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How the Cows Turned Madby Maxime Schwartz
Synopses & Reviews
Fear of mad cow disease, a lethal illness transmitted from infected beef to humans, has spread from Europe to the United States and around the world. Originally published to much acclaim in France, this scientific thriller, available in English for the first time and updated with a new chapter on developments in 2001, tells of the hunt for the cause of an enigmatic class of fatal brain infections, of which mad cow disease is the latest incarnation. In gripping, nontechnical prose, Maxime Schwartz details the deadly manifestations of these diseases throughout history, describes the major players and events that led to discoveries about their true nature, and outlines our current state of knowledge. The book concludes by addressing the question we all want answered: should we be afraid?
The story begins in the eighteenth century with the identification of a mysterious illness called scrapie that was killing British sheep. It was not until the 1960s that scientists understood that several animal and human diseases, including scrapie, were identical, and together identified them as transmissible spongiform encephalopathy (TSE). The various guises assumed throughout history by TSE include an illness called kuru in a cannibalistic tribe in Papua New Guinea, an infectious disease that killed a group of children who had been treated for growth hormone deficiencies, and mad cow disease. Revealing the fascinating process of scientific discovery that led to our knowledge of TSE, Schwartz relates pivotal events in the history of biology, including the Pasteurian revolution, the birth of genetics, the emergence of molecular biology, and the latest developments in biotechnology. He also explains the Nobel Prize-winning prion hypothesis, which has rewritten the rules of biological heredity and is a key link between the distinctive diseases of TSE.
Up-to-date, informative, and thoroughly captivating, How the Cows Turned Mad tells the story of a disease that continues to elude on many levels. Yet science has come far in understanding its origins, incubation, and transmission. This authoritative book is a stunning case history that illuminates the remarkable progression of science.
"Do not be put off by the title, which trivializes the text. The molecular biologist Maxime Schwartz is a pillar of the French scientific establishment. Recently he was Director of the Pasteur Institute, the living embodiment of French pride in Louis Pasteur, the nineteenth-century inventor of microbiology. Now he has capped all that with a brilliant piece of science writing, How the Cows Turned Mad." John Maddox, Times Literary Supplement (read the entire TLS review)
"Schwartz's fully engrossing, two-century-plus detective story provides a thoroughgoing history of the discovery of 'mad cow' and related diseases that also illuminates the ways in which science works. I could not put this book down." Jon Beckwith, author of Making Genes, Making Waves: A Social Activist in Science
"Writing with immense concentration and clarity, French molecular biologist Schwartz makes the long hunt for the unexpected culprit gene utterly engrossing." Booklist, starred review
A gripping biological detective story that traces the history of mad cow disease and related infectious brain diseases of livestock and people. The book also illustrates dramatically how scientific progress unfolds as researchers in various countries pursue new ideas and leads in order to identify the cause of and relationship between these enigmatic diseases.
This scientific thriller tells of the hunt for the cause of an enigmatic class of fatal brain infections, including mad cow disease. In nontechnical prose, Maxime Schwartz details the deadly manifestations of these diseases throughout history. He concludes with the question: should we be afraid?
"Schwartz's fully engrossing, two-century-plus detective story provides a thoroughgoing history of the discovery of 'mad cow' and related diseases that also illuminates the ways in which science works. I could not put this book down."—Jon Beckwith, author of Making Genes, Making Waves: A Social Activist in Science
"Rarely have I read a book as scary, interesting, informative and enjoyable."—John E. Talbott, University of California, Santa Barbara
Praise for the French edition:
"Maxime Schwartz's book . . . constitutes an ode to science, to its rigor, to its perseverance, but also, as we shall see, to its modesty. How the Cows Turned Mad is a gothic historical novel: its author, molecular biologist and former director of the Pasteur Institute, leads us along a thread that unravels over almost three centuries, from Louis XV to Tony Blair."—Le Figaro
"But above all, and this is indeed remarkable in a work which treats such a scientific subject, How the Cows Turned Mad is not a scientific treatise for scientists, but rather a book. And as such, it reads easily and pleasurably."—Le Généraliste
"How the Cows Turned Mad: that's the title of this book, almost a detective novel, just published by the molecular biologist Maxime Schwartz. An indispensable tool that allows us to sort through the truths and untruths and finally assess the situation."—Panorama du médecin
About the Author
Maxime Schwartz, a molecular biologist, is Professor at the Institut Pasteur in Paris, which he headed from 1988 to 1999. He is also Director of Research at the Centre national de la recherche scientifique (CNRS) and is currently serving as Director of Laboratories of the French agency for food safety (AFSSA). He is the author of many scientific papers and Pasteur, des microbes au vaccin (1999, with Annick Perrot).
Table of Contents
1: The Sheep Are Strangely Dizzy
2: Molecules and Microbes
3: Mad Dogs and Earthworms
4: Scrapie under the Microscope
5: Creutzfeldt, Jakob, and Others
6: Scrapie Is Inoculable
7: And Goats, and Mice
8: Scrapie Is Contagious
9: Kuru and the Fore People of Papua New Guinea
10: The Wall Comes Down
11: From Pearl Necklace to Double Helix
12: The Phantom Virus
13: A Tragedy in the Making
14: One Case per Million
16: April 1985
17: The "Kiss of Death"
18: The Return of the Spontaneists
19: To Grow—and to Die
20: Lessons Learned
21: Have the Cows Gone Mad?
22: From Cows to Humans
23: From Cows to Sheep? From Humans to Humans?
24: The Secret in the Closet
25: Unmasking "The Disease"
26: Have We Conquered "The Disease"?
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