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Mouse Development: Patterning, Morphogenesis, and Organogenesisby Janet Rossant
Synopses & Reviews
This book represents a classic compilation of current knowledge about mouse development and its correlates to research in cell biology, molecular biology, genetics, and neuroscience. Emphasis is placed on the research strategy, experimental design, and critical analysis of the data, disguishing this from other books that only focus on protocols for mouse developmental research. Selected chapters are indexed to electronic databases such as GeneBank, GenBank, Electronic Mouse Atlas, and Transgenic/Knockout, further increasing the utility of this book as a reference.
*Broad-based overview of mouse development from fundamental to specialist levels
*Extensive coverage of a wide range of developmental mutations of the mouse
*Excellent benchmark illustrations of brain, craniofacial, gut and heart development
*In-depth experiment-based assessment of concepts in mammalian development
*Focus on models of specific relevance to human development
*Comprehensive reference to key literature and electronic databases related to mouse development
*High-quality full-color production
Book News Annotation:
Offers an overview of contemporary research in the molecular and cellular aspects of mouse embryonic development. It addresses embryological experimentation, particularly in early embryonic patterning, inductive interactions, and organogenesis. Written by experts in mammalian development, the 23 chapters cover topics including asymmetry and prepattern in mammalian development; left-right asymmetry; segmentation of the paraxial mesoderm and the delineation of tissue compartments; germ cells; vasculogenesis and angiogenesis; development of the endoderm and its tissue derivatives; sex determination and differentiation; craniofacial development; development of the mouse inner ear; and integumentary structures. Color and b&w illustrations throughout.
Annotation c. Book News, Inc., Portland, OR (booknews.com)
e beginning to explore the mouse as a model system for studying vertebrate development and its relevance to human disease. The mouse is becoming increasingly attractive as the major model system for the functional annotation of mammalian genome. This book provides a broad-based introductory research-based text for investigators who may be interested in incorporating the mouse into their research endeavors.
This book is an overview of contemporary research in the molecular and cellular aspects of mouse embryonic development. It showcases how embryological experimentation is shedding light on issues of early embryonic patterning, inductive interactions and organogenesis. The authors are all experts in mammalian development and each chapter provides an introductory overview of the field as well as more detailed current research findings.
This book is aimed at investigators, from graduate students to senior scientists, who are beginning to explore the mouse as a model system for studying vertebrate development and its relevance to human disease. The mouse is becoming increasingly attractive as the major model system for the functional annotation of mammalian genome. This book provides a broad-based introductory research-based text for investigators who may be interested in incorporating the mouse into their research endeavors.
About the Author
Patrick Tam received his Ph.D. in theoretical physics from Cornell University and is a professor of physics at Humboldt State University. He is an associate editor of Mathematica in Education and Research, and his papers have appeared in Computers in Physics and The Physics Teacher. He has given numerous invited talks on Mathematica, and has been the leader of many Mathematica workshops for the American Association of Physics Teachers and a two-week computer algebra workshop supported by a National Science Foundation faculty enhancement grant. He has served as a Mathematica consultant for Wolfram Research, Inc. and Carleton College.
Department of Physics, Humboldt State University, Arcata, CA, USA
Table of Contents
Establishment of Body Pattern
Fertilization and Activation of the Embryonic Genome
Asymmetry and Pre-Pattern in Mammalian Development
Anterior Posterior Patterning of the Mouse Body Axis at Gastrulation
Patterning, Regionalization and Cell Differentiation in the Forebrain
Establishment of Anterior-Posterior and Dorsal-Ventral Pattern in the Early Central Nervous System
Somitogenesis: Segmentation of the Paraxial Mesoderm and the Delineation of Tissue Compartments
II. Lineage Specification and Differentiation
Development of the Vertebrate Hematopoetic System
Vasculogenesis and Angiogenesis
Stem Cells of the Nervous System
Cellular and Molecular Mechanisms Regulating Skeletal Muscle Development
Chondrogenesis and Skeletogenesis
Development of the Endoderm and its Tissue Derivatives
Heart Development: Induction, Myogenesis and Patterning
Sex Determination and Differentiation
The Development of the Excretory System
Pituitary Gland Development
Sensory Organs: Eye
Development of the Mouse Inner Ear
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