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Chemical Analysis #1075: Analysis and Purification Methods in Combinatorial Chemistryby Bing Yan
Synopses & Reviews
Quality measurement, control, and improvement incombinatorial chemistry
Combinatorial chemistry has developed rapidly in the past decade, with greatadvances made by scientists working on analysis and purification of a largenumber of compounds and the analysis of polymer-bound compounds. However,formidable challenges lie ahead of today's researcher. For example,high-throughput analysis and purification technologies must be furtherdeveloped to ensure combinatorial libraries are "purifiable," and "drugable."
To this end, Analysis and Purification Methods inCombinatorial Chemistry describes various analytical techniques and systems forthe development, validation, quality control, purification, and physicochemicaltesting of combinatorial libraries. A new volume in Wiley's Chemical Analysisseries, this text has four parts covering:
Drawing from the contributions of respected experts incombinatorial chemistry, this comprehensive book provides coverage ofapplications of Nuclear Magnetic Resonance (NMR), liquid chromatography/massspectrometry (LC/MS), Fourier Transform Infrared (FTIR), micellarelectrokinetic chromatography (MEKC) technologies, as well as other analyticaltechniques.
This eminently useful volume is an essential addition to thelibrary of students and researchers studying or working in analyticalchemistry, combinatorial chemistry, medicinal chemistry, organic chemistry,biotechnology, biochemistry, or biophysics.
Book News Annotation:
Yan (a chemist with Discovery Partners International, Inc.) presents 17 papers on methods of purification and analysis that can ensure that combinatorial libraries are "synthesizable," purifiable," and "drugable." Approaches for monitoring reactions on solid support and reaction optimization for library synthesizing NMR analysis and other methods occupy opening chapters. High-throughput analysis of combinatorial library qualities is discussed before explorations of various high-throughput purification techniques are presented. Finally, analytical methods used in postsynthesis and postpurification are described.
Annotation ©2004 Book News, Inc., Portland, OR (booknews.com)
This eminently useful volume is an essential addition to the library of students and researchers studying or working in analytical chemistry, combinatorial chemistry, medicinal chemistry, organic chemistry, biotechnology, biochemistry, or biophysics.
About the Author
BING YAN, PhD, was born in China and received his PhD inchemistry at Columbia University in 1990. He then worked at CambridgeUniversity and the University of Texas-Houston Medical School as a postdoctoralfellow. From 1993 to 1999, he worked for Novartis in the Core Technologies areaof preclinical research in New Jersey. He is currently at the DiscoveryChemistry division of Discovery Partners International, Inc., in San Francisco.His major research interests are drug discovery, optimization of solid-phaseand solution-phase combinatorial synthesis, high-throughput quantitative andqualitative analysis, and high-throughput purification of combinatoriallibraries. He has written four books and published over seventy reviews andresearch articles.
Table of Contents
PART I: ANALYSIS FOR FEASIBILITY AND OPTIMIZATION OF LIBRARY SYNTHESIS.
Chapter 1. Quantitative Analysis in Organic Synthesis with NMR (L. Lucas & C. Larive).
Chapter 2. 19F Gel-phase NMR Spectroscopy for Reaction Monitoring and Quantification of Resin Loading (J. Salvino).
Chapter 3. The Application of Single-Bead FTIR and Color Test for Reaction Monitoring and Building Block Validation in Combinatorial Library Sysnthesis(J. Cournoyer, et al.).
Chapter 4. HR-MAS NMR Analysis of Compounds Attached to Polymer Supports (M. Guinó & Y. de Miguel).
Chapter 5. Multivariate Tools for Real-Time Monitoring and Optimization of Combinatorial Materials and Process Conditions (R. Potyrailo, et al.).
Chapter 6. Mass Spectrometry and Soluble Polymeric Supports (C. Enjalbal, et al.).
PART II: HIGH-THROUGHPUT ANALYSIS FOR LIBRARY QUALITY CONTROL.
Chapter 7. High-Throughput NMR Techniques for Combinatorial Chemical Library Analysis (T. Hou & D. Raftery).
Chapter 8. Micellar Electrokinetic Chromatography as a Tool for Combinatorial Chemistry Analysis: Theory and Applications (P. Simms).
Chapter 9. Characterization of Split-Pool Encoded Combinatorial Libraries (J. Zhang & W. Fitch).
PART III: HIGH-THROUGHPUT PURIFICATION TO IMPROVE LIBRARY QUALITY.
Cha pter 10. Strategies and Methods for Purifying Organic Compounds and Combinatorial Libraries (J. Zhao, et al.).
Chapter 11. HTP of Combinatorial Chemistry Libraries (J. Hochlowski).
Chapter 12. Practical HPLC in High Throughput Analysis and Purification (H. Gumm & R. God).
PART IV: ANALYSIS FOR COMPOUND STABILITY AND DRUGABILITY.
Chapter 13. Organic Compound Stability in Large, Diverse Phatmaceutical Screening Collection (K. Morand & X. Cheng).
Chapter 14. Quartz Crystal Microbalance in Biomolecular Recognition (M. Tseng, et al.).
Chapter 15. High-Throughput Physicochemical Profiling: Potential and Limitations (B. Faller).
Chapter 16. Solubility in the Design of Combinatorial Libraries (C. Lipinski).
Chapter 17. High-Throughput Determination of Log D Values by LC/MS Method (J. Villena, et al.).
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