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Other titles in the Springerbriefs in Applied Sciences and Technology series:

Gigaseal Formation in Patch Clamping: With Applications of Nanotechnology (Springerbriefs in Applied Sciences and Technology)

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Gigaseal Formation in Patch Clamping: With Applications of Nanotechnology (Springerbriefs in Applied Sciences and Technology) Cover

 

Synopses & Reviews

Publisher Comments:

This book presents an investigation of gigaseal formation using micro/nanotechnology. The aims of the book are twofold. First, it explains the mechanisms of gigaseal formation using the latest discoveries. Second, it provides practical techniques for frequent formation of high resistance seals. The formation of a high-resistance electrical seal, also known as a gigaseal, between a cell membrane and a glass micropipette tip is essential in patch-clamp experiments. Even though four decades have passed since the introduction of the patch-clamping technique by Neher and Sakmann, gigaseal formation remains an obstacle in developing the high-throughput ion channel screening systems required by the pharmaceutical industry. Here the authors share their latest methods for achieving gigaseal formation and describe techniques that are highly desirable at both research and industrial levels. Nanotechnology has been found to be a powerful tool for studying and modifying glass micropipettes and in tackling the problem of gigaseal formation.

Table of Contents

Chapter 1 Introduction .-Chapter 2 Development of patch clamping .- Chapter 3 Gigaseal formation .- Chapter 4 Effect of roughness on gigaseal formation .- Chapter 5 Effect of hydrophilicIty on gigaseal formation .- Chapter 6 Effect of tip size on gigaseal formation .- Chapter 7 Study of glass micropipettes from tip formation to characterization .- References.

Product Details

ISBN:
9783642391279
Author:
Malboubi, Majid
Publisher:
Springer
Author:
Jiang, Kyle
Location:
Berlin, Heidelberg
Subject:
Nanotechnology
Subject:
Gigaseal Formation using micropipettes
Subject:
High Resistance Seals
Subject:
High throughput screening
Subject:
Hydrophilicity
Subject:
Patch clamp
Subject:
Patch clamping
Subject:
Surface roughness.
Subject:
Tip Size
Subject:
Nanotechnology and Microengineering
Subject:
Biomedical Engineering
Subject:
Science Reference-Technology
Subject:
Engineering
Subject:
B
Copyright:
Edition Description:
2014
Series:
SpringerBriefs in Applied Sciences and Technology
Publication Date:
20130901
Binding:
TRADE PAPER
Language:
English
Pages:
160
Dimensions:
235 x 155 mm

Related Subjects

Engineering » Engineering » General Engineering
Health and Self-Help » Health and Medicine » Medical Specialties
Reference » Science Reference » Technology

Gigaseal Formation in Patch Clamping: With Applications of Nanotechnology (Springerbriefs in Applied Sciences and Technology) New Trade Paper
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