The Fictioning Horror Sale
 
 

Recently Viewed clear list


Powell's Q&A | September 3, 2014

Emily St. John Mandel: IMG Powell’s Q&A: Emily St. John Mandel



Describe your latest book. My new novel is called Station Eleven. It's about a traveling Shakespearean theatre company in a post-apocalyptic North... Continue »
  1. $17.47 Sale Hardcover add to wish list

    Station Eleven

    Emily St. John Mandel 9780385353304

spacer

On Order

$84.50
New Trade Paper
Currently out of stock.
Add to Wishlist
available for shipping or prepaid pickup only
Qty Store Section
- Local Warehouse Biology- General

The Subversion of Treg-Mediated Transplantation Tolerance by Toll-Like Receptor Signals.

by

The Subversion of Treg-Mediated Transplantation Tolerance by Toll-Like Receptor Signals. Cover

 

Synopses & Reviews

Publisher Comments:

Immune activation via Toll-like receptors (TLRs) has recently been identified as an important barrier to the induction of donor-specific transplantation tolerance, but the exact mechanisms underlying this barrier remain unclear. To better understand how TLR ligation interferes with the induction of donor-specific tolerance, we used complementary murine models of skin and cardiac transplantation in which prolonged allograft acceptance is either spontaneous or pharmacologically induced with anti-CD154 mAb and rapamycin. In each model, we found that prolonged allograft survival requires the presence of natural CD4+Foxp3+ regulatory T cells, and that TLR ligation prevents graft acceptance both by interfering with natural Treg function and by promoting the differentiation of Th1 effector T cells in vivo. We further demonstrate that TLR ligands mediate these effects in the absence of IL-6, and that Th17 cells do not participate in the abrogation of tolerance by TLR ligands. Finally, in light of our observation that rapamycin induces CD4+Foxp3+ adaptive Treg conversion from alloreactive Foxp3-effector T cells, we investigated the role of these cells in the tolerance process and conclude that natural Tregs are the dominant Foxp3+ regulatory T cell subset that establishes immunoregulation in animals treated with costimulatory blockade and rapamycin. Altogether, these data suggest that TLR signals do not prevent prolonged graft acceptance by preventing alloantigen-specific adaptive Treg differentiation. Instead, graft destruction results from the ability of TLR ligands to promote Th1 differentiation and interfere with immunoregulation established by alloreactive natural CD4+Foxp3+ Tregs.

Product Details

ISBN:
9781243590220
Author:
Porrett, Paige Marie
Publisher:
Proquest, Umi Dissertation Publishing
Subject:
Biology-General
Publication Date:
20110931
Binding:
TRADE PAPER
Language:
English

Related Subjects

Science and Mathematics » Biology » General

The Subversion of Treg-Mediated Transplantation Tolerance by Toll-Like Receptor Signals. New Trade Paper
0 stars - 0 reviews
$84.50 Backorder
Product details pages Proquest, Umi Dissertation Publishing - English 9781243590220 Reviews:
spacer
spacer
  • back to top
Follow us on...




Powell's City of Books is an independent bookstore in Portland, Oregon, that fills a whole city block with more than a million new, used, and out of print books. Shop those shelves — plus literally millions more books, DVDs, and gifts — here at Powells.com.