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DNA Microarrays and Gene Expression: From Experiments to Data Analysis and Modelingby Pierre Baldi
Synopses & Reviews
Massive data acquisition technologies--such as genome sequencing, high-throughput drug screening, and DNA arrays-- are in the process of revolutionizing biology and medicine. Using the mRNA of a given cell, at a given time, under a given set of conditions, DNA microarrays can provide a snapshot of the level of expression of all the genes in the cell. Such snapshots can be used to study fundamental biological phenomena such as development or evolution, to determine the function of new genes, to infer the role individual genes or groups of genes may play in diseases, and to monitor the effect of drugs and other compounds on gene expression.
Book News Annotation:
Baldi (genomics, bioinformatics) and Hatfield (microbiology, molecular genetics: both authors teach at the U. of California, Irvine), drawing on the joint technology from their fields, have written a detailed introduction to DNA microarray technology with the researcher in mind. The book begins with an overview of genomics then turns to DNA array technologies with chapters on methods, technology, instrumentation, design issues, current problematic aspects of gene expression profiling experiments, different levels of statistical analysis, an overview of applications, and an introduction to systems biology.
Annotation c. Book News, Inc., Portland, OR (booknews.com)
This volume offers a concise, inter-disciplinary introduction to DNA micro-array technology, which is revolutionising biology and medicine.
DNA microarrays are in the process of revolutionizing biology and medicine. They can provide a snapshot of the level of expression of all the genes in the cell. Such snapshots can be used to study development and evolution, to determine the function of new genes, to infer the role genes may play in diseases, and to monitor the effect of drugs and other compounds on gene expression. This inter-disciplinary introduction to DNA arrays will be essential reading for all researchers wanting to take advantage of this powerful new technology.
Concise, inter-disciplinary introduction to DNA microarray technology, which is revolutionising biology and medicine.
About the Author
Pierre Baldi is Professor and Director of the Institute for Genomics and Bioinformatics in the Department of Information and Computer Science and in the Department of Biological Chemistry in the College of Medicine at the University of California, Irvine.Wes Hatfield is a Professor in the Department of Microbiology and Molecular Genetics in the College of Medicine and the Department of Chemical Engineering and Material Sciences in the School of Engineering at the University of California, Irvine.
Table of Contents
Preface; 1. A brief history of genomics; 2. DNA array formats; 3. DNA array readout methods; 4. Gene expression profiling experiments: problems, pitfalls and solutions; 5. Statistical analysis of array data: inferring changes; 6. Statistical analysis of array data: dimensionality reduction, clustering, and regulatory regions; 7. Survey of current DNA array applications; 8. Systems biology: overview of regulatory, metabolic and signaling networks.
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