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Biophysical Chemistry

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Biophysical Chemistry Cover

 

Synopses & Reviews

Publisher Comments:

"Biophysical Chemistry is an outstanding book that delivers both fundamental and complex biophysical principles, along with an excellent overview of the current biophysical research areas, in a manner that makes it accessible for mathematically and non-mathematically inclined readers." (Journal of Chemical Biology, February 2009)

 

This text presents physical chemistry through the use of biological and biochemical topics, examples and applications to biochemistry. It lays out the necessary calculus in a step by step fashion for students who are less mathematically inclined, leading them through fundamental concepts, such as a quantum mechanical description of the hydrogen atom rather than simply stating outcomes. Techniques are presented with an emphasis on learning by analyzing real data.

  • Presents physical chemistry through the use of biological and biochemical topics, examples and applications to biochemistry

  • Lays out the necessary calculus in a step by step fashion for students who are less mathematically inclined

  • Presents techniques with an emphasis on learning by analyzing real data

  • Features qualitative and quantitative problems at the end of each chapter

  • All art available for download online and on CD-ROM

Book News Annotation:

This text for undergraduate biochemistry students presents physical chemistry through the use of biological and biochemical topics, examples, and applications to biochemistry. It offers a rigorous treatment of the material without presuming a strong prior knowledge of math theory. Necessary calculus models are laid out in a step-by-step fashion for students less confident in their math abilities. Students are guided through an in-depth understanding of fundamental concepts, and techniques are presented with an emphasis on learning through analysis of real data. Chapters are presented in sections on thermodynamics and kinetics, quantum mechanics and spectroscopy, and understanding biological systems using physical chemistry. Chapters in the third section are independent of each other and can be presented in any combination. Cases are drawn from current research areas in biochemistry using an integrated approach to problem solving. Every chapter features math and derivation boxes, and examples of both numerical and concept-based problems. The art program offers color explanatory diagrams on every page. The artwork is also available for download from a web site. The text can be used with students in biochemistry, physics, biology, and engineering. Allen teaches at Arizona State University. Annotation ©2008 Book News, Inc., Portland, OR (booknews.com)

Synopsis:

James Allen is a professor at Arizona State University. He has won numerous honors including several study sections with the National Institutes for Health and was selected for Who’s Who Among America’s Teachers.

Synopsis:

Biophysical Chemistry presents physical chemistry through the use of biological and biochemical topics, examples, and applications to biochemistry. It presents a rigorous, up-to-date treatment of the material without presuming a strong prior knowledge of math theory. Necessary calculus models are laid out in a step-by-step fashion for students less confident in their math abilities. The format of the text allows teachers ample flexibility in deciding which derivations to present in class. Students are guided through an in-depth understanding of fundamental concepts – such as a quantum-mechanical description of the hydrogen atom – and techniques are presented with an emphasis on learning through analysis of real data. Cases are drawn from timely research areas in biochemistry using an integrated approach to problem solving. Every chapter features important recent advances in biochemistry, an examination of current research problems, math and derivation boxes to guide students, and examples of both numerical and concept-based problems. Artwork from the book is available for download by instructors at www.blackwellpublishing.com/allenbiophysical

About the Author

"Biophysical Chemistry is an outstanding book that delivers both fundamental and complex biophysical principles, along with an excellent overview of the current biophysical research areas, in a manner that makes it accessible for mathematically and non-mathematically inclined readers." (Journal of Chemical Biology, February 2009)

"This is strongly recommended as a textbook for advanced undergraduate and graduate students with backgrounds in the physical and biological sciences. It will also prove extremely useful to university and high school educators, medical doctors, and researchers who want to go beyond a surface treatment of biological phenomenology to its roots in physics and chemistry." (Doody's, February, 2009)

Table of Contents

Preface.

0. Basic thermodynamic and biochemical concepts.

0.1 Fundamental thermodynamic concepts.

States of matter.

Pressure.

Temperature.

Volume, mass, and number.

0.2 Properties of gases.

The ideal gas laws.

Gas Mixtures.

0.3 Kinetic energy of gases.

0.4 Real Gases.

Liquifying gases for low temperature spectroscopy.

0.5 Molecular Basis for Life.

Cell Membranes.

Amino acids.

Classification of amino acids by their side chains.

DNA and RNA.

1. First law of thermodynamics.

Systems.

State Functions.

First law of thermodynamics.

1.1 Research Direction: Drug design I.

Work.

Specific heat.

Internal energy for an ideal gas.

Enthalpy.

Dependence of specific heat on enthalpy.

Derivative box: State Functions described using partial derivatives.

Enthalpy changes of biochemical reactions.

1.2 Research Direction: Global climate change.

2. Second law of thermodynamics.

Entropy.

