Angiogenesis in Health and Disease

Outlines strategies for stimulating capillary formation in hypoxia and ischemia and inhibiting it in cancer, diabetes, and chronic inflammation. This state-of-the-science reference highlights recent progress in the ways to promote formation of new blood vessels in ischemic/hypoxic tissue and the means to stifle capillary growth and development in solid tumors, diabetic retinopathy, and chronic immuno/inflammatory disorders such as rheumatoid arthritis and psoriasis. Emphasizes practical clinical applications derived from the latest angiogenesis research. Written by over 80 leading international experts, Angiogenesis in Health and Disease 7examines new angiogenic regulators such as angiopoietins and TIE-receptors 7describes angiogenic genes such as thymosine B-4, EDG-1, and ARNT proteins 7analyzes the role of vascular endothelial growth factor (VEGF) in capillary sprouting 7investigates behaviors of endogenous agents of angiogenesis, including cytokines, hormones, chemokines, and peptide and hematopoietic growth factors 7explores mechanisms for ameliorating or preventing vascular occlusive disease by induction of collateral artery growth 7explains differences in conditions that prompt angiogenesis and arteriogenesis 7reviews transgenic and knock-out mice, receptor protein mutations, and other emerging technologies 7evaluates angiogenic inhibitors such as angiostatin and endostatin 7and more! Containing over 3000 references, tables, drawings, and photographs, Angiogenesis in Health and Disease deserves a prominent place on the bookshelves of cardiologists, oncologists, physiologists, hematologists, molecular and cell biologists, biochemists, pharmacologists, rheumatologists, vascularsurgeons, and upper-level undergraduate, graduate, and medical school students in these disciplines.

Dozens of scientists from the US, Europe, and Israel, have contributed to this text, highlighting recent research in ways to promote formation of new blood vessels in ischemic/hypoxic tissue as well as how to prevent capillary growth in solid tumors, diabetic retinopathy, and chronic immuno-inflammatory disorders. B&w photographs, sketches, and tables provides visual illustrations in many of the articles, which cover topics such as the role of vascular endothelial growth factor in capillary sprouting, the differences in conditions that prompt angiogenesis and anteriogenesis, and evaluates angiogenic inhibitors such as angiostatin and endostatin.
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