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Coalescent Theory: An Introduction

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Coalescent Theory: An Introduction Cover

 

Synopses & Reviews

Book News Annotation:

At the heart of the move toward interdisciplinary scholarship, particularly within the field of genetics, this form of study combines tenets of both biology and mathematics. Wakeley (Harvard U.) approaches coalescent theory primarily from the biological end, and assumes most readers are biologists, but gives full due to the mathematical argument without losing non-experts. He describes the concepts behind gene genealogies, include genealogical thinking, mutation and mutation models, measures of DNA polymorphism and, by way of example, variation at the pyruvate dehydrogenase E1 alpha (or PDHA1) subunit. He then gives the fundamentals of probability theory and Poisson processes, moving to the population genetic models and the standard coalescent model, properties of coalescent genealogies, neutral genetic variation, the structured coalescent, separation of time scales, ancestral graphs, simulations and inference. The result is remarkably accessible, given the complexity of both approach and content. Annotation ©2008 Book News, Inc., Portland, OR (booknews.com)

Synopsis:

Coalescent theory provides the foundation for molecular population genetics and genomics. It is the conceptual framework for studies of DNA sequence variation within species, and is the source of essential tools for making inferences about mutation, recombination, population structure and natural selection from DNA sequence data.

About the Author

John Wakeley is Professor and Chairman of Biology at Harvard University. He has worked extensively in coalescent theory. His research has focussed on populations structured by geography and limited migration. Using coalescent models, Dr. Wakeley has addressed questions about the current and historical demography of humans and other species.

Table of Contents

1. Gene Genealogies

2. Probability Theory

3. The Coalescent

4. Neutral Genetic Variation

5. The Structured Coalescent

6. Separation of Time Scales

7. Ancestral Graphs

8. Simulations and Inference

Bibliography

Index

Product Details

ISBN:
9780974707754
Author:
Wakeley, John
Publisher:
Roberts & Company Publishers
Author:
John, Wakeley
Subject:
Life Sciences - Evolution
Subject:
Genetics
Subject:
Mathematical models
Subject:
Life Sciences - Genetics & Genomics
Subject:
Biostatistics
Subject:
Genetics -- Mathematical models.
Subject:
Biology-Genetics
Subject:
Evolution
Edition Description:
1st Edition
Publication Date:
20080631
Binding:
TRADE PAPER
Language:
English
Illustrations:
Y
Pages:
432
Dimensions:
7.5 x 10.1 x 0.9 in 1.8 lb

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Science and Mathematics » Biology » Evolution
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Product details 432 pages Roberts & Company Publishers - English 9780974707754 Reviews:
"Synopsis" by ,

Coalescent theory provides the foundation for molecular population genetics and genomics. It is the conceptual framework for studies of DNA sequence variation within species, and is the source of essential tools for making inferences about mutation, recombination, population structure and natural selection from DNA sequence data.

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