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Other titles in the Lezioni Lincee series:
Half a Century of Radical Chemistryby Derek H. R. Barton
Synopses & Reviews
This book describes the work of Nobel Laureate Derek Barton on the chemistry of organic free radicals, and the invention of new chemical reactions for use in the synthesis of biologically and economically important compounds. It begins with a mechanistic study of industrial significance on the pyrolysis of chlorinated alkanes. It continues with a theory on the biosynthesis of phenolate derived alkaloids involving phenolate radical coupling. The book then describes the work on nitrite photolysis (Barton reaction), which involved the invention of new radical chemistry leading to a simple synthesis of the important hormone, aldosterone. It also describes another new reaction extended to carboxlic acids that provides carbon, nitrogen, oxygen and other radicals under mild conditions. A final chapter summarizes recent applications of thiocarbonyl group derived radical reactions by other authors.
This book is about the invention of new chemical reactions for use in the synthesis of biologically and economically important compounds. The reactions invented in the last 20 years are making important contributions to industrial and university research.
An account of the Nobel Laureate author's exhaustive work with the chemistry of organic free radicals and the invention of new chemical reactions for use in the synthesis of biologically and economically important compounds.
This book describes a lifetime devoted to creative chemistry in the service of all mankind.
Table of Contents
1. The pyrolysis of chlorinated hydrocarbons; 2. Phenolate radical coupling in synthesis and biosysnthesis; Pummerer's ketone; 3. Nitrite photolysis (the Barton Reaction); 4. Radical deoxygenation(the reaction of Barton and Mc Combie); 5. Disciplined radicals and disciplinary radical reactions (Barton decarboxylation); 6. Some recent synthetic applications of Barton radical methodologies.
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