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Regulatory T Cells and Clinical Applicationby Shuiping Jiang
Synopses & Reviews
A major process of rediscovery has taken place in the field of Cellular Immunology over the past 12 years--subsets of T lymphocytes exist that are specifically dedicated to regulation or as it should be more appropriately termed suppression of all aspects of immune responses. It was only after Prof. Sakaguchi identified the CD25 antigen in 1995 as a marker for a major population of T cells that had suppressor functions both in vitro and in vivo that the resurgence in the regulatory T cell area could begin. The regulatory T cells field has grown dramatically over the past decade. It is now impossible to read a journal that does not contain numerous papers whose titles deal with regulatory T cells. More importantly, it is also difficult to submit a new research grant proposal in any area of immunologic research that does not include a section on analysis on the contribution of regulatory T cells to the subject matter under study. Regulatory T cells can be best thought of today as "teenagers" ready to take on all the challenges of complex immune responses. In ten years, the field will certainly be more mature, and manipulation of regulatory T cell function by cellular biotherapy, antibodies and small molecules will be routine function of the clinical immunologist. - From Preface by Prof. Ethan Shevach, National Institute of Health, USA It has been for long debated whether suppressor/regulatory T cells did actually even exist. Today, this question is no longer accurate and the subject of regulatory T cells is the object of a constantly growing interest in immunologists and clinicians. There is no doubt that the history of Tregs will make a new big leap ahead. - From Chapter One by Prof. Shimon Sakaguchi, Kyoto University, Japan
Covering one of the hottest topics in immunology today, this book provides a comprehensive view of all types of regulatory T cells described so far in the literature. The book will have broad appeal to both researchers and clinicians.
The immune system reacts vigorously to foreign invaders such as viruses, bacteria, protozoa, and parasites, and yet shows unresponsiveness to our own proteins. Immune tolerance to self-proteins is paramount to prevent the development of autoimmune disease. In the past decade, several types of T lymphocytes in the immune system have been discovered to function as regulatory cells to suppress unwanted immune responses to self-proteins, leading to the protection of autoimmunity. Furthermore, regulatory T cells also protect us from the development of asthma allergy, and prevent organ transplantation rejection. Regulatory T Cells and Clinical Application provides a comprehensive view of all types of regulatory T cells described so far in the literature. By thoroughly reviewing the immunobiology of regulatory T cells and their implications in various forms of human diseases, a new perspective of therapy using regulatory T cells as individualized medicine to treat inflammatory diseases including diabetes, allergy and transplantation rejection is highlighted. About the Editor: Dr. Shuiping Jiang is a British Heart Foundation Fellow in the Department of Nephrology and Transplantation at Guy's Hospital, King's College London, United Kingdom.
Table of Contents
Preface by Ethan M. Shevach, National Institute of Health, USA.- Part One: Immunobiology of Regulatory T Cells.- Regulatory T cells and the control of auto-immunity: from day 3 thymectomy to FoxP3+ regulatory T cells by Makoto Miyara and Shimon Sakaguchi, Kyoto University, Japan.- FoxP3 and regulatory T cells by Karsten Kretschmer, Irina Apostolou, Panos Verginis and Harald von Boehmer, Harvard University.- Thymic and peripheral generation of CD4+CD25+FoxP3+ regulatory T cells by Paola Romagnoli, Julie Ribot, Julie Tellier and Joost P.M. van Meerwij, INSERM, France.- The role of IL-2 in the development and peripheral homeostasis of naturally occurring CD4+CD25+Foxp3+ regulatory T cells by Allison L. Bayer and Thomas R. Malek, University of Miami, USA.