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Other titles in the Wiley Series in Probability & Mathematical Statistics series:
Bayesian Methods and Ethics in a Clinical Trial Design (Wiley Series in Probability & Mathematical Statistics)by Joseph B Kadane
Synopses & Reviews
How to conduct clinical trials in an ethical and scientifically responsible manner
This book presents a methodology for clinical trials that produces improved health outcomes for patients while obtaining sound and unambiguous scientific data. It centers around a real-world test case—involving a treatment for hypertension after open heart surgery—and explains how to use Bayesian methods to accommodate both ethical and scientific imperatives.
The book grew out of the direct involvement in the project by a diverse group of experts in medicine, statistics, philosophy, and the law. Not only do they contribute essays on the scientific, technological, legal, and ethical aspects of clinical trials, but they also critique and debate each other's opinions, creating an interesting, personalized text.
Bayesian Methods and Ethics in a Clinical Trial Design
For statisticians and biostatisticians, and for anyone involved with medicine and public health, this book provides both a practical guide and a unique perspective on the connection between technological developments, human factors, and some of the larger ethical issues of our times.
JOSEPH B. KADANE is Leonard J. Savage Professor of Statistics and Social Sciences at Carnegie Mellon University. He has published over one hundred papers on statistical theory and applications, edited the book Robustness of Bayesian Analysis, and coedited Statistics and the Law.
About the Author
"...Every practitioner and associated statistician involved in a clinical trial should read this book..." (Statistical Methods in Medical Research, No.11, 2002)
Table of Contents
Partial table of contents:
Ethically Optimizing Clinical Trials (K. Schaffner).
Admissibility of Treatment (N. Sedransk).
TEST CASE: VERAPAMIL/NITROPRUSSIDE.
The Mechanics of Conducting a Clinical Trial (E. Heitmiller & T. Blanck).
Issues of Statistical Design (N. Sedransk).
Operational History and Procedural Feasibility (J. Kadane).
Verapamil versus Nitroprusside: Results of the Clinical Trial I (J. Kadane & N. Sedransk).
Verapamil versus Nitroprusside: Results of the Clinical Trial II (E. Heitmiller, et al.).
Author's Response to Commentaries I and II (D. Kairys).
Epilogue (J. Kadane).
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