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The Family That Couldn't Sleep: A Medical Mystery

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The Family That Couldn't Sleep: A Medical Mystery Cover

 

Synopses & Reviews

Publisher Comments:

For two hundred years a noble Venetian family has suffered from an inherited disease that strikes their members in middle age, stealing their sleep, eating holes in their brains, and ending their lives in a matter of months. In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass.

What these strange conditions–including fatal familial insomnia, kuru, scrapie, and mad cow disease–share is their cause: prions. Prions are ordinary proteins that sometimes go wrong, resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA–and the diseases they bring are now spreading around the world.

In The Family That Couldn’t Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion’s hidden past and deadly future. Through exclusive interviews and original archival research, Max explains this story’s connection to human greed and ambition–from the Prussian chemist Justus von Liebig, who made cattle meatier by feeding them the flesh of other cows, to New Guinean natives whose custom of eating the brains of the dead nearly wiped them out. The biologists who have investigated these afflictions are just as extraordinary–for example, Daniel Carleton Gajdusek, a self-described

“pedagogic pedophiliac pediatrician” who cracked kuru and won the Nobel Prize, and another Nobel winner, Stanley Prusiner, a driven, feared self-promoter who identified the key protein that revolutionized prion study.

With remarkable precision, grace, and sympathy, Max–who himself suffers from an inherited neurological illness–explores maladies that have tormented humanity for centuries and gives reason to hope that someday cures will be found. And he eloquently demonstrates that in our relationship to nature and these ailments, we have been our own worst enemy.

Advance praise

The Family that Couldn’t Sleep is a riveting detective story that plumbs one of the deepest mysteries of biology. The story takes the reader from the torments of an Italian family cursed with sleeplessness to the mad cows of England (and, now, America), following an unlikely trail of misfolded proteins. D. T. Max unfolds his absorbing narrative with rare grace and makes the science sing.” –Michael Pollan, author of The Omnivore’s Dilemma and The Botany of Desire

“Much has been written about prions and Mad Cow Disease–nearly all of it is worthless. Thankfully, from the world of journalism comes D.T. Max to set things right. Throw all those other “Mad Cow” books in the trash: This is the book to read about prions–or whatever you want to call them. It’s a riveting tale, told by someone with a very special understanding, derived in part from his own strange ailment. Find a cozy spot, clear your schedule and dive in.”

– Laurie Garrett, author of Betrayal of Trust and The Coming Plague

“D. T. Max deftly unfolds the mysterious prion in all its villainous guises. Although scientists do not fully understand these proteins–how they replicate and wreak such havoc in their victims’ brains–The Family That Couldn’t Sleep reveals their historical, cultural, and scientific place in our world. Prepare to be enlightened, entertained, and frightened.”

–Katrina Firlik, MD, author of Another Day in the Frontal Lobe

“A great book. D.T. Max has drawn the curtain on a cabinet of folly  and malady that will stagger your imagination.”

– Philip Weiss, author of American Taboo

“D.T. Max has combined the enthralling medical anthropology of Oliver Sacks with the gothic horror of Stephen King to produce a medical detective story that is as intelligent as it is spooky. The villain of The Family That Couldn’t Sleep is the prion, a tiny little protein that causes some of the most terrifying, brain-mangling, creepy diseases known to man. Always fascinating–how could it not be, given that its characters include cannibals, mad cows, madder sheep, a Nobel prize-winning pedophile, and, most poignantly, an Italian family cursed by fatal insomnia?–Max’s book is also a gripping account of scientific discovery, and a heartfelt meditation on what it means to be cursed with an incurable, and brutal, illness.” – David Plotz, author of The Genius Factory

From the Hardcover edition.

Synopsis:

Provides an in-depth study of the science and scientists behind the research into prions, enigmatic brain proteins, and their influence on human life, examining the case of an Italian family victimized for two centuries by a fatal familial insomnia, as well as the link between prions and kuru, Mad Cow disease, Parkinson's, Alzheimer's, and other brain maladies. 50,000 first printing.

Synopsis:

Explores prions, enigmatic brain proteins, and their influence on human life, examining the case of an Italian family victimized for two centuries by a fatal familial insomnia, and the links between prions and various brain maladies.

About the Author

D. T. Max was born and raised in New York City and graduated from Harvard in 1984. He has been an editor at Washington Square Press, Houghton Mifflin, and The New York Observer. For the past eight years, he has reported mostly for The New York Times Magazine. His work has also appeared in the Los Angeles Times, The Wall Street Journal, San Francisco Chronicle, and Chicago Tribune. He lives outside Washington, D.C., with his wife, their two young children, and a rescued beagle named Max.

Table of Contents

Pt. I. Alone in the night. The doctors' dilemma: Venice — Merino mania: England — Pietro: The Veneto — Pt. II. Pushing back the dark. Strong magic: Papua New Guinea — Docta America: Papua New Guinea — Monkey business: Bethesda, Maryland — "Boh!": The Veneto — A wonderful problem for a chemist: San Francisco, late 1970s to early 1980s — Convergence: The Veneto — Pt. III. Nature pushes back. Apocalypse cow: Britain, 1986 — Oinkies: Britain, 1996 — The world according to prions: United States/Britain, 1970s to present day — Did man eat man?: Worldwide, 800,000 B.C.E. — Coming to America?: United States, present day — Pt. IV. Awakenings? For the victims of fatal familial insomnia: The Veneto, present day.

Product Details

ISBN:
9781588365583
Subtitle:
A Medical Mystery
Publisher:
Random House
Author:
D. T. Max
Author:
Daniel T. Max
Author:
Max, Daniel T.
Subject:
Medical-Diseases
Subject:
Medical : Diseases
Subject:
Diseases
Subject:
Sleep disorders
Subject:
Prion diseases
Subject:
Neurology - General
Subject:
History
Subject:
Health and Medicine-History of Medicine
Subject:
main_subject
Subject:
all_subjects
Publication Date:
20060905
Binding:
ELECTRONIC
Language:
English
Pages:
299

Related Subjects

» Health and Self-Help » Health and Medicine » General
» Health and Self-Help » Health and Medicine » History of Medicine
» Health and Self-Help » Health and Medicine » Illnesses
» Health and Self-Help » Health and Medicine » Medical Specialties
» Health and Self-Help » Psychology » Mind and Consciousness

The Family That Couldn't Sleep: A Medical Mystery
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Product details 299 pages Random House - English 9781588365583 Reviews:
"Synopsis" by , Provides an in-depth study of the science and scientists behind the research into prions, enigmatic brain proteins, and their influence on human life, examining the case of an Italian family victimized for two centuries by a fatal familial insomnia, as well as the link between prions and kuru, Mad Cow disease, Parkinson's, Alzheimer's, and other brain maladies. 50,000 first printing.
"Synopsis" by , Explores prions, enigmatic brain proteins, and their influence on human life, examining the case of an Italian family victimized for two centuries by a fatal familial insomnia, and the links between prions and various brain maladies.
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