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Allogeneic Immunotherapy for Malignant Diseases


Allogeneic Immunotherapy for Malignant Diseases Cover


Synopses & Reviews

Publisher Comments:

This important reference offers a comprehensive review of the graft-versus-leukemia (GVL) or -tumor (GVT) effect following allogeneic stem cell transplantation and lymphocyte transfusion, covering a wide range of topics from alloimmune responses to clinical applications of GVL, and providing the basics to understand the mechanisms of the GVL effect while demonstrating methods that use the GVL effect to cure a greater number of cancer patients. Presents preliminary data supporting the idea that allogeneic cell therapy can be used not only for the treatment of leukemia but also for metastatic solid tumors! Written by over 40 world renowned experts in the field and containing more than 1450 references for in-depth exploration of the subject, Allogeneic Immunotherapy for Malignant Diseases 7investigates the capacity of the donor-and the host-to destroy residual leukemia cells by allogeneic immune reaction 7determines how to direct immune reactions against hematopoietic malignancies safely 7reveals which other malignant conditions may be responsive to allogeneic-mediated graft-versus-tumor reactions 7covers the mechanisms that contribute to the development of responses to minor histocompatibility complex (mHC) molecules 7focuses on the biology of effector cells and their role in mediating GVL reactions in chronic myeloid leukemia (CML) 7summarizes the putative impact of human mHag on the GVL effect in bone marrow transplantation (BMT) 7addresses the potential and limitations of oncogene-based immunotherapy 7examines ways to isolate and control the GVL component of allograft immunity 7discusses efforts to develop specific anti-leukemic T-cell immunotherapy 7and more! Attributing thecurative effect of allogeneic stem cell transplantation to the GVL or GVT effect, Allogeneic Immunotherapy for Malignant Diseases is an indispensable reference for hematologists, clinical oncologists, immunologists and researchers in the fields of tumor immunology and cancer immunot

Book News Annotation:

Like others in the series, this monograph dedicated to the editors' patients, illustrates successes resulting from interactions between basic science and clinical research. This volume reflects the growing number of publications on the phenomena of graft-versus-leukemia (GVL) and graft-versus-tumor (GVT) effects in the literature on bone marrow transplantation. Allogenic stem-cell transplantation owes its therapeutic promise to the GVL/GVT effect. In 19 papers, international leaders in relevant fields provide a comprehensive review of the biological basis of GVL/GVT effects (with a brief historical overview), the GVL effect in clinical practice, and modulation and application of GVL effects. Illustrations show mechanisms, outcomes, and the relapse risk of adoptive immunotherapy in animal models and human patients. Barrett heads the Bone Marrow Transplant Unit at the National Institutes of Health, Bethesda, MD, and Jiang is a medical resident at the Bridgeport Hospital, Yale-New Haven Health System, CT.
Annotation c. Book News, Inc., Portland, OR (booknews.com)

Table of Contents

Introduction: the graft-verus-leukemia effect — Pt.1. Biological basis of the GVL effect — The immune response to allontigens — Experimetnal animal models in the study of GVL reactions — Effector cells and mechanisms of the GVL effect — Minor histocompatibility antigens in GVL — Tissue-specific antigens in GVL — Oncoproteins as tumor-specific antigens — Pt.2. The GVL effect in clinical practice — GVL effects in human marrow stem-cell transplants — The GVL effect in donor lymphocyte transfusion — The graft-verus-myeloma effect — the graft-verus-tumor effect — Adoptive allogeneic cell-mediated immunotherapy and nonmyeloablative stem-cell transplantation — Clinical and basic science studies of human umbilical cord blood: implications for the GVL effect following cord blood transplantation — Pt.3. Modulation and application of GVL effects — Separating GVHD and GVL reactions — T-cell subsets and separtion of GVL from GVHD — Molecular immunological modulation of target cells to enhance the GVL effect — Genetic modulation of effector cells to enhance GVL effects — Leukemia-reactive T cells in adoptive immunotherapy for relapsed leukemia after allogeneic transplantation — The BCR-ABL oncoprotein and immunological targeting: vaccination for tumor prevention and therapy.

Product Details

Barrett, John
CRC Press
Barrett, John
Jiang, Yin-Zheng
New York
Transplantation, Homologous.
Hematopoietic Stem Cell Transplantation.
Hematologic Neoplasms
Graft vs Tumor Effect
Health and Medicine-Medical Specialties
Edition Description:
Includes bibliographical references and index.
Basic and clinical oncology ;
Series Volume:
Publication Date:
9.28x6.32x1.00 in. 1.45 lbs.

Related Subjects

Health and Self-Help » Health and Medicine » Medical Specialties
Health and Self-Help » Health and Medicine » Pharmacology

Allogeneic Immunotherapy for Malignant Diseases
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Product details 408 pages Marcel Dekker - English 9780824767815 Reviews:
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