Entropy changes for reversible and irreversible processes.

The second law of thermodynamics.

Interpretation of entropy.

Third law of thermodynamics.

Gibbs energy.

Relationship between the Gibbs free energy and the equilibrium constant.

2.1 Research Direction: Drug design II.

Gibbs free energy for an ideal gas.

Using the Gibbs free energy.

Carnot cycle and hybrid cars.

Derivative box: Entropy as a state function.

2.2 Research Direction: Nitrogen fixation.

3. Phase diagrams, mixtures and chemical potential.

Substances may exist in different phases.

Phase diagrams and transitions.

Chemical potential.

Properties of lipids described using the chemical potential.

3.1 Research Direction: lipid rafts.

Determination of micelle formation using surface tension.

Mixtures.

Raoult’s law.

Osmosis.

3.2 Research Direction: Protein crystallization.

4. Equilibria and reactions involving protons.

Gibbs free energy minimum.

Derivative box:Relationship between the Gibbs energy and equilibrium constant.

Response of the equilibrium constant to condition changes.

Acid-base equilibria.

Protonation states of amino acid residues.

Buffers.

Buffering in the cardiovascular system.

4.1 Research Direction: Proton coupled electron transfer and pathways.

5. Oxidation/reduction reactions and bioenergetics.

Oxidation/reduction reactions.

Electrochemical cells.

The Nernst Equation:.

Midpoint potentials.

Gibbs energy of formation and activity.

Ionic strength.

Adenosine triphosphate,ATP.

Chemiosmotic hypothesis.

5.1 Research Direction: Respiratory chain.

5.2 Research Direction: ATP synthase.

6. Kinetics and enzymes.

The rate of a chemical reaction.

Parallel first-order reactions.

Sequential first order reactions.

Second-order reactions.

The order of a reaction.

Reactions that approach equilibrium.

Activation energy.

6.1 Research Direction: Electron transfer I: Energetics.

Derivative box Derivation of Marcus relationship.

Enzymes.

Enzymes lower the activation energy.

Enzyme mechanisms.

6.2 Research Directions: Dynamics in enzyme mechanism.

Michaelis-Menten mechanism.

Lineweaver-Burk equation.

Enzyme activity.

6.3 Research direction: The RNA world.

7. The Boltzmann distribution and statistical thermodynamics.

Probability.

Boltzmann distribution.

Partition function.

Statistical thermodynamics.

7.1 Research Direction: Protein folding and prions.

Prions.

8. Quantum theory: Introduction and principles.

Classical concepts.

Experimental failures of classical physics.

Blackbody radiation.

Photoelectric effect.

Atomic spectra.

Principles of quantum theory.

Wave Particle Duality.

Schrödinger’s Equation.

Born Interpretation.

General approach for solving Schrödinger’s equation.

Interpretation of quantum mechanics.

Heisenberg Uncertainty Principle.

A quantum mechanical world.

8.1 Research Direction: Schrödinger’s cat.

9. Particle in box and tunneling.

One-dimensional particle in the box.

Properties of the solutions.

Energy and wavefunction.

Symmetry.

Wavelength.

Probability.

Average or expectation value.

Transitions.

9.1 Research Direction: Carotenoids.

Two-dimensional particle in a box.

Tunneling.

9.2 Research Direction: Probing biological membranes.

9.3 Research Direction: Electron transfer II: Distance dependence.

10. Vibrational motion and infrared spectroscopy.

Simple Harmonic Oscillator: Classical theory.

Potential energy for the simple harmonic oscillator.

Simple Harmonic Oscillator: Quantum theory.

Derivative box: Solving Schrodinger’s equation for the simple harmonic oscillator.

Properties of the wavefunctions.

Energy and wavefunction.

Forbidden region.

Transitions.

Vibrational Spectra.

10.1Research Direction: Hydrogenase.

11. Atomic structure: Hydrogen atom and Multi-electron atoms.

Schrodinger’s equation for the hydrogen atom.

Derivative box: Solving Schrodinger’s equation for the hydrogen.

Separation of variables.

Angular Solution.

Radial solution.

Properties of the general solution.

Angular Momentum.

Orbitals.

s-orbitals.

p-orbitals.

d-orbitals.

Transitions.

11.1 Research Direction: Hydrogen economy.

Spin.

Derivative box:Relativistic equations.

Many electron atoms.

Empirical constants.

Self-consistent field theory (Hartree-Fock).

Helium atom.

Spin-orbital coupling.

Periodic table.

12. Chemical bonds and protein interactions.

Schrodingers’ equation for the hydrogen molecule.

Valence bonds.

Huckel model.

Interactions in proteins.

Peptide bonds.

Steric effects.

