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Nuclear Organization and Function

Nuclear Organization and Function Cover


Synopses & Reviews

Publisher Comments:

This volume is based on presentations by the world-renowned investigators who gathered at the 75th annual Cold Spring Harbor Symposium on Quantitative Biology to discuss the organization and function of the cell nucleus. It reviews the latest advances in research into nuclear structure, the organization of the genome within the nucleus, and spatiotemporal coordination of nuclear processes. The topics examined include nuclear domains, chromatin organization, transcription and RNA processing, DNA replication, nuclear reprogramming, and epigenetics. Cancer, premature aging syndromes, and other diseases that may be associated with altered nuclear organization are also covered.

Book News Annotation:

The 62 papers in this collection originally were presented during the Cold Spring Harbor Symposium on Quantitative Biology held in June 2010 at Cold Spring Harbor Laboratory in New York. Topics include: chromatin modifications and gene expression, transcription and beyond, DNA replication and genome integrity, reprogramming and differentiation, nuclear bodies and RNA biology, chromosome structure and mitosis, and nuclear periphery. Annotation ©2011 Book News, Inc., Portland, OR (


The 75th CSH Symposium volume reviews the latest advances in research into nuclear structure, the organization of the genome within the nucleus, and spatiotemporal coordination of nuclear processes.

Table of Contents

Chromatin Modifications and Gene Expression

Drosophila Heat Shock System as a General Model to Investigate Transcriptional Regulation

M.J. Guertin, S.J. Petesch, K.L. Zobek, I.M. Min, and J.T. Lis

Chromatin in the Nuclear Landscape

D.B. Beck, R. Bonasio, S. Kaneko, G. Li, G. Li, R. Margueron, H. Oda, K. Sarma, R.J. Sims III, J. Son, P. Trojer, and D. Reinberg

Cell Signaling and Transcriptional Regulation via Histone Phosphorylation

S.L. Berger

HIRA and Daxx Constitute Two Independent Histone H3.3-Containing Predeposition Complexes

S.J. Elsaesser and C.D. Allis

The INO80 Family of Chromatin-Remodeling Enzymes: Regulators of Histone Variant Dynamics

S. Watanabe and C.L. Peterson

Role of K3K27 Demethylases Jmjd3 and UTX in Transcriptional Regulation

M.R. Hübner and D.L. Spector

Epigenetic Inheritance of Centromeres

S. Henikoff and T. Furuyama

Functional Dissection of Polycomb Repressive Complex 1 Reveals the Importance of a Charged Domain

D.J. Grau, J.M. Antao, and R.E. Kingston

Histone Acetylation and the Maintenance of Chromatin Compaction by Polycomb Repressive Complexes

R. Eskeland, E. Freyer, M. Leeb, A. Wutz, and W.A. Bickmore

Chromatin Boundaries, Insulators, and Long-Range Interactions in the Nucleus

K.E. Giles, H. Gowher, R. Ghirlando, C. Jin, and G. Felsenfeld

Transcription and Beyond

Nuclear Origins of Cell-to-Cell Variability

Z. Waks and P.A. Silver

The Role of Cotranscriptional Histone Methylations

S. Buratowski and T. Kim

Chromatin and Alternative Splicing

M. Alló, I.E. Schor, M.J. Muñoz, M. de la Mata,E. Agirre, J. Valcárcel, E. Eyras, and A.R. Kornblihtt

Nuclear Physics: Quantitative Single-Cell Approaches to Nuclear Organization and Gene Expression

T. Lionnet, B. Wu, D. Grünwald, R.H. Singer, and D.R. Larson

CBP80-Promoted mRNP Rearrangements during the Pioneer Round of Translation, Nonsense-Mediated mRNA Decay, and Thereafter

L.E. Maquat, J. Hwang, H. Sato, and Y. Tang

DNA Replication and Genome Integrity

The Many Faces of Redundancy in DNA Replication Control

J.F.X. Diffley

Space and Time in the Nucleus: Developmental Control of Replication Timing and Chromosome Architecture

D.M. Gilbert, S.-I. Takebayashi, T. Ryba, J. Lu, B.D. Pope, K.A. Wilson, and I. Hiratani

Heterochromatin at Mouse Pericentromeres: A Model for De Novo Heterochromatin Formation and Duplication during Replication

C. Maison, J.-P. Quivy, A.V. Probst, and G. Almouzni

How Shelterin Solves the Telomere End-Protection Problem

T. de Lange

The Smc5/6 Complex: More than Repair?

