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Mhc Protocols (Methods in Molecular Biology)

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Mhc Protocols (Methods in Molecular Biology) Cover

 

Synopses & Reviews

Publisher Comments:

Many of the genes found in the human major histocompatibility complex (MHC:HLA region) are subject to extreme polymorphism. HLA polymorphism has been used extensively in solid organ and bone marrow transplantation to match donors and recipients. Many MHC genes also have significant disease association and play a pivotal role in the control of immune response. In MHC Protocols, leading experts detail readily reproducible methods for identifying these polymorphisms in the human MHC. Described in step-by-step detail to ensure robust and successful experimental results, these techniques provide DNA-based protocols for the study of polymorphism in HLA class I and II genes and in non-HLA HMC genes associated with human disease (TAP1, TAP2, C2, C4, and TNF-a). The authors also describe methods for accessing HLA sequence data from electronic databases designed to catalog HLA-region genes and their alleles. Each method is written by an investigator who has used the technique extensively and includes troubleshooting tips and notes on pitfalls to avoid. Comprehensive and highly practical, MHC Protocols offers both experienced and novice investigators not only a state-of-the-art overview of this dramatically evolving area of immunology, but also a reliable guide to the identification of MHC gene polymorphisms.

Book News Annotation:

In this book, leading experts in molecular biology research detail reproducible methods for identifying polymorphisms in human MHC. Described in step-by-step detail to ensure robust and successful experimental results, these techniques provide DNA-based protocols for the study of polymorphism in HLA class I and II genes and in non-HLA HMC genes associated with human disease. Contributors also describe methods for accessing HLA sequence data from electronic databases designed to catalog HLA-region genes and their alleles. Each method is detailed by an investigator who has used the technique extensively. Powis is affiliated with the Center for Nephrology at Royal Free and University College Medical School, University College London. Vaughan is affiliated with South Thames Tissue Typing in the Division of Medicine at Guy's Campus, King's College, UK.
Annotation c. Book News, Inc., Portland, OR (booknews.com)

Synopsis:

The major histocompatibility complex is an intensely researched area of immunology. There is evidence that the MHC proteins act as as antigen presenting molecules, and this book provides the latest biochemical and genetic techniques to study these MHC molecules. Its step-by-step, reproducible protocols provide the basic scientist and clinical researcher with a comprehensive set of established protocols for successfully conducting MHC research.

Synopsis:

A collection by leading experts detail of readily reproducible methods for identifying polymorphisms in the human MHC. Described in step-by-step detail to ensure robust and successful experimental results, these techniques provide DNA-based protocols for the study of polymorphism in HLA class I and II genes and in non-HLA HMC genes associated with human disease (TAP1, TAP 2, C2, C4, and TNF- a). The authors also describe methods for accessing HLA sequence data from electronic databases designed to catalog HLA-region genes and their alleles.

Table of Contents

I. Databases HLA Informatics: Accessing HLA Sequences from Sequence Databases James Robinson and Steven G. E. Marsh Accessing HLA Sequencing Data Through the 6ace Database Roger Horton and Stephan Beck II. Polymorphism in Classical and Nonclassical HLA Genes HLA Typing by Restriction Fragment Length Polymorphism Analysis Robert W. Vaughan PCR-Restriction Fragment Length Polymorphism Typing of Class I and II Alleles Robert W. Vaughan PCR-Sequence-Specific Oliogonucleotide Probe Typing for HLA-A, -B, and -DR Derek Middleton and F. Williams HLA-DPA1 and -DPB1 Typing Using the PCR and Nonradioactive Sequence-Specific Oligonucleotide Probes Lori L. Steiner, Priscilla V. Moonsamy, Teodorica L. Bugawan, and Ann B. Begovich PCR-Sequence-Specific Primer Typing of HLA Class I and Class II Alleles Mike Bunce HLA Typing With Reference Strand-Mediated Conformation Analysis J. Rafael Argüello, Martha Pérez-Rodríguez, Andrea Pay, Gaby Fisher, Alasdair McWhinnie, and J. Alejandro Madrigal Sequencing Protocols for Detection of HLA Class I Polymorphism Paul P. J. Dunn, Steven T. Cox, and Ann-Margaret Little HLA-E and HLA-G Typing Jorge Martinez-Laso, Eduardo Gomez-Casado, and Antonio Arnaiz-Villena Typing Alleles of HLA-DM Hélène Teisserenc III. Polymorphism in Non-HLA MHC Genes Typing Alleles of TAP1 and TAP2 Stephen H. Powis Determining Alleles of the C2 Gene by Southern Blotting Zeng-Bian Zhu and John E. Volanakis Complement C4 Protein and DNA Typing Methods Peter M. Schneider and Gottfried Mauff Typing of Tumor Necrosis Factor Alleles Anthony Gerard Wilson Molecular Typing of the MHC Class I Chain-Related Gene Locus R. W. M. Collins, Henry A. F. Stephens, and Robert W. Vaughan IV. Microsatellites HLA Microsatellite Analysis Mary Carrington Index

Product Details

ISBN:
9780896035485
Editor:
Powis, Stephen H.
Editor:
Vaughan, Robert
Editor:
Powis, Stephen H.
Editor:
Vaughan, Robert
Author:
Powis, Stephen H.
Author:
Vaughan, Robert W.
Publisher:
Humana Press
Location:
Totowa, N.J.
Subject:
Immunology
Subject:
Molecular biology
Subject:
Laboratory Medicine
Subject:
Genetic aspects
Subject:
Immunogenetics
Subject:
Genetic polymorphisms.
Subject:
HL-A antigens.
Subject:
Major histocompatibility complex.
Subject:
Polymorphism
Subject:
Health and Medicine-Medical Specialties
Edition Description:
Book
Series:
Methods in Molecular Biology (Hardcover)
Series Volume:
210
Publication Date:
20020931
Binding:
HARDCOVER
Language:
English
Illustrations:
Yes
Pages:
352
Dimensions:
229 x 152 mm 1530 gr

Related Subjects

Health and Self-Help » Health and Medicine » Medical Specialties
Science and Mathematics » Biology » Molecular

Mhc Protocols (Methods in Molecular Biology) New Hardcover
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$180.25 In Stock
Product details 352 pages Humana Press - English 9780896035485 Reviews:
"Synopsis" by , The major histocompatibility complex is an intensely researched area of immunology. There is evidence that the MHC proteins act as as antigen presenting molecules, and this book provides the latest biochemical and genetic techniques to study these MHC molecules. Its step-by-step, reproducible protocols provide the basic scientist and clinical researcher with a comprehensive set of established protocols for successfully conducting MHC research.
"Synopsis" by , A collection by leading experts detail of readily reproducible methods for identifying polymorphisms in the human MHC. Described in step-by-step detail to ensure robust and successful experimental results, these techniques provide DNA-based protocols for the study of polymorphism in HLA class I and II genes and in non-HLA HMC genes associated with human disease (TAP1, TAP 2, C2, C4, and TNF- a). The authors also describe methods for accessing HLA sequence data from electronic databases designed to catalog HLA-region genes and their alleles.
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