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Enzyme Catalysis in Organic Synthesis

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Synopses & Reviews

Publisher Comments:

Reviews for previous editions of Enzyme Catalysis in Organic Synthesis include: "an unrivalled wealth of knowledge and experience... destined to become known as "The Handbook" for biological catalysis in organic chemistry", and "this book sets the standard in the field." This completely new edition is considerably extended, and fully updated and presents the insight of numerous world-leading practitioners.

The use of enzymes in organic synthesis in both academia and industry has changed from being a seldom-used technique to common practice. The power of the technology results in novel transformations, better enzymes, a wide variety of applications, and the unprecedented development of biocatalysts through the ongoing integration of molecular biology methodology in organic synthesis. This book explains how and why enzymatic catalysis has developed into the crucial synthetic tool for the chemist that it is.

A major driver in research and development in the chemical industry is to employ environmentally friendly processes, often named "green" or "sustainable". Synthetic biology is also facilitated by enzyme catalysis which offers fascinating opportunities in this respect and is, and will continue to be, one of the most important tools available to scientists aiming to maintain product and process development while protecting the environment and its resources.

The new edition of this renowned handbook retains the classification of biocatalytic transformations by reaction type, and this comprehensive three-volume set guides the user through the latest innovations, provides analysis of important new trends, and will be an indispensable companion for all practitioners of chemical synthesis.

Herbert Waldmann, a pioneer in the field, comments in his foreword of this third edition: "It is not only an invaluable source of knowledge and references, it also embodies a treasure that consists of a multitude of findings not yet exploited by the scientific community." A must-have for all scientists working in (bio)catalysis and modern organic chemistry.

Synopsis:

Optimized by nature over the millennia, enzymes are catalysts that play a crucial role in the transformation and degradation of essential molecules in living organisms. Biocatalysis and biotransformations have been part of our daily lives for thousands of years, two obvious examples being the production of wine and vinegar. Most of the enzymes used in biocatalysis today are of microbial origin (bacteria, fungi or yeast), while a few are of plant or mammal origin.

Edited by a highly knowledgeable team with a tremendous amount of experience in organic synthesis, catalysis and biocatalysis as well as their applications, this new edition retains the successful concept of its predecessors, while the contents are very much focused on new developments in the field.

From the contents:

* Concepts in biocatalysis

* Discovery of enzymes

* Rational design of enzymes

* Directed evolution of enzymes

* Production of enzymes

* Reaction and process engineering

* Hydrolysis and formation of C-O BONDS

* Hydrolysis and formation of C-N BONDS

* Formation and cleavage of C-C-BONDS

* Reductions

* Oxidations

All the techniques described are directly transferable from the lab to the industrial scale, making for a very application-oriented approach.

A must for all chemists and biotechnologists, this is the standard reference in the field.

Synopsis:

This comprehensive three-volume set is the standard reference in the field of organic synthesis, catalysis and biocatalysis.

Edited by a highly experienced and highly knowledgeable team with a tremendous amount of experience in this field and its applications, this edition retains the successful concept of past editions, while the contents are very much focused on new developments in the field.

All the techniques described are directly transferable from the lab to the industrial scale, making for a very application-oriented approach.

A must for all chemists and biotechnologists.

About the Author

Karlheiz Drauz is Vice President International Scientific Relations of Evonik. He evaluates interesting topics in research and development and networks globally with academic and industrial institutions. He did his Ph.D. at the Technical University Stuttgart, Germany, and started his career at Degussa 1980 in various positions in research and development. Amoungst his research interests are amino acids, peptides, biological active compounds, asymmetric synthesis, metal and biocatalysis as well as process chemistry. He holds about 160 patents, about 100 scientific publications. Since 1992 he is honorary professor for organic chemistry at the University Würzburg, Germany.

Harald Gröger is since 2006 Professor for organic chemistry at the University of Erlangen-Nürnberg, Germany. He studied chemistry at the Universities of Erlangen-Nürnberg and Oldenburg, before he did his postdoc with Masakatsu Shibasaki at the University of Tokyo. He worked from 1998 to 2006 in industry, e.g. as senior project manager for White Biotechnology of Degussa. He received several awards, like the Degussa innovation prize for new products (2003) and for new and optimized processes (2005), the Thieme award in 2007 and the German business sectors innovation prize (2004). His research interests are enzyme catalyzed organic synthesis, design and use of biomimetic chemocatalysts as well as sustainable chemistry.

Oliver May is Competence Manager Biocatalysis and responsible for coordinating biocatalysis related activities of DSM Pharmaceutical Products. Before joining DSM in April 2006, he was with Degussa (now Evonik) in various functions; latest as General Manager of Degussa's Service Center Biocatalysis. He was educated in Germany, receiving a PhD degree in Technical Biology from the University of Stuttgart where he worked at the Institute of Biochemical Engineering for Prof. C. Syldatk and at the German Center for Biotechnology in Braunschweig with Prof. D. Schomburg. He joined Caltech as a postdoc in 1998 where he worked until 2000 in the group of Prof. F.H. Arnold on directed evolution of enzymes. Oliver May has authored more than 30 scientific contributions in Journals and Books and more than 15 patent applications. He his team was awarded several innovation awards on hydantoinase technology, whole-cell processes and the latest on recombinant pig liver esterase in its application for production of a pharma intermediate.