A. Kegel and C. Sjögren

Reprogramming and Differentiation

Efficiencies and Mechanisms of Nuclear Reprogramming

V. Pasque, K. Miyamoto, and J.B. Gurdon

Gene Targeting in Human Pluripotent Cells

D. Hockemeyer and R. Jaenisch

Epigenetic Reprogramming of Mouse Germ Cells toward Totipotency

M.A. Surani and P. Hajkova

Nuclear Mobility and Mitotic Chromosome Binding: Similarities between Pioneer Transcription Factor FoxA and Linker Histone H1

K.S. Zaret, J.M. Caravaca, A. Tulin, and T. Sekiya

Connecting Transcriptional Control to Chromosome Structure and Human Disease

J.J. Newman and R.A. Young

Transcription Factors for the Modulation of Pluripotency and Reprogramming

J.-C.D. Heng, Y.L. Orlov, and H.-H. Ng

Changes in Chromatin Fiber Density as a Marker for Pluripotency

E. Fussner, K. Ahmed, H. Dehghani, M. Strauss, and D.P. Bazett-Jones

Cancer Epigenetics: From Disruption of Differentiation Programs to the Emergence of Cancer Stem Cells

P. Scaffidi and T. Misteli

Heterochromatin Formation and Gene Silencing

Assembly and Functions of Heterochromatin in the Fission Yeast Genome

O. Aygün and S.I.S. Grewal

Germline Reprogramming of Heterochromatin in Plants

K.M. Creasey and R.A. Martienssen

On the Connection between RNAi and Heterochromatin at Centromeres

E. Lejeune, E.H. Bayne, and R.C. Allshire

Evolutionary History of Plant Multisubunit RNA Polymerases IV and V: Subunit Origins via Genome-Wide and Segmental Gene Duplications, Retrotransposition, and Lineage-Specific Subfunctionalization

S.L. Tucker, J. Reece, T.R. Ream, and C.S. Pikaard

Transcriptional Interference and Gene Orientation in Yeast: Noncoding RNA Connections

M. Gullerova and N.J. Proudfoot

Nuclear Bodies and RNA Biology

Cajal Bodies and Histone Locus Bodies in Drosophila and Xenopus

Z.F. Nizami, S. Deryusheva, and J.G. Gall

Down-Regulation of a Host microRNA by a Viral Noncoding RNA

D. Cazalla and J.A. Steitz

Long Noncoding RNAs as Enhancers of Gene Expression

U.A. &Ostrike;rom, T. Derrien, R. Guigo, and R. Shiekhattar

Chromatin Structure and Nuclear Organization Dynamics during X-Chromosome Inactivation

E.P. Nora and E. Heard

XIST RNA and Architecture of the Inactive X Chromosome: Implications for the Repeat Genome

L.L. Hall and J.B. Lawrence

Noncoding Transcripts in Sense and Antisense Orientation Regulate the Epigenetic State of Ribosomal RNA Genes

H. Bierhoff, K. Schmitz, F. Maass, J. Ye, and I. Grummt

Genetic Analysis of Nuclear Bodies: From Nondeterministic Chaos to Deterministic Order

T.K. Rajendra, K. Praveen, and A.G. Matera

Chromosome Structure and Mitosis

Splitting the Nucleus: What's Wrong with the Tripartite Ring Model?

K. Nasmyth and R.A. Oliveira

Physical Linkages between Sister Chromatids and Their Removal during Yeast Chromosome Segregation

J. Baxter and L. Aragón

Molecular Structures and Interactions in the Yeast Kinetochore

U.-S. Cho, K.D. Corbett, J. Al-Bassam, J.J Bellizzi III, P. De Wulf, C.W. Espelin, J.J. Miranda, K. Simons, R.R. Wei, P.K. Sorger, and S.C. Harrison