- IL-2 signaling and CD4+CD25+ regulatory T cells by Louise M. D'Cruz and Ludger Klein, University of Vienna, Austria.- TGF-b and regulatory T cells by Yisong Y. Wan and Richard Flavell, Yale University, USA.- TGF-b controls reciprocal differentiation of CD4+CD25+FoxP3+ regulatory T cells and IL-17 producing Th17 cells from naïve CD4+CD25- T cells by Wanjun Chen, National Institute of Health, USA.- Molecular signalling in regulatory T cells (by Natasha R. Locke, Natasha K. Crellin and Megan K. Levings, University of British Columbia, Canada.- Part Two: Regulatory T Cells in Disease and Clinical Application.- CD4+FoxP3+ regulatory T cells in immune tolerance by Ciriaco A. Piccirillo, McGill University, Canada.- Regulatory T cell control of autoimmune diabetes and their potential therapeutic application by Qizhi Tang and Jeffrey A. Bluestone, University of California at San Francisco, USA.- CD4+CD25+ regulatory T cells as adoptive cell therapy for autoimmune disease and for the treatment of graft-versus-host disease by Swati Acharya and C. Garrison Fathman, Stanford University, USA.- Natural CD4+CD25+ regulatory T cells in regulation of autoimmune disease by Adam P. Kohm and Stephen D. Miller, Northwestern University, USA.- Multiple sclerosis and regulatory T cells by Jonathon Hutton, Clare Baecher-Allan and David A. Hafler, Harvard University, USA.- CD4+CD25+ regulatory T cells and TGF-b in mucosal inflammation by M. Fantini and Markus F. Neurath, University of Mainz, Germany.- Induction of adaptive CD4+CD25+FoxP3+ Regulatory T cell response for autoimmune disease by Jian Hong, Sheri Skinner and Jingwu Zhang, Shanghai Institutes of Biological Sciences, China.- Regulatory T cells in transplantation by Kathryn J Wood, Andrew Bushell, Manuela Carvalho-Gaspar, Gang Feng, Ross Francis, Nick Jones, Elaine Long, Shiqiao Luo, Ian Lyons, Satish Nadig, Birgit Sawitzki, Gregor Warnecke, Bin Wei and Joanna Wieckiewicz, University of Oxford, the UK.- Regulatory T-cells in therapeutic transplantation tolerance by Herman Waldmann, Elizabeth Adams, Paul Fairchild and Stephen Cobbold, University of Oxford, the UK.- CD4+CD25+ regulatory T cell therapy for the induction of clinical transplantation tolerance by David S. Game, Robert I. Lechler and Shuiping Jiang, King's College London, the UK.- Regulatory T cells in allergic disease by Catherine Hawrylowicz, King's College London, the UK.- Regulatory T cells and tumour immunotherapy by Ilona Kryczek and Weiping. Zou, University of Michigan, USA.- Regulatory T cells in hepatitis and hepatocellular carcinoma by Fu-Sheng Wang and George F. Gao, Beijing Institute of Infectious Diseases, China.- CD4+CD25+ regulatory T cells in viral infections by Wayne A. Tompkins, Mary B. Tompkins, Angela M. Mexas and Jonathan E. Fogle, North Carolina State University, USA.- IL-10 and TGF-b-producing regulatory T cells in infection by P. J. Dunne, A. G. Rowan, J. M. Fletcher and Kingston H. G. Mills, Trinity College, Ireland.- Human type 1 T regulatory cells by Manuela Battaglia, Silvia Gregori, Rosa Bacchetta and Maria Grazia Roncarolo, San Raffaele Institute, Italy.- CD8+ regulatory T cells in eye derive tolerance by Joan Stein-Streilein and Hiroshi Keino, Harvard University, USA.- Immune suppression by a novel population of CD8aa+TCRab+ regulatory T cells by Trevor R. F. Smith and Vipin Kumar, Torrey Pines Institute for Molecular Studies, USA.- Innate regulatory iNKT cells by Dalam Ly and Terry L. Delovitch, Robarts Research Institute, Canada.- Natural killer T cells regulate the development of asthma by Muriel Pichavant, Rosemarie H. DeKruyff, and Dale T. Umetsu, Harvard University, USA.- The development, activation, function and mechanisms of immunosuppressive double negative (DN) T cells by Megan S. Ford and Li Zhang, University of Toronto, Canada.- gd T cells in immunoregulation by Long Tang, Ning Kang and Wei He, Chinese Academy of Medical Sciences, China.-
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