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Lehninger Principles of Biochemistry

Lehninger Principles of Biochemistry Cover

 

Synopses & Reviews

Publisher Comments:

In the Fifth Edition, authors Dave Nelson and Mike Cox combine the best of the   laboratory and best of the classroom, introducing exciting new developments while communicating basic principles through a variety of new learning tools—from new in-text worked examples and data analysis problems to the breakthrough eBook, which seamlessly integrates the complete text and its media components.

Synopsis:

Authors Dave Nelson and Mike Cox combine the best of the laboratory and best of the classroom, introducing exciting new developments while communicating basic principles of biochemistry.

Table of Contents

1 The Foundations of Biochemistry

1.1 Cellular Foundations

1.2 Chemical Foundations

1.3 Physical Foundations

1.4 Genetic Foundations

1.5 Evolutionary Foundations

Box 1-1 Molecular Weight, Molecular Mass, and Their Correct Units

Box 1-2 Louis Pasteur and Optical Activity: In Vino, Veritas

Box 1-3 Entropy: The Advantages of Being Disorganized

• Now introduces the concepts of proteomes and proteomics

• Updated section on how a new species evolves

• Increased emphasis on the interdependence of life forms in global cycles of energy

 
I STRUCTURE AND CATALYSIS

2 Water

2.1 Weak Interactions in Aqueous Systems

2.2 Ionization of Water, Weak Acids, and Weak Bases

2.3 Buffering against pH Changes in Biological Systems

2.4 Water as a Reactant

2.5 The Fitness of the Aqueous Environment for Living Organisms

Box 2-1 Medicine: On Being Ones Own Rabbit (Dont Try This at Home!)

• Expanded discussion of blood pH buffering by the bicarbonate system,including a new box describing Haldanes use of himself as a guinea pig    in experiments aimed at changing the acidity of blood

• New section on ketoacidosis in diabetes

 
3 Amino Acids, Peptides, and Proteins

3.1 Amino Acids

3.2 Peptides and Proteins

3.3 Working with Proteins

3.4 The Structure of Proteins: Primary Structure

Box 3-1 Methods: Absorption of Light by Molecules: The Lambert-Beer Law

Box 3-2 Methods: Investigating Proteins with Mass Spectrometry

Box 3-3 Medicine: Consensus Sequences and Sequence Logos

• Significant revision to bioinformatics

• More thorough explanation of consensus sequences, including an illustration of common ways to depict consensus sequences

 
4 The Three-Dimensional Structure of Proteins

4.1 Overview of Protein Structure

4.2 Protein Secondary Structure

4.3 Protein Tertiary and Quaternary Structures

4.4 Protein Denaturation and Folding

Box 4-1 Methods: Knowing the Right Hand from the Left

Box 4-2 Permanent Waving Is Biochemical Engineering

Box 4-3 Medicine: Why Sailors, Explorers, and College Students Should  Eat Their Fresh Fruits and Vegetables

Box 4-4 The Protein Data Bank

Box 4-5 Methods: Methods for Determining the Three-Dimensional Structure of a Protein

Box 4-6 Medicine: Death by Misfolding: The Prion Diseases

• New section, Defects in protein folding may be the molecular basis for a wide range of human genetic disorders, discusses a variety of amyloid    diseases

• New section on circular dichroism

 
5 Protein Function

5.1 Reversible Binding of a Protein to a Ligand: Oxygen-Binding Proteins

5.2 Complementary Interactions between Proteins and Ligands: The Immune System and Immunoglobulins

5.3 Protein Interactions Modulated by Chemical Energy: Actin, Myosin, and Molecular Motors

Box 5-1 Medicine: Carbon Monoxide: A Stealthy Killer

6 Enzymes

6.1 An Introduction to Enzymes

6.2 How Enzymes Work

6.3 Enzyme Kinetics as an Approach to Understanding Mechanism

6.4 Examples of Enzymatic Reactions

6.5 Regulatory Enzymes

Box 6-1 Transformations of the Michaelis-Menten Equation: The Double-Reciprocal Plot

