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Genomic Perl

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Genomic Perl Cover

 

Synopses & Reviews

Publisher Comments:

This introduction to computational molecular biology will help programmers and biologists learn the skills needed to start work in this important, expanding field. The author explains many of the basic computational problems and gives concise, working programs to solve them in the Perl programming language. With minimal prerequisites, the author explains the biological background for each problem, develops a model for the solution, then introduces the Perl concepts needed to implement the solution. The book covers pairwise and multiple sequence alignment, fast database searches for homologous sequences, protein motif identification, genome rearrangement, physical mapping, phylogeny reconstruction, satellite identification, sequence assembly, gene finding, and RNA secondary structure. The concrete examples and step-by-step approach make it easy to grasp the computational and statistical methods, including dynamic programming, branch-and-bound optimization, greedy methods, maximum likelihood methods, substitution matrices, BLAST searching, and Karlin-Altschul statistics. Perl code is provided on the accompanying CD.

Synopsis:

This book explains how to write Perl computer programs to process the DNA data and other kinds of data coming from the Human Genome Project and similar sources. With minimal prerequisites, the author explains the biological background for many of the basic computational problems arising in molecular biology, develops models for their solution, then introduces the Perl concepts needed to implement those solutions. Programmers and biologists alike can use this book to prepare themselves to work in this exciting field. Perl code is provided on the accompanying CD.

Synopsis:

In this introduction to computational molecular biology, Rex Dwyer explains many basic computational problems and gives concise, working programs to solve them in the Perl programming language. With minimal prerequisites, he covers the biological background for each problem, develops a model for the solution, and then introduces the Perl concepts needed to implement the solution. The chapters discuss pairwise and multiple sequence alignment, fast database searches for homologous sequences, protein motif identification, genome rearrangement, physical mapping, phylogeny reconstruction, satellite identification, sequence assembly, gene finding, and RNA secondary structure. Concrete examples and a step-by-step approach enable readers to grasp the computational and statistical methods.

Synopsis:

Explains many computational molecular biology problems and how to implement solutions to them in Perl.

Table of Contents

1. The central dogma; 2. RNA secondary structure; 3. Comparing DNA sequences; 4. Statistical models; 5. Substitution matrices for amino acids; 6. Sequence databases; 7. Local alignment and the BLAST heuristic; 8. Statistics of BLAST database searches; 9. Multiple sequence alignment I; 10. Multiple sequence alignment II; 11. Phylogeny reconstruction; 12. Protein motifs and PROSITE; 13. Fragment assembly; 14. Coding sequence prediction with dicodon frequencies; 15. Satellite identification; 16. Restriction mapping; 17. Hybridization mapping; 18. Genome rearrangement: gates and hurdles; 19. Now what?; Appendix A: drawing RNA cloverleaves; Appendix B: space-saving strategies for alignment; Appendix C. a data structure for disjoint sets; Appendix D. a data structure for set operations.

Product Details

ISBN:
9780511057069
Publisher:
Cambridge University Press
Subject:
Computer Science
Author:
Dwyer, Rex A.
Subject:
Programming Languages - General
Subject:
Application Software - General
Subject:
Computer Architecture - General
Subject:
Computers-Computer Architecture - General
Subject:
Computers-Programming Languages - General
Subject:
Computers-Computer Science
Subject:
Computers : Computer Architecture - General
Subject:
Computers : Computer Science
Subject:
Computers : Programming Languages - General
Subject:
Computers : Systems Architecture - General
Publication Date:
February 1999
Binding:
eBooks
Language:
English
Pages:
352

Related Subjects

Computers and Internet » Computer Architecture » General
Computers and Internet » Computers Reference » General
Computers and Internet » Personal Computers » General
Computers and Internet » Software Engineering » Programming and Languages

Genomic Perl
0 stars - 0 reviews
$ In Stock
Product details 352 pages Cambridge University Press - English 9780511057069 Reviews:
"Synopsis" by , This book explains how to write Perl computer programs to process the DNA data and other kinds of data coming from the Human Genome Project and similar sources. With minimal prerequisites, the author explains the biological background for many of the basic computational problems arising in molecular biology, develops models for their solution, then introduces the Perl concepts needed to implement those solutions. Programmers and biologists alike can use this book to prepare themselves to work in this exciting field. Perl code is provided on the accompanying CD.
"Synopsis" by , In this introduction to computational molecular biology, Rex Dwyer explains many basic computational problems and gives concise, working programs to solve them in the Perl programming language. With minimal prerequisites, he covers the biological background for each problem, develops a model for the solution, and then introduces the Perl concepts needed to implement the solution. The chapters discuss pairwise and multiple sequence alignment, fast database searches for homologous sequences, protein motif identification, genome rearrangement, physical mapping, phylogeny reconstruction, satellite identification, sequence assembly, gene finding, and RNA secondary structure. Concrete examples and a step-by-step approach enable readers to grasp the computational and statistical methods.
"Synopsis" by , Explains many computational molecular biology problems and how to implement solutions to them in Perl.
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