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Medicinal Chemistry (3RD 05 Edition)

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Synopses & Reviews

Please note that used books may not include additional media (study guides, CDs, DVDs, solutions manuals, etc.) as described in the publisher comments.

Publisher Comments:

Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and biochemical principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource.

Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and exogenous pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered.

There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.

Synopsis:

Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource.

Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered.

There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.

Table of Contents

PART I: Physiochemical Principles of Drug Action


1. Role and Structure of Water


2. Solubility


3. Partition Coefficients


4. Surface Activity and Drug Effects


5. Stereochemical Aspects of Drug Action


6. Electronic Structure and its Effects on Drug Activity


7. Chemical Bonding and Biological Activity


8. Quantum Chemical Aspects of Drug Action


9. Quantitative Structure-Activity Relationships


PART II: Receptor-Effector Theories


1. The Receptor Concept and its History


2. The Nature of Receptors and the Criteria of Receptor Identity


3. Definition of Pharmacological Binding Terms


4. Classical Theories of Concentration-Response Relationships


5. Molecular Concepts of Receptor Function


PART III: Methods of Receptor Characterization


1. Methodological Principles


2. Indirect Methods of Receptor Characterization


3. Direct Methods of Receptor Characterization


4. Data Treatment


PART IV: Drugs Acting on Neurotransmitters and Their Receptors


1. Outline of Neuroanatomy and Neurophysiology


2. Acetylcholine and the Cholinergic Receptors


3. Norepinephrine and the Adrenergic Receptors


4. Dopamine and the Dopaminergic Receptors


5. Serotonin and the Serotonergic Drug Effects


6. Histamine and the Histamine Receptors


7. Purinergic Neuromodulation and the Adenosine Receptors


8. Aminoacid Neurotransmitters and the Drug Effects They Mediate


PART V: Drugs Acting on Hormones, Neurohormones, and Their Receptors


1. Steroid Hormones and Their Receptors


2. Peptide and Protein Hormones and Neurohormones


3. Enkephalins, Endorphins, and Opiate Analgesics


4. Prostaglandins and Thromboxanes


5. Atrial Natriuretic Factors


PART VI: Non-Messenger Targets for Drug Action


1. Excitable Membranes


2. Cell-Wall Synthesis Inhibitors


3. Enzymes as Drug Targets


4. Vitamins


5. Nucleic Acids as Targets for Drug Action


PART VII: Drug Distribution and Metabolism


1. Drug Distribution


2. Drug Metabolism


PART VIII: Principles of Drug Design


1. Analogue Synthesis Versus Rational Design


2. Discovery of "Lead" Compounds


3. Pharmacophore Identification


4. Pro-Drugs and "Soft" Drugs


Product Details

ISBN:
9780195104561
Author:
Nogrady
Publisher:
Oxford University Press, USA
Author:
Weaver, Donald F.
Author:
null, Donald F.
Author:
Nogrady, Thomas
Author:
Nogrady, Th
Author:
null, Thomas
Subject:
Psychology
Subject:
Toxicology
Subject:
Pharmacology
Subject:
Pharmaceutical chemistry
Subject:
Chemistry, Pharmaceutical.
Subject:
Medicine | Psychiatry
Subject:
Medicine | Pharmacology
Subject:
Medicine | Psychiatry and Psychology
Subject:
Drug Design.
Subject:
Medicine | Pharmacology & Toxicology
Subject:
Health and Medicine-Pharmacology
Edition Number:
3
Edition Description:
Third
Publication Date:
20050831
Binding:
TRADE PAPER
Grade Level:
Professional and scholarly
Language:
English
Illustrations:
319 line illus. incl. chemical structure
Pages:
672
Dimensions:
6.4 x 9.1 x 1.2 in 2.169 lb

Related Subjects

Health and Self-Help » Health and Medicine » Medical Specialties
Health and Self-Help » Health and Medicine » Pharmacology
Humanities » Philosophy » General
Metaphysics » Numerology
Science and Mathematics » Chemistry » Biochemistry
Science and Mathematics » Environmental Studies » General

Medicinal Chemistry (3RD 05 Edition) Used Trade Paper
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$48.00 In Stock
Product details 672 pages Oxford University Press - English 9780195104561 Reviews:
"Synopsis" by , Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource.

Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered.

There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.

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