Box 6-2 Kinetic Tests for Determining Inhibition Mechanisms

Box 6-3 Evidence for Enzyme-Transition State Complementarity

• More explanatory text added to the mechanisms for the enolase and lysozyme reactions

• New section on pharmaceuticals developed from an understanding of enzyme mechanism, using penicillin and HIV protease inhibitors as examples

 
7 Carbohydrates and Glycobiology

7.1 Monosaccharides and Disaccharides

7.2 Polysaccharides

7.3 Glycoconjugates: Proteoglycans, Glycoproteins, and Glycolipids

7.4 Carbohydrates as Informational Molecules: The Sugar Code

7.5 Working with Carbohydrates

Box 7-1 Medicine: Blood Glucose Measurements in the Diagnosis and Treatment of Diabetes

• New medical box, introduces hemoglobin glycation and AGEs and their role in the pathology of advanced diabetes

• New section on sugar analogs as drugs that target viral neuraminidase

• Introduction to the new field of glycomics, including methods for determining oligosaccharide structure using MALDI-MS

 
8 Nucleotides and Nucleic Acids

8.1 Some Basics

8.2 Nucleic Acid Structure

8.3 Nucleic Acid Chemistry

8.4 Other Functions of Nucleotides

 
9 DNA-Based Information Technologies

9.1 DNA Cloning: The Basics

9.2 From Genes to Genomes

9.3 From Genomes to Proteomes

9.4 Genome Alterations and New Products of Biotechnology

Box 9-1 Medicine: A Potent Weapon in Forensic Medicine

Box 9-2 Medicine: The Human Genome and Human Gene Therapy

• New material on the green fluorescent protein

• Thorough updating of genomics section

 
10 Lipids

10.1 Storage Lipids

10.2 Structural Lipids in Membranes

10.3 Lipids as Signals, Cofactors, and Pigments

10.4 Working with Lipids

Box 10-1 Sperm Whales: Fatheads of the Deep

Box 10-2 Medicine: Abnormal Accumulations of Membrane Lipids: Some Inherited Human Diseases

• New medical section on the role of polyunsaturated fatty acids and trans fatty acids in cardiovascular disease

• New section on lipidomics

• New descriptions of volatile lipids used as signals by plants, and pigments of bird feathers derived from colored lipids in plant foods

11 Biological Membranes and Transport

11.1 The Composition and Architecture of Membranes

11.2 Membrane Dynamics

11.3 Solute Transport across Membranes

Box 11-1 Methods: Atomic Force Microscopy to Visualize Membrane Proteins

Box 11-2 Medicine: Defective Glucose and Water Transport in Two Forms of Diabetes

Box 11-3 Medicine: A Defective Ion Channel in Cystic Fibrosis

• Expanded section on bilayer dynamics covers flippases, floppases, scramblases, and bilayer asymmetry

• Expanded and updated section on lipid rafts and caveolae includes new  material on membrane curvature and the proteins that influence it, and    introduces amphitropic proteins and annular lipids

• New information on the structural basis for voltage gating in a K+ channel

 
12 Biosignaling

12.1 General Features of Signal Transduction

12.2 G Protein-Coupled Receptors and Second Messengers

12.3 Receptor Tyrosine Kinases

12.4 Receptor Guanylyl Cyclases, cGMP, and Protein Kinase G

12.5 Multivalent Scaffold Proteins and Membrane Rafts

12.6 Gated Ion Channels

12.7 Integrins: Bidirectional Cell Adhesion Receptors

12.8 Regulation of Transcription by Steroid Hormones

12.9 Signaling in Microorganisms and Plants

12.10 Sensory Transduction in Vision, Olfaction, and Gustation

12.11 Regulation of the Cell Cycle by Protein Kinases

12.12 Oncogenes, Tumor Suppressor Genes, and Programmed Cell Death

Box 12-1 Methods: Scatchard Analysis Quantifies the Receptor-Ligand Interaction

Box 12-2 Medicine: G Proteins: Binary Switches in Health and Disease

Box 12-3 Methods: FRET: Biochemistry Visualized in a Living Cell

Box 12-4 Medicine: Color Blindness: John Daltons Experiment from the Grave

Box 12-5 Medicine: Development of Protein Kinase Inhibitors for Cancer Treatment

• New Medical section on G protein coupled receptors (GCPRs) discusses the range of diseases for which drugs target GPCRs

