Warriors B2G1 Free
 
 

Special Offers see all

Enter to WIN a $100 Credit

Subscribe to PowellsBooks.news
for a chance to win.
Privacy Policy

Visit our stores


    Recently Viewed clear list


    Q&A | May 12, 2015

    Aleksandar Hemon: IMG Powell’s Q&A: Aleksandar Hemon



    Describe your latest book. The Making of Zombie Wars is a roller-coaster ride of violence and sex. The main character, Joshua Levin, is a modestly... Continue »
    1. $18.20 Sale Hardcover add to wish list

      The Making of Zombie Wars

      Aleksandar Hemon 9780374203412

    spacer

This item may be
out of stock.

Click on the button below to search for this title in other formats.


Check for Availability
Add to Wishlist

The Subversion of Treg-Mediated Transplantation Tolerance by Toll-Like Receptor Signals.

The Subversion of Treg-Mediated Transplantation Tolerance by Toll-Like Receptor Signals. Cover

 

Synopses & Reviews

Publisher Comments:

Immune activation via Toll-like receptors (TLRs) has recently been identified as an important barrier to the induction of donor-specific transplantation tolerance, but the exact mechanisms underlying this barrier remain unclear. To better understand how TLR ligation interferes with the induction of donor-specific tolerance, we used complementary murine models of skin and cardiac transplantation in which prolonged allograft acceptance is either spontaneous or pharmacologically induced with anti-CD154 mAb and rapamycin. In each model, we found that prolonged allograft survival requires the presence of natural CD4+Foxp3+ regulatory T cells, and that TLR ligation prevents graft acceptance both by interfering with natural Treg function and by promoting the differentiation of Th1 effector T cells in vivo. We further demonstrate that TLR ligands mediate these effects in the absence of IL-6, and that Th17 cells do not participate in the abrogation of tolerance by TLR ligands. Finally, in light of our observation that rapamycin induces CD4+Foxp3+ adaptive Treg conversion from alloreactive Foxp3-effector T cells, we investigated the role of these cells in the tolerance process and conclude that natural Tregs are the dominant Foxp3+ regulatory T cell subset that establishes immunoregulation in animals treated with costimulatory blockade and rapamycin. Altogether, these data suggest that TLR signals do not prevent prolonged graft acceptance by preventing alloantigen-specific adaptive Treg differentiation. Instead, graft destruction results from the ability of TLR ligands to promote Th1 differentiation and interfere with immunoregulation established by alloreactive natural CD4+Foxp3+ Tregs.

Product Details

ISBN:
9781243590220
Publisher:
Proquest, Umi Dissertation Publishing
Subject:
Biology-General
Author:
Porrett, Paige Marie
Publication Date:
20110931
Binding:
TRADE PAPER
Language:
English

Related Subjects

Science and Mathematics » Biology » General

The Subversion of Treg-Mediated Transplantation Tolerance by Toll-Like Receptor Signals.
0 stars - 0 reviews
$ In Stock
Product details pages Proquest, Umi Dissertation Publishing - English 9781243590220 Reviews:
spacer
spacer
  • back to top

FOLLOW US ON...

     
Powell's City of Books is an independent bookstore in Portland, Oregon, that fills a whole city block with more than a million new, used, and out of print books. Shop those shelves — plus literally millions more books, DVDs, and gifts — here at Powells.com.