Table of Contents

INTRODUCTION

CONCEPTS IN BIOCATALYSIS

DISCOVERY OF ENZYMES

RATIONAL DESIGN OF ENZYMES

DIRECTED EVOLUTION OF ENZYMES

PRODUCTION OF ENZYMES

REACTION AND PROCESS ENGINEERING

HYDROLYSIS AND FORMATION OF C-O BONDS

Hydrolysis and Formation of Carboxylic Acid Esters

Hydrolysis and Formation of Epoxides

Hydrolysis and Formation of Glycosidic Bonds

Addition and Elimination of Water to C=C Bonds

HYDROLYSIS AND FORMATION OF C-N BONDS

Hydratation of Nitriles to Amides

Hydratation of Nitriles to Acids

Hydrolysis of Amides

Hydrolysis and Formation of Hydantoins

Hydrolysis and Formation of Peptides

Addition of Ammonia and Amines to C=C Bonds

Transaminases in Organic Synthesis

FORMATION AND CLEAVAGE OF C-C-BONDS

Aldolreactions

Acyloin- and Benzoin Condensations

Cleavage and Formation of Cyanohydrines

Hydrolysis and Formation of P-O Bonds

REDUCTIONS

Ketones and Aldehydes to Alcohols

Enzymatic Reduction of C=C-Double Bonds

Reductive Aminations

OXIDATIONS

Oxifunctionalization of C-H Bonds

Oxifunctionalization of C-C-Multiple Bonds

Oxidation of Alcohols, Aldehydes and Acids

Baeyer-Villiger-Oxidations

Oxidation of Aromatic Compounds

Oxidation of C-N Bonds

Oxidation at Sulfur and Oxidation of Amino Groups

Halogenation

Isomerizations

MISCELLANEOUS

Enzymatic Promiscuity

Catalytic Antibodies

Coupled Enzyme Reactions and Pathway Engineering

Combined Chemo-Enzymatic Reactions

Biocatalysis in Material Sciences

TABULAR SURVEY OF AVAILABLE ENZYMES

Product Details

ISBN:
9783527325474
Author:
Drauz, Karlheinz
Publisher:
Wiley-Vch
Author:
ger
Author:
Gr?ger, Harald
Author:
ouml
Author:
May, Oliver
Author:
Gr
Author:
ger, Harald
Author:
Harald Gr
Author:
&
Subject:
Chemistry - Organic
Subject:
Organic chemistry
Subject:
catalzed reactions, industrial chemistry, enzymes as catalysts, industrial biocatalysis, biotechnology, biochemistry, green chemistry, sustainable chemistry
Subject:
catalzed reactions,
Subject:
industrial chemistry, enzymes as catalysts, industrial biocatalysis, biotechnology, biochemistry, green chemistry, sustainable chemistry
Copyright:
Edition Description:
WOL online Book (not BRO)
Publication Date:
20120327
Binding:
HARDCOVER
Language:
English
Pages:
2038
Dimensions:
240 x 120 x 170 mm 159 oz

Related Subjects

Health and Self-Help » Health and Medicine » Anatomy and Physiology
Science and Mathematics » Chemistry » Biochemistry
Science and Mathematics » Chemistry » Chemical Engineering
Science and Mathematics » Chemistry » Organic
Science and Mathematics » Electricity » General Electronics

Enzyme Catalysis in Organic Synthesis New Hardcover
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Product details 2038 pages Wiley-VCH Verlag GmbH - English 9783527325474 Reviews:
"Synopsis" by , Optimized by nature over the millennia, enzymes are catalysts that play a crucial role in the transformation and degradation of essential molecules in living organisms. Biocatalysis and biotransformations have been part of our daily lives for thousands of years, two obvious examples being the production of wine and vinegar. Most of the enzymes used in biocatalysis today are of microbial origin (bacteria, fungi or yeast), while a few are of plant or mammal origin.

Edited by a highly knowledgeable team with a tremendous amount of experience in organic synthesis, catalysis and biocatalysis as well as their applications, this new edition retains the successful concept of its predecessors, while the contents are very much focused on new developments in the field.

From the contents:

* Concepts in biocatalysis

* Discovery of enzymes

* Rational design of enzymes

* Directed evolution of enzymes

* Production of enzymes

* Reaction and process engineering

* Hydrolysis and formation of C-O BONDS

* Hydrolysis and formation of C-N BONDS

* Formation and cleavage of C-C-BONDS

* Reductions

* Oxidations

All the techniques described are directly transferable from the lab to the industrial scale, making for a very application-oriented approach.

A must for all chemists and biotechnologists, this is the standard reference in the field.

"Synopsis" by , This comprehensive three-volume set is the standard reference in the field of organic synthesis, catalysis and biocatalysis.

Edited by a highly experienced and highly knowledgeable team with a tremendous amount of experience in this field and its applications, this edition retains the successful concept of past editions, while the contents are very much focused on new developments in the field.

All the techniques described are directly transferable from the lab to the industrial scale, making for a very application-oriented approach.

A must for all chemists and biotechnologists.

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