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Other titles in the Woodhead Publishing Series in Biomaterials series:
Standardisation in Cell and Tissue Engineering: Methods and Protocols (Woodhead Publishing Series in Biomaterials)by Vehid Salih.
Synopses & Reviews
The increased use of biodegradable synthetic or natural scaffolds combined with cells and/or biological molecules to create functional replacement tissue in a damaged tissue site, has led to the need for the development of "best practice" methods in the area of tissue engineering to help ensure the creation of safe, high quality productions. Standardisation in cell and tissue engineering introduces the developments and current practice in the field of cell and tissue engineering to a wide audience and aims to provide awareness of the importance of standardization in this area, while also suggesting directions for future research.
Part one provides an overview of methods for cell and tissue engineering and includes chapters on the fundamentals of cell and matrix biology for tissue engineering, three-dimensional collagen biomatrix development, tissue culture methods for hard and soft tissue engineering, and vascularization of tissue engineered constructs. Part two begins with a chapter reviewing current international standards in cell and tissue engineering, before moving on to highlight issues of quality control, standardized chemical analysis and testing of biomaterials and principles of good laboratory practice (GLP) for in vitro cell culture applications.
The promises and objectives of tissue engineering proposed over three decades ago have not delivered the products and synthetic therapies for most of the requirements of diseased or traumatized tissues. This may be due to the lack of standardization during the induction, development, and maintenance of differentiation within cells and tissue matrices under in vitro conditions.
The chapter authors comprehensively outline the fundamentals of standard protocols in cell maintenance in culture, preservation and characterization, and the technology and issues surrounding the synthesis, evaluation, and characterization of cel-based tissue engineered products. Contributors in concluding chapters address both good laboratory practice (GLP) and good manufacturing practice (GMP)for cell-culture processes.
The promises and objectives of tissue engineering proposed over three decades ago have not delivered the products and synthetic therapies for most of the requirements of diseased or traumatized tissues. This may be due to the lack of standardization during the induction, development, and maintenance of differentiation within cells and tissue matrices under in vitro conditions. The editor and contributors bring together standard methods and protocols for these therapies with an objective to increase the speed and development of new products to market. Chapters discuss methods for standardizing cell and tissue engineering applications and the protocols surrounding cell and tissue engineering.
About the Author
Vehid Salih is Senior Lecturer in Biomaterials and Tissue Engineering at University College London, UK. His research activities include: cell and biomaterial interactions, characterization of tissue engineered constructs and the development of standardized culture protocols.
Table of Contents
Part 1 Methods in standardisation of cell and tissue engineering: Fundamentals of cell and matrix biology; Biomatrix development; New concepts and therapies in cell engineering; Synthetic materials development; 2D/3D tissue culture methods for soft tissues; 2D/3D tissue culture methods for hard tissues; Standards in physical therapies
Part 2 Protocols in standardisation of cell and tissue engineering: Quality control; Sterilisation procedures; Standardising methods and regulatory Issues; Standardization of protocols for global manufacture
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