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This title in other editions

Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics

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Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics Cover

 

Synopses & Reviews

Publisher Comments:

One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. An Introduction to ProteinDNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about proteinDNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create unified view of the field and a fuller understanding of proteinDNA interactions.

Table of Contents

Preface

1 Importance of Protein-DNA Interactions

STRUCTURE

2 The Structure of DNA

3 Protein Structure and DNA Recognition

4 Sequence-Specific Interactions in Protein-DNA Complexes

THERMODYNAMICS

5 Binding Affinity, Cooperativity, and Specificity

6 Energetics and Kinetics of Binding

BIOINFORMATICS

7 Bioinformatics of DNA-Binding Sites

8 Bioinformatics of Transcription Factors and Recognition Models

9 Transcriptional Genomics

Index

Product Details

ISBN:
9781936113507
Author:
Stormo, Gary D.
Publisher:
Cold Spring Harbor Laboratory Press
Author:
Stormo, Gary
Subject:
Biochemistry
Subject:
Chemistry-Biochemistry
Publication Date:
20130231
Binding:
TRADE PAPER
Language:
English
Illustrations:
78 4C, 5 BandW
Pages:
208
Dimensions:
6.6 x 9 x 0.4 in 0.85 lb

Related Subjects


Science and Mathematics » Biology » Molecular
Science and Mathematics » Chemistry » Biochemistry

Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics New Trade Paper
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Product details 208 pages Cold Spring Harbor Laboratory Press - English 9781936113507 Reviews:
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