• New box on G proteins, proteins that regulate their GTPase activity, and the medical consequences of defective G protein function

• Expanded and integrated treatment of local signaling circuits, including AKAPs and signaling complexes that include protein kinase   A, adenylyl cyclase, and phosphodiesterase, and localized puffs and    waves of Ca2+

• New medical box on the use of protein kinase inhibitors in cancertherapy

 
II BIOENERGETICS AND METABOLISM

13 Bioenergetics and Biochemical Reaction Types

13.1 Bioenergetics and Thermodynamics

13.2 Chemical Logic and Common Biochemical Reactions

13.3 Phosphoryl Group Transfers and ATP

13.4 Biological Oxidation-Reduction Reactions

Box 13-1 Firefly Flashes: Glowing Reports of ATP

• New section, Chemical logic and common biochemical reactions, discusses common biochemical reaction types

 
14 Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway

14.1 Glycolysis

14.2 Feeder Pathways for Glycolysis

14.3 Fates of Pyruvate under Anaerobic Conditions: Fermentation

14.4 Gluconeogenesis

14.5 Pentose Phosphate Pathway of Glucose Oxidation

Box 14-1 Medicine: High Rate of Glycolysis in Tumors Suggests Targets for Chemotherapy and Facilitates Diagnosis

Box 14-2 Athletes, Alligators, and Coelacanths: Glycolysis at Limiting Concentrations of Oxygen

Box 14-3 Ethanol Fermentations: Brewing Beer and Producing Biofuels

Box 14-4 Medicine: Why Pythagoras Wouldnt Eat Falafel: Glucose 6-Phosphate Dehydrogenase Deficiency

• New medical box on glucose uptake deficiency in type 1 diabetes

• New medical box on how the high rate of glycolysis in cancerous tissue aids cancer diagnosis and treatment

 
15 Principles of Metabolic Regulation

15.1 Regulation of Metabolic Pathways

15.2 Analysis of Metabolic Control

15.3 Coordinated Regulation of Glycolysis and Gluconeogenesis

15.4 The Metabolism of Glycogen in Animals

15.5 Coordinated Regulation of Glycogen Synthesis and Breakdown

Box 15-1 Methods: Metabolic Control Analysis: Quantitative Aspects

Box 15-2 Isozymes: Different Proteins That Catalyze the Same Reaction

Box 15-3 Medicine: Genetic Mutations That Lead to Rare Forms of Diabetes

Box 15-4 Carl and Gerty Cori: Pioneers in Glycogen Metabolism and Disease

• New section on emerging role of ribulose 5-phosphate as central regulator of glycolysis and gluconeogenesis

• Expanded discussion of phosphoprotein phosphatases in metabolic regulation

• Expanded coverage of the role of transcriptional regulators in metabolic regulation

• New medical box on mutations that lead to rare forms of diabetes regulation (MODY)

 
16 The Citric Acid Cycle

16.1 Production of Acetyl-CoA (Activated Acetate)

16.2 Reactions of the Citric Acid Cycle

16.3 Regulation of the Citric Acid Cycle

16.4 The Glyoxylate Cycle

Box 16-1 Moonlighting Enzymes: Proteins with More Than One Job

Box 16-2 Synthases and Synthetases; Ligases and Lyases; Kinases,Phosphatases, and Phosphorylases: Yes, the Names Are Confusing!

