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Bayesian Methods and Ethics in a Clinical Trial Design (Wiley Series in Probability & Mathematical Statistics)

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Bayesian Methods and Ethics in a Clinical Trial Design (Wiley Series in Probability & Mathematical Statistics) Cover

 

Synopses & Reviews

Publisher Comments:

How to conduct clinical trials in an ethical and scientifically responsible manner

This book presents a methodology for clinical trials that produces improved health outcomes for patients while obtaining sound and unambiguous scientific data. It centers around a real-world test case—involving a treatment for hypertension after open heart surgery—and explains how to use Bayesian methods to accommodate both ethical and scientific imperatives.

The book grew out of the direct involvement in the project by a diverse group of experts in medicine, statistics, philosophy, and the law. Not only do they contribute essays on the scientific, technological, legal, and ethical aspects of clinical trials, but they also critique and debate each other's opinions, creating an interesting, personalized text.

Bayesian Methods and Ethics in a Clinical Trial Design

  • Answers commonly raised questions about Bayesian methods
  • Describes the advantages and disadvantages of this method compared with other methods
  • Applies current ethical theory to a particular class of design for clinical trials
  • Discusses issues of informed consent and how to serve a patient's best interest while still obtaining uncontaminated scientific data
  • Shows how to use Bayesian probabilistic methods to create computer models from elicited prior opinions of medical experts on the best treatment for a type of patient
  • Contains several chapters on the process, results, and computational aspects of the test case in question
  • Explores American law and the legal ramifications of using human subjects

For statisticians and biostatisticians, and for anyone involved with medicine and public health, this book provides both a practical guide and a unique perspective on the connection between technological developments, human factors, and some of the larger ethical issues of our times.

Synopsis:

JOSEPH B. KADANE is Leonard J. Savage Professor of Statistics and Social Sciences at Carnegie Mellon University. He has published over one hundred papers on statistical theory and applications, edited the book Robustness of Bayesian Analysis, and coedited Statistics and the Law.

About the Author

"...Every practitioner and associated statistician involved in a clinical trial should read this book..." (Statistical Methods in Medical Research, No.11, 2002)

Table of Contents

Partial table of contents:

MAJOR ISSUES.

Ethically Optimizing Clinical Trials (K. Schaffner).

Admissibility of Treatment (N. Sedransk).

TEST CASE: VERAPAMIL/NITROPRUSSIDE.

The Mechanics of Conducting a Clinical Trial (E. Heitmiller & T. Blanck).

Issues of Statistical Design (N. Sedransk).

Operational History and Procedural Feasibility (J. Kadane).

Verapamil versus Nitroprusside: Results of the Clinical Trial I (J. Kadane & N. Sedransk).

Verapamil versus Nitroprusside: Results of the Clinical Trial II (E. Heitmiller, et al.).

OTHER ISSUES.

Author's Response to Commentaries I and II (D. Kairys).

EPILOGUE.

Epilogue (J. Kadane).

Indexes.

Product Details

ISBN:
9780471846802
Editor:
Kadane, Joseph B.
Publisher:
John Wiley & Sons
Editor:
Kadane, Joseph B.
Author:
Kadane, Joseph B.
Author:
Kadane
Location:
New York :
Subject:
Ethics
Subject:
Jurisprudence
Subject:
Pharmacology
Subject:
Clinical trials
Subject:
Ethics, Medical
Subject:
Jurisprudence -- United States.
Subject:
Research design.
Subject:
Bayes Theorem.
Subject:
Probability & Statistics - General
Subject:
Statistics
Subject:
Clinical medicine
Subject:
Health and Medicine-Pharmacology
Copyright:
Edition Description:
WOL online Book (not BRO)
Series:
Wiley Series in Probability and Statistics
Series Volume:
214
Publication Date:
January 1996
Binding:
HARDCOVER
Grade Level:
Professional and scholarly
Language:
English
Illustrations:
Yes
Pages:
344
Dimensions:
9.52x6.42x.96 in. 1.35 lbs.

Related Subjects

Health and Self-Help » Health and Medicine » Medical Specialties
Health and Self-Help » Health and Medicine » Pharmacology
Health and Self-Help » Health and Medicine » Professional Medical Reference
Science and Mathematics » Chemistry » Analytical
Science and Mathematics » Mathematics » Applied
Science and Mathematics » Mathematics » Probability and Statistics » General
Science and Mathematics » Mathematics » Probability and Statistics » Statistics

Bayesian Methods and Ethics in a Clinical Trial Design (Wiley Series in Probability & Mathematical Statistics) Used Hardcover
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$35.00 In Stock
Product details 344 pages Wiley-Interscience - English 9780471846802 Reviews:
"Synopsis" by , JOSEPH B. KADANE is Leonard J. Savage Professor of Statistics and Social Sciences at Carnegie Mellon University. He has published over one hundred papers on statistical theory and applications, edited the book Robustness of Bayesian Analysis, and coedited Statistics and the Law.
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