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From Egg to Embryo: Regional Specification in Early Developmentby J. M. W. Slack
Synopses & Reviews
The past decade has seen a dramatic increase in our understanding of early animal development. The revised edition of this excellent book describes the results of this revolution and explains in detail how the body plan of an embryo emerges from a newly fertilized egg. The book starts with a critical discussion of embryological concepts, and with simple mathematics describes cell states, morphogen gradients, and threshold responses. The experimental evidence of the mechanisms of regional specification in vertebrates, insects, and selected invertebrates, namely frogs (Xenopus), mice, chicks, fruitflies (Drosophila), mollusks, ringed worms, sea squirts, and nematode worms (Caenorhabditis), is then discussed. The progress with Drosophila has been particularly impressive, and there is an entire chapter devoted to it that provides a clear guide to the subject and includes a new table of developmentally important genes. Throughout, the emphasis is on conceptual clarity and unity, and the book brings together mathematical models, embryological experiments, and molecular biology in a single comprehensible and coherent account.
In the last ten years there has been a revolution in our understanding of early animal development. This latest edition explains how the body plan of an embryo emerges from a newly fertilised egg. The emphasis is on conceptual clarity and unity, bringing together mathematical models, embryological experiments and molecular biology.
Reflecting the results of the decade's dramatic progress in early animal development research, mathematical models, embryological experiments, and molecular biology more precisely trace the development of the animal embryo from the fertilized egg.
Describes our understanding of early animal development and explains how the body plan of an embryo emerges from the newly fertilised egg.
Includes bibliographical references (p. 297-321) and index.
Table of Contents
Preface to the second edition; Preface to the first edition; 1. Regional specification in animal development; 2. The concepts of experimental embryology; 3. Theoretical embryology; 4. Hierarchies of developmental decisions; 5. Development with a small cell number; 6. Models for man: the mouse and the chick; 7. The breakthrough; 8. What does it all mean?; Appendix: How to write a program for development; References; Index.
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