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Original Essays | April 18, 2013
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Lysophospholipid Receptors: Signaling and Biochemistryby Jerold Chun
Synopses & ReviewsPublisher Comments:The current state of the science supporting new research in lysophospholipids
The study of lysophospholipids exploded with the discovery of cell surface receptors on both lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Since then, thousands of original research reports—ranging from fundamental cell signaling to the physiology and pathophysiology of individual organ systems—have centered on lysophospholipids. This book draws together and analyzes the current literature to provide readers with a state-of-the-science review as well as current techniques that support research in all aspects of the field of lysophospholipid signaling. Lysophospholipid Receptors is divided into three sections:
Within each section, the authors explain the similarities and differences between LPA and S1P signaling. Examples are provided that demonstrate the underlying mechanisms of lysophospholipid signaling across a broad range of organ systems, such as S1P signaling in cardiovascular physiology and disease and the neural effects of LPA signaling. Extensive references at the end of each chapter provide a gateway to the literature and facilitate further research into individual topics. Each chapter has been authored by one or more leading international authorities in lysophospholipid research. Based on a thorough analysis of the current research, the authors set forth what is established science and offer their expert opinion and perspective on new and emerging areas of research, setting the stage for further investigations that will solve current problems in the field. Synopsis:This state-of-the-art reference addresses lysophospholipids, a special kind of fat that has been found to have a growing number of receptors within the cell and that has important, natural roles in the body, being essential for normal reproduction, development, maturation and life. This book covers the biochemistry, interactions, and signaling of lysophospholipids as well as its potential for producing new therapies for a range of medically important human diseases. Bringing together current knowledge in lysophospholipid signaling, this represents a must-have book for all academic, industrial, and medical school and hospital libraries.
About the AuthorJEROLD CHUN, MD, PhD, is a Professor at The Scripps Research Institute in La Jolla, California, and is a pioneer in the field of lysophospholipid signaling.
Table of ContentsPREFACE ix
CONTRIBUTORS xi 1 LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR SIGNALING 1 2 SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTORS 41 3 GLOBAL GENE EXPRESSION PROGRAM OF LYSOPHOSPHATIDIC ACID (LPA)-STIMULATED FIBROBLASTS 61 4 IDENTIFICATION OF DIRECT INTRACELLULAR TARGETS OF SPHINGOSINE 1-PHOSPHATE (S1P) 71 5 LYSOPHOSPHOLIPID RECEPTOR SIGNALING PLATFORMS: THE RECEPTOR TYROSINE KINASE–G PROTEIN-COUPLED RECEPTOR SIGNALING COMPLEX 85 6 AUTOTAXIN: A UNIQUE ECTO-TYPE PYROPHOSPHODIESTERASE WITH DIVERSE FUNCTIONS 103 7 STUDIES ON AUTOTAXIN SIGNALING IN ENDOCYTIC VESICLE BIOGENESIS AND EMBRYONIC DEVELOPMENT USING WHOLE EMBRYO CULTURE AND ELECTROPORATION 121 8 STANDARDIZATION AND QUANTIFICATION OF LYSOPHOSPHATIDIC ACID COMPOUNDS BY NORMAL-PHASE AND REVERSED-PHASE CHROMATOGRAPHY–TANDEM MASS SPECTROMETRY 137 9 SPHINGOSINE KINASES: BIOCHEMISTRY, REGULATION, AND ROLES 153 10 FUNCTIONAL AND PHYSIOLOGICAL ROLES OF SPHINGOSINE 1-PHOSPHATE TRANSPORTERS 185 11 LIPID PHOSPHATE PHOSPHATASES AND SIGNALING BY LYSOPHOSPHOLIPID RECEPTORS 201 12 LIPID PHOSPHATE PHOSPHATASES: RECENT PROGRESS AND ASSAY METHODS 229 13 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND CARDIOVASCULAR PATHOLOGY 265 14 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING IN CARDIOVASCULAR PHYSIOLOGY AND DISEASE 283 15 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING AND THE VASCULATURE 313 16 REGULATION OF THE NUCLEAR HORMONE RECEPTOR PPARγ BY ENDOGENOUS LYSOPHOSPHATIDIC ACIDS (LPAS) 349 17 MECHANISMS AND MODELS FOR ELUCIDATING THE CARDIAC EFFECTS OF SPHINGOSINE 1-PHOSPHATE (S1P) 373 18 NEURAL EFFECTS OF LYSOPHOSPHATIDIC ACID (LPA) SIGNALING 399 19 WIDESPREAD EXPRESSION OF SPHINGOSINE KINASES AND SPHINGOSINE 1-PHOSPHATE (S1P) LYASE SUGGESTS DIVERSE FUNCTIONS IN THE VERTEBRATE NERVOUS SYSTEM 419 20 LYSOPHOSPHATIDIC ACID AND NEUROPATHIC PAIN: DEMYELINATION AND LPA BIOSYNTHESIS 433 21 ROLE OF LYSOPHOSPHATIDIC ACID (LPA) IN BEHAVIORAL PROCESSES: IMPLICATIONS FOR PSYCHIATRIC DISORDERS 451 22 SPHINGOSINE 1-PHOSPHATE (S1P) SIGNALING AND LYMPHOCYTE EGRESS 475 23 BIOLOGY REVEALED BY SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR GENE-ALTERED MICE 489 24 ROLE OF LYSOPHOSPHATIDIC ACID (LPA) IN THE INTESTINE 507 25 LYSOPHOSPHOLIPID SIGNALING IN FEMALE AND MALE REPRODUCTIVE SYSTEMS 529 26 THE GONADS AND THEIR MAGIC BULLET, LYSOPHOSPHATIDIC ACID: PHYSIOLOGICAL AND TOXICOLOGICAL FUNCTIONS OF LYSOPHOSPHATIDIC ACID (LPA) IN FEMALE AND MALE REPRODUCTIVE SYSTEMS 569 27 LYSOPHOSPHOLIPID REGULATION OF LUNG FIBROSIS 587 28 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND BONE 609 29 LYSOPHOSPHATIDIC ACID (LPA) SIGNALING AND BONE CANCER 627 30 UNDERSTANDING THE FUNCTIONS OF LYSOPHOSPHATIDIC ACID RECEPTORS IN CANCER 641 31 LYSOPHOSPHATIDIC ACID RECEPTORS IN CANCER 661 32 LPA RECEPTOR SUBTYPES LPA1 AND LPA2 AS POTENTIAL DRUG TARGETS 681 33 CLINICAL INTRODUCTION OF LYSOPHOSPHATIDIC ACID (LPA) AND AUTOTAXIN ASSAYS 709 34 ANTIBODIES TO BIOACTIVE LYSOPHOSPHOLIPIDS 737 INDEX 753 What Our Readers Are SayingBe the first to add a comment for a chance to win!Product Details
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