Centromere Identity, Function, and Epigenetic Propagation across Cell Divisions

B.E. Black, L.E.T. Jansen, D.R. Foltz, and D.W. Cleveland

Temporal and Spatial Regulation of Targeting Aurora B to the Inner Centromere

Y. Watanabe

The Life Cycle of Centrioles

E. Hatch and T. Stearns

Proteomics of Isolated Mitotic Chromosomes Identifies the Kinetochore Protein Ska3/Rama1

S. Ohta, J.-C. Bukowski-Wills, L. Wood, F. de Lima Alves, Z. Chen, J. Rappsilber, and W.C. Earnshaw

New Insight into the Mitotic Chromosome Structure: Irregular Folding of Nucleosome Fibers Without 30-nm Chromatin Structure

K. Maeshima, S. Hihara, and H. Takata

Thoughts on Aneuploidy

E.M. Torres, B.R. Williams, Y.-C. Tang, and A. Amon

Chromatin Structure and Organization

Insights into Interphase Large-Scale Chromatin Structure from Analysis of Engineered Chromosome Regions

A.S. Belmont, Y. Hu, P.B. Sinclair, W. Wu, Q. Bian, and I. Kireev

Chromatin Folding: From Linear Chromosomes to the 4D Nucleus

T. Cheutin, F. Bantignies, B. Leblanc, and G. Cavalli

Functional Nuclear Organization of Transcription and DNA Replication: A Topographical Marriage between Chromatin Domains and the Interchromatin Compartment

Y. Markaki, M. Gunkel, L. Schermelleh, S. Beichmanis, J. Neumann, M. Heidemann, H. Leonhardt, D. Eick, C. Cremer, and T. Cremer

Window into the Complexities of Chromosome Interactomes

A. Göndör, A. Fernandez Woodbridge, C. Shi, E. Aurell, M. Imreh, and R. Ohlsson

Transcription Factories and Nuclear Organization of the Genome

C.H. Eskiw, N.F. Cope, I. Clay, S. Schoenfelder, T. Nagano, and P. Fraser

Role of Nuclear Architecture in Epigenetic Alterations in Cancer

H.P. Easwaran and S.B. Baylin

Nuclear Periphery

Role of the Nuclear Lamina in Genome Organization and Gene Expression

D. Peric-Hupkes and B. van Steensel

Nuclear Lamins in Cell Regulation and Disease

T. Shimi, V. Butin-Israeli, S.A. Adam, and R.D. Goldman

Lamina-Independent Lamins in the Nuclear Interior Serve Important Functions

T. Dechat, K. Gesson, and R. Foisner

Three-Dimensional Organization of Chromatids by Nuclear EnvelopeAssociated Structures

G. Blobel

Repetitive Transgenes in C. elegans Accumulate Heterochromatic Marks and Are Sequestered at the Nuclear Envelope in a Copy Number- and Lamin-Dependent Manner

B.D. Towbin, P. Meister, B.L. Pike, and S.M. Gasser

The Mechanism of Nucleocytoplasmic Transport through the Nuclear Pore Complex

J. Tetenbaum-Novatt and M.P. Rout

Nuclear Pore Complexes: Guardians of the Nuclear Genome

M. Capelson, C. Doucet, and M.W. Hetzer

Structure and Function of the Perinucleolar Compartment in Cancer Cells

A. Slusarczyk, R. Kamath, C. Wang, D. Anchel, C. Pollock, M.A. Lewandowska, T. Fitzpatrick, D.P. Bazett-Jones, and S. Huang

Summary: The Nucleus A Close-Knit Community of Dynamic Structures

S. Henikoff

Author Index

Subject Index

Product Details

Cold Spring Harbor Laboratory Press
Biology-Cytology and Cell Biology
Stewart, David
Grodzicker, Terri
Spector, David L.
Series Volume:
Cold Spring Harbor S
Publication Date:
7.8 x 10.6 x 1.2 in 3.6 lb

Related Subjects

Science and Mathematics » Biology » Cytology and Cell Biology
Science and Mathematics » Biology » Genetics
Science and Mathematics » Biology » Molecular

Nuclear Organization and Function
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Product details pages Cold Spring Harbor Laboratory Press - English 9781936113088 Reviews:
"Synopsis" by , The 75th CSH Symposium volume reviews the latest advances in research into nuclear structure, the organization of the genome within the nucleus, and spatiotemporal coordination of nuclear processes.
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