Hydrogen bonds.

Electrostatic interactions.

Hydrophobic effects.

Secondary structure.

Determination of secondary structure using circular dichroism.

12.1 Research Direction: Modeling protein structures.

13. Electronic Transitions and optical spectroscopy.

The nature of light.

The Beer-Lambert law.

Measuring absorption.

Transitions.

Derivation box: Relationship between the Einstein coefficient.

Lasers.

Selection Rules.

Franck Condon Principle.

The Relationship Between Emission and Absorption Spectra.

The yield of fluorescence.

Fluorescence Resonance Energy Transfer: FRET.

Measuring fluorescence.

Phosphorescence.

13.1 Research Direction: Probing Energy transfer using 2D optical spectroscopy.

13.2 Research Direction: Single molecule spectroscopy.

Holliday junctions.

14. X-ray diffraction and EXAFS.

Diffraction theory.

Bragg’s Law.

Bravais lattices.

Protein crystals.

Diffraction from Crystals.

Derivative box: Phases of complex numbers.

Phase determination.

Molecular Replacement.

Isomorphous Replacement.

Anomalous Dispersion.

Model Building.

Experimental measurement of X-ray diffraction.

Examples of protein structures.

14.1 Research Direction: Nitrogenase.

EXAFS.

15. Magnetic resonance.

Nuclear magnetic resonance.

Chemical shifts.

Spin-spin interactions.

Pulse techniques.

Two dimensional NMR:Nuclear Overhauser effect.

NMR spectra of amino acids.

15.1 Research Direction: Development of new NMR techniques.

15.2 Research Direction: Spinal Muscular Atrophy.

Magnetic Resonance Imaging (MRI).

Electron Spin Resonance.

Hyperfine structure.

Spin probes.

ENDOR.

15.3 Research Direction: heme proteins.

15.4 Research Direction: ribonucleotide reductase.

16. Signal transduction.

Biochemical pathway for visual response.

Spectroscopic studies of rhodopsin.

Bacteriorhodopsin.

Structural studies.

Comparison of rhodopsins from different organisms.

Rhodopsin proteins in visual response.

17. Membrane potentials, transporters, and channels.

Membrane potentials.

Energetics of transport across membranes.

Transporters.

Ion channels.

18. Molecular imaging.

Green fluorescent protein,GFP.

Mechanism of chromophore formation.

FRET: fluorescence resonance energy transfer.

Imaging of GFP in cells.

Imaging in organisms.

Radioactive decay.

Positron emission tomography.

Parkinson’s disease.

19. Photosynthesis.

Energy transfer and light-harvesting complexes.

Electron transfer, bacterial reaction centers, and photosystem I.

Water oxidation

Product Details

ISBN:
9781405124362
Author:
Allen, James P.
Publisher:
Wiley-Blackwell
Author:
Allen, James
Author:
Allen, Lindsey Ed. P.A. Ed. J. Ed. Eliza
Author:
Allen
Subject:
Life Sciences - Biology - General
Subject:
Biophysics
Subject:
Biochemistry
Subject:
Life Sciences - Biochemistry
Subject:
Life Sciences - Biophysics
Subject:
Chemistry - Physical & Theoretical
Subject:
Biochemistry (Chemical Biology)
Subject:
Chemistry-Biochemistry
Copyright:
Publication Date:
September 2008
Binding:
HARDCOVER
Grade Level:
Professional and scholarly
Language:
English
Illustrations:
Y
Pages:
512
Dimensions:
254 x 195.5 x 26.9 mm 45 oz

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Biophysical Chemistry New Hardcover
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Product details 512 pages Wiley-Blackwell - English 9781405124362 Reviews:
"Synopsis" by , James Allen is a professor at Arizona State University. He has won numerous honors including several study sections with the National Institutes for Health and was selected for Who’s Who Among America’s Teachers.
"Synopsis" by , Biophysical Chemistry presents physical chemistry through the use of biological and biochemical topics, examples, and applications to biochemistry. It presents a rigorous, up-to-date treatment of the material without presuming a strong prior knowledge of math theory. Necessary calculus models are laid out in a step-by-step fashion for students less confident in their math abilities. The format of the text allows teachers ample flexibility in deciding which derivations to present in class. Students are guided through an in-depth understanding of fundamental concepts – such as a quantum-mechanical description of the hydrogen atom – and techniques are presented with an emphasis on learning through analysis of real data. Cases are drawn from timely research areas in biochemistry using an integrated approach to problem solving. Every chapter features important recent advances in biochemistry, an examination of current research problems, math and derivation boxes to guide students, and examples of both numerical and concept-based problems. Artwork from the book is available for download by instructors at www.blackwellpublishing.com/allenbiophysical
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