Box 16-3 Citrate: A Symmetric Molecule That Reacts Asymmetrically

Box 16-4 Citrate Synthase, Soda Pop, and the World Food Supply

• New box on effect of diabetes on the citric acid cycle and ketone body formation

• Expanded discussion of substrate channeling

• New section on mutations in citric acid cycle that lead to cancer

• New box on moonlighting enzymes

 
17 Fatty Acid Catabolism

17.1 Digestion, Mobilization, and Transport of Fats

17.2 Oxidation of Fatty Acids

17.3 Ketone Bodies

Box 17-1 Fat Bears Carry Out b Oxidation in Their Sleep

Box 17-2 Coenzyme B12: A Radical Solution to a Perplexing Problem

• New section on the role of transcription factors (PPARs) in regulation of lipid catabolism

 
18 Amino Acid Oxidation and the Production of Urea

18.1 Metabolic Fates of Amino Groups

18.2 Nitrogen Excretion and the Urea Cycle

18.3 Pathways of Amino Acid Degradation

Box 18-1 Medicine: Assays for Tissue Damage

Box 18-2 Medicine: Scientific Sleuths Solve a Murder Mystery

• New section on pernicious anemia and associated problems in strict vegetarians.

19 Oxidative Phosphorylation and Photophosphorylation

Oxidative Phosphorylation

19.1 Electron-Transfer Reactions in Mitochondria

19.2 ATP Synthesis

19.3 Regulation of Oxidative Phosphorylation

19.4 Mitochondria in Thermogenesis, Steroid Synthesis, and Apoptosis

19.5 Mitochondrial Genes: Their Origin and the Effects of Mutations

Photosynthesis: Harvesting Light Energy

19.6 General Features of Photophosphorylation

19.7 Light Absorption

19.8 The Central Photochemical Event: Light-Driven Electron Flow

19.9 ATP Synthesis by Photophosphorylation

19.10 The Evolution of Oxygenic Photosynthesis

Box 19-1 Hot, Stinking Plants and Alternative Respiratory Pathways

• Updated discussion of the structure of the electron transfer complexes of mitochondria and chloroplasts, and of the Fo complex

• Updated description of the water-splitting complexs structure in chloroplasts

• Expanded description of mitochondrial diseases and mitochondrial role in diabetes 

 
20 Carbohydrate Biosynthesis in Plants and Bacteria

20.1 Photosynthetic Carbohydrate Synthesis

20.2 Photorespiration and the C4 and CAM Pathways

20.3 Biosynthesis of Starch and Sucrose

20.4 Synthesis of Cell Wall Polysaccharides: Plant Cellulose and Bacterial Peptidoglycan

20.5 Integration of Carbohydrate Metabolism in the Plant Cell

21 Lipid Biosynthesis

21.1 Biosynthesis of Fatty Acids and Eicosanoids

21.2 Biosynthesis of Triacylglycerols

21.3 Biosynthesis of Membrane Phospholipids

21.4 Biosynthesis of Cholesterol, Steroids, and Isoprenoids

Box 21-1 Mixed-Function Oxidases, Oxygenases, and Cytochrome P-450

• Revised and updated section on fatty acid synthase includes new structural information on FAS I

• Updated information on cyclooxygenase inhibitors (pain relievers Vioxx, Celebrex, Bextra)

• New information on HMG-CoA reductase and new medical box on statins

 
22 Biosynthesis of Amino Acids, Nucleotides, and Related Molecules

22.1 Overview of Nitrogen Metabolism

22.2 Biosynthesis of Amino Acids

22.3 Molecules Derived from Amino Acids

22.4 Biosynthesis and Degradation of Nucleotides

Box 22-1 Unusual lifestyles of the obscure but abundant

Box 22-2 Medicine: On Kings and Vampires

Box 22-3 Medicine: Curing African Sleeping Sickness with a Biochemical Trojan Horse

• Updated coverage of nitrogen cycle section includes a new box on anammox bacteria

• New information on therapy for acute lymphoblastic leukemia

• New information on folic acid deficiency

 
23 Hormonal Regulation and Integration of Mammalian Metabolism

23.1 Hormones: Diverse Structures for Diverse Functions

23.2 Tissue-Specific Metabolism: The Division of Labor

23.3 Hormonal Regulation of Fuel Metabolism

23.4 Obesity and the Regulation of Body Mass

23.5 Obesity, the Metabolic Syndrome, and Type 2 Diabetes

Box 23-1 Medicine: How Is a Hormone Discovered? The Arduous Path to Purified Insulin

