who they knew would find it easy to debunk their work on commonsense grounds. But commonsense and laughter are unreliable yardsticks for measuring scientific merit. Ironically, the satirists and the natural philosophers shared some of the most fundamental epistemological assumptions of early English empiricism, for instance, the stereotypical Baconian assumption that knowledge about nature would come to us unambiguously once the mind was freed from preconception and bias. It is an assumption about scientific method that is decidedly hostile towards speculative hypothesising. Indeed, the motto of the day was not bold speculation and learning from error, but