Signed Edition Sweepstakes
 
 

Recently Viewed clear list


Original Essays | September 17, 2014

Merritt Tierce: IMG Has My Husband Read It?



My first novel, Love Me Back, was published on September 16. Writing the book took seven years, and along the way three chapters were published in... Continue »

spacer
Qualifying orders ship free.
$53.50
New Trade Paper
Ships in 1 to 3 days
Add to Wishlist
available for shipping or prepaid pickup only
Available for In-store Pickup
in 7 to 12 days
Qty Store Section
1 Remote Warehouse Chemistry- Physical Chemistry

This title in other editions

Acids and Bases: Solvent Effects on Acid-Base Strength

by

Acids and Bases: Solvent Effects on Acid-Base Strength Cover

 

Synopses & Reviews

Publisher Comments:

Acids and bases are ubiquitous in chemistry. Our understanding of them, however, is dominated by their behaviour in water. Transfer to non-aqueous solvents leads to profound changes in acid-base strengths and to the rates and equilibria of many processes: for example, synthetic reactions involving acids, bases and nucleophiles; isolation of pharmaceutical actives through salt formation; formation of zwitter- ions in amino acids; and chromatographic separation of substrates. This book seeks to enhance our understanding of acids and bases by reviewing and analysing their behaviour in non-aqueous solvents. The behaviour is related where possible to that in water, but correlations and contrasts between solvents are also presented.

Fundamental background material is provided in the initial chapters: quantitative aspects of acid-base equilibria, including definitions and relationships between solution pH and species distribution; the influence of molecular structure on acid strengths; and acidity in aqueous solution. Solvent properties are reviewed, along with the magnitude of the interaction energies of solvent molecules with (especially) ions; the ability of solvents to participate in hydrogen bonding and to accept or donate electron pairs is seen to be crucial. Experimental methods for determining dissociation constants are described in detail.

In the remaining chapters, dissociation constants of a wide range of acids in three distinct classes of solvents are discussed: protic solvents, such as alcohols, which are strong hydrogen-bond donors; basic, polar aprotic solvents, such as dimethylformamide; and low-basicity and low polarity solvents, such as acetonitrile and tetrahydrofuran. Dissociation constants of individual acids vary over more than 20 orders of magnitude among the solvents, and there is a strong differentiation between the response of neutral and charged acids to solvent change. Ion-pairing and hydrogen-bonding equilibria, such as between phenol and phenoxide ions, play an increasingly important role as the solvent polarity decreases, and their influence on acid-base equilibria and salt formation is described.

About the Author

Dr Brian G. Cox was educated at the University of Melbourne, followed by academic research or teaching posts at the Australian National University, the University of Stirling, Cornell University, and the Max-Planck Institut fur biophys. Chemie, Gottingen. He subsequently held industrial positions of Corporate Research Associate with ICI and Syngenta, and Associate Principal Scientist and Consultant with AstraZeneca. In addition, he has held Visiting Professorships at the Universities of Surrey, St Andrews, Bologna, and Chieti, and University College, Dublin, and most recently acted as Senior Advisor in Chemistry at the Institute of Chemical and Engineering Science in Singapore.

Table of Contents

1. Introduction

2. Acid-base equilibria: quantitative treatment

3. Solvation and acid-base strength

4. Solvation and acid-base strength

5. Protic solvents

6. High-basicity, aprotic solvents

7. Low-basicity and low-polarity aprotic solvents

8. Acid-base equilibria and salt formation

9. Appendices: Dissociation constants in methanol and aprotic solvents

Index

Product Details

ISBN:
9780199670529
Author:
Cox, Brian G.
Publisher:
Oxford University Press, USA
Subject:
Chemistry - Physical & Theoretical
Subject:
Chemistry | Physical Chemistry
Publication Date:
20130331
Binding:
TRADE PAPER
Language:
English
Illustrations:
54 b/w line illustrations
Pages:
160
Dimensions:
7.4 x 9.6 x 0.4 in 0.8 lb

Related Subjects


Science and Mathematics » Chemistry » Inorganic
Science and Mathematics » Chemistry » Physical Chemistry

Acids and Bases: Solvent Effects on Acid-Base Strength New Trade Paper
0 stars - 0 reviews
$53.50 In Stock
Product details 160 pages Oxford University Press, USA - English 9780199670529 Reviews:
spacer
spacer
  • back to top
Follow us on...




Powell's City of Books is an independent bookstore in Portland, Oregon, that fills a whole city block with more than a million new, used, and out of print books. Shop those shelves — plus literally millions more books, DVDs, and gifts — here at Powells.com.