• Expanded coverage and updating of the biochemical connections between obesity, metabolic syndrome, and type 2 diabetes

• Updated discussion of the integration of fuel metabolism in fed and starved states in diabetes

 
III INFORMATION PATHWAYS

24 Genes and Chromosomes

24.1 Chromosomal Elements

24.2 DNA Supercoiling

24.3 The Structure of Chromosomes

Box 24-1 Medicine: Curing Disease by Inhibiting Topoisomerases

Box 24-2 Medicine: Epigenetics, Nucleosome Structure, and Histone Variants

• New material on histone modification, histone variants, and nucleosome deposition

• New medical box on the use of topoisomerase inhibitors in the treatment of bacterial infections and cancer, includes material on ciprofloxacin (the    antibiotic effective for anthrax)

• New box on the role of histone modification and nucleosome deposition in the transmission of epigenetic information in heredity

 
25 DNA Metabolism

25.1 DNA Replication

25.2 DNA Repair

25.3 DNA Recombination

Box 25-1 Medicine: DNA Repair and Cancer

• New information on the initiation of replication and the dynamics at the replication fork, introducing AAA+ ATPases and their functions in replication and other aspects of DNA metabolism

 
26 RNA Metabolism

26.1 DNA-Dependent Synthesis of RNA

26.2 RNA Processing

26.3 RNA-Dependent Synthesis of RNA and DNA

Box 26-1 Methods: RNA Polymerase Leaves Its Footprint on a Promoter

Box 26-2 Fighting AIDS with Inhibitors of HIV Reverse Transcriptase

Box 26-3 Methods: The SELEX Method for Generating RNA Polymers with New Functions

Box 26-4 An Expanding RNA Universe Filled with TUF RNAs

• New section on the expanding roles of RNA in cells

 
27 Protein Metabolism

27.1 The Genetic Code

27.2 Protein Synthesis

27.3 Protein Targeting and Degradation

Box 27-1 Exceptions That Prove the Rule: Natural Variations in the Genetic Code

Box 27-2 From an RNA World to a Protein World

Box 27-3 Natural and Unnatural Expansion of the Genetic Code

Box 27-4 Induced Variation in the Genetic Code: Nonsense Suppression

• Expanded section on protein synthesis coupled to the advances in ribosome structure

• New information on the roles of RNA in protein biosynthesis

 
28 Regulation of Gene Expression

28.1 Principles of Gene Regulation

28.2 Regulation of Gene Expression in Bacteria

28.3 Regulation of Gene Expression in Eukaryotes

Box 28-1 Of Fins, Wings, Beaks, and Things

• New information about roles of RNA in gene regulation

• New box on the connections between evolution and development

Appendix A Common Abbreviations in the Biochemical Research Literature

Appendix B Abbreviated Solutions to Problems

Glossary

Credits

Index

Product Details

ISBN:
9780716771081
Publisher:
W.H. Freeman & Company
Subject:
Chemistry - General
Author:
Cox, Michael M.
Author:
Cram101 Textbook Reviews
Author:
Nelson, David L.
Author:
Lehninger, Albert
Author:
Cox, Michael
Subject:
Biochemistry
Subject:
Life Sciences - Biochemistry
Subject:
Chemistry-Biochemistry
Subject:
Education-General
Edition Description:
Fifth Edition
Series:
Lehninger Principles of Biochemistry
Publication Date:
20080231
Binding:
HARDCOVER
Language:
English
Illustrations:
Y
Pages:
1100
Dimensions:
11.13 x 9.13 in

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Lehninger Principles of Biochemistry
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Product details 1100 pages W.H. Freeman & Company - English 9780716771081 Reviews:
"Synopsis" by , Authors Dave Nelson and Mike Cox combine the best of the laboratory and best of the classroom, introducing exciting new developments while communicating basic principles of biochemistry.
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