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Chemical Biology: Approaches to Drug Discovery and Development to Targeting Diseaseby Natanya Civjan
Synopses & Reviews
An authoritative look at the application of chemical biology in drug discovery and development
Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases.
Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including:
Chemical Biology is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.
Based on the award winning Wiley Encyclopedia of Chemical Biology, this book comprises 22 carefully selected reprints, as well as new contributions from leading scholars in the field, providing a fairly general overview of the role of chemical biology in drug discovery and development and in understanding biological mechanisms of common diseases.
Part I of the book focuses on the role of chemical biology in drug discovery and drug development, computational approaches, design and selection of small molecule inhibitors, lead optimization, and pharmacokinetics of drug candidates.
Part II discusses the role of chemical biology in elucidating biological mechanisms and in treating disease including HIV, allergy and asthma, osteoarthritis, chronic obstructive pulmonary disease, anxiety disorder, depression, schizophrenia, and more.
About the Author
NATANYA CIVJAN, PhD, is a freelance editor with a doctorate in biochemistry. Formerly with John Wiley & Sons, she developed and edited the Wiley Encyclopedia of Chemical Biology and was part of the team responsible for the Wiley Interdisciplinary Reviews, which won top prizes in publishing from the American Publishers Awards for Professional and Scholarly Excellence.
Table of Contents
PART I DRUG DISCOVERY AND DEVELOPMENT 1
1 The Role of Chemical Biology in Drug Discovery 3
2 Computational Approaches to Drug Discovery and Development 23
3 Design and Selection of Small Molecule Inhibitors 41
4 Lead Optimization in Drug Discovery 65
5 Pharmacokinetics of Drug Candidates 83
6 ADME Properties of Drugs 101
7 Drug Transport in Living Systems 115
8 Blood-Brain Barrier: Considerations in Drug Development and Delivery 133
9 Pharmacokinetic Considerations: Methods and Systems of Controlled Drug Delivery 147
10 Pharmaceuticals: Natural Products and Natural Product Models 165
PART II CHEMICAL BIOLOGY TO UNDERSTAND AND TARGET DISEASE 203
11 The Role of Chemical Biology in Understanding and Treating
12 Anxiety Disorders 215
13 Chronic Obstructive Pulmonary Disease (COPD) 245
14 Depression 267
15 Osteoarthritis 293
16 Human Immunodeficiency Virus (HIV) 331
17 Allergy and Asthma 341
18 Schizophrenia 357
19 Protein Misfolding and Disease 379
20 Protein Trafficking Diseases 401
21 Metabolic Diseases 419
22 Mitochondrial Medicine 445
23 Lysosomal Disorders 461
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