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More copies of this ISBN:Side Effects: A Prosecutor, a Whistleblower, and a Bestselling Antidepressant on Trialby Alison Bass
Synopses & ReviewsPublisher Comments:As the mental health reporter for the Boston Globe, Alison Bass's front-page reporting on conflicts of interest in medical research stunned readers, and her series on sexual misconduct among psychiatrists earned a Pulitzer Prize nomination. Now she turns her investigative skills to a controversial case that exposed the increased suicide rates among adolescents taking antidepressants such as Paxil, Prozac, and Zoloft. Side Effectstells the tale of a gutsy assistant attorney general who, along with an unlikely whistle-blower at an Ivy League university, uncovered evidence of deception behind one of the most successful drug campaigns in history. Paxil was the world's bestselling antidepressant in 2002. Pediatric prescriptions soared, even though there was no proof that the drug performed any better than sugar pills in treating children and adolescents, and the real risks the drugs posed were withheld from the public. The New York State Attorney General's office brought an unprecedented lawsuit against giant manufacturer GlaxoSmithKline, the maker of Paxil, for consumer fraud. The successful suit launched a tidal wave of protest that changed the way drugs are tested, sold, and marketed in this country. With meticulous research, Alison Bass shows us the underbelly of the pharmaceutical industry. She lays bare the unhealthy ties between the medical establishment, big pharma, and the FDAand#8212;relationships that place vulnerable children and adults at risk every day. Review:"This densely researched report adds to the growing literature on Big Pharma's efforts to sell blockbuster drugs and with its two crusading heroes seems ready for Hollywood. Expanding on her reporting for the Boston Globe, Bass focuses on psychiatrist Martin Teicher, who as early as 1988 noticed that the antidepressant Prozac seemed paradoxically to cause suicidal thoughts in his patients, and the nearly blind Rose Firestein, a lawyer in the New York State attorney general's office who was investigating the inappropriate marketing and use of Paxil for unapproved purposes. Drug companies insisted there was 'no scientific evidence whatsoever' linking GlaxoSmithKline's Paxil, Ely Lilly's Prozac and other serotonin-increasing antidepressants to suicidal thoughts and behavior, and Bass describes the dogged battle to show that company researchers had deliberately suppressed the results of trials with negative outcomes. Bass also follows the story of Tonya Brooks, an unhappy teenager who attempted suicide while taking Paxil. Although the story sometimes gets lost in the details of then attorney general Eliot Spitzer's 2004 suit against GlaxoSmithKline (eventually settled for $2.5 million), this story of determined do-gooders is inspiring. (June)" Publishers Weekly (Copyright Reed Business Information, Inc.) Review:andquot;This is the riveting story of how one of the world's largest drug companies and a few university researchers on its payroll suppressed evidence that a top-selling antidepressant might actually be dangerous in adolescents. It's also the very human story of how two courageous and persistent women made sure the world learned about it. Reads like a good novel, with lessons that go well beyond this case.andquot; — Marcia Angell, M.D., Senior Lecturer in Social Medicine, Harvard Medical School, Former Editor-in-Chief, New England Journal of Medicine Review:andquot;A richly detailed account of the disgraceful self-serving ties between drug companies and the psychiatric profession, as told through stories about the heroes, villains and victims in this drama. An engrossing read and a valuable contribution to public understanding of the need for reform.andquot;--Arnold S. Relman, M.D., Professor Emeritus of Medicine and of Social Medicine, Harvard Medical School and Former Editor, New England Journal of Medicine Review:andquot;Side Effectsis a serious indictment of the pharmaceutical industry, clinical researchers, and government regulators, told in captivating prose. It makes you worry about the authenticity of the evidence that doctors use from day to day.andquot; — Dr. Jerome Kassirer, Distinguished Professor at Tufts University School of Medicine, former Editor-in-Chief of New England Journal of Medicine, and author of On the Take: How Medicine's Complicity with Big Business Can Endanger Your Health About the AuthorAlison Bass has covered medicine, science, and technology for the Boston Globeand other publications, including the Miami Herald, Psychology Today, and Technology Review. She has received top media awards from the National Mental Health Association and the National Alliance for the Mentally Ill, and an Associated Press First Place Award. She has taught journalism courses at Boston and Brandeis universities and lives in Newton, Massachusetts. What Our Readers Are SayingBe the first to add a comment for a chance to win!Product Details
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