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Original Essays | September 15, 2014

Lois Leveen: IMG Forsooth Me Not: Shakespeare, Juliet, Her Nurse, and a Novel



There's this writer, William Shakespeare. Perhaps you've heard of him. He wrote this play, Romeo and Juliet. Maybe you've heard of it as well. It's... Continue »
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    Juliet's Nurse

    Lois Leveen 9781476757445

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2 Hawthorne Psychology- Cognitive Science

Connectome: How the Brain's Wiring Makes Us Who We Are

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Connectome: How the Brain's Wiring Makes Us Who We Are Cover

ISBN13: 9780547508184
ISBN10: 0547508182
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Excerpt

Introduction

No road, no trail can penetrate this forest. The long and delicate branches of its trees lie everywhere, choking space with their exuberant growth. No sunbeam can fly a path tortuous enough to navigate the narrow spaces between these entangled branches. All the trees of this dark forest grew from 100 billion seeds planted together. And, all in one day, every tree is destined to die.

   This forest is majestic, but also comic and even tragic. It is all of these things. Indeed, sometimes I think it is everything. Every novel and every symphony, every cruel murder and every act of mercy, every love affair and every quarrel, every joke and every sorrow — all these things come from the forest.

   You may be surprised to hear that it fits in a container less than one foot in diameter. And that there are seven billion on this earth. You happen to be the caretaker of one, the forest that lives inside your skull. The trees of which I speak are those special cells called neurons. The mission of neuroscience is to explore their enchanted branches — to tame the jungle of the mind (see Figure 1).

   Neuroscientists have eavesdropped on its sounds, the electrical signals inside the brain. They have revealed its fantastic shapes with meticulous drawings and photos of neurons. Their discoveries are amazing, but from just a few scattered trees, can we hope to comprehend the totality of the forest?

   In the seventeenth century, the French philosopher and mathematician Blaise Pascal wrote about the vastness of the universe:

          Let man contemplate Nature entire in her full and lofty majesty; let him put far from his sight the

          lowly objects that surround him; let him regard that blazing light, placed like an eternal lamp to 

          illuminate the world; let the earth appear to him but a point within the vast circuit which that star

          describes; and let him marvel that this immense circumference is itself but a speck from the 

          viewpoint of the stars that move in the firmament.

Shocked and humbled by these thoughts, he confessed that he was terrified by “the eternal silence of these infinite spaces.” Pascal meditated upon outer space, but we need only turn our thoughts inward to feel his dread. Inside every one of our skulls lies an organ so vast in its complexity that it might as well be infinite.

   As a neuroscientist myself, I have come to know firsthand Pascals feeling of dread. I have also experienced embarrassment. Sometimes I speak to the public about the state of our field. After one such talk, I was pummeled with questions. What causes depression and schizophrenia? What is special about the brain of an Einstein or a Beethoven? How can my child learn to read better? As I failed to give satisfying answers, I could see faces fall. In my shame I finally apologized to the audience. “Im sorry,” I said. “You thought Im a professor because I know the answers. Actually Im a professor because I know how much I dont know.”

   Studying an object as complex as the brain may seem almost futile. The brains billions of neurons resemble trees of many species and come in many fantastic shapes. Only the most determined explorers can hope to capture a glimpse of this forests interior, and even they see little, and see it poorly. Its no wonder that the brain remains an enigma. My audience was curious about brains that malfunction or excel, but even the humdrum lacks explanation. Every day we recall the past, perceive the present, and imagine the future. How do our brains accomplish these feats? Its safe to say that nobody really

knows.

   Daunted by the brains complexity, many neuroscientists have chosen to study animals with drastically fewer neurons than humans. The worm shown in Figure 2 lacks what wed call a brain. Its neurons are scattered throughout its body rather than centralized in a single organ. Together they form a nervous system containing a mere 300 neurons. That sounds manageable. Ill wager that even Pascal, with his depressive tendencies, would not have dreaded the forest of C. elegans. (Thats the scientific name for the one-millimeter-long worm.)

   Every neuron in this worm has been given a unique name and has a characteristic location and shape. Worms are like precision machines mass-produced in a factory: Each one has a nervous system built from the same set of parts, and the parts are always arranged in the same way.

   Whats more, this standardized nervous system has been mapped completely. The result — see Figure 3 — is something like the flight maps we see in the back pages of airline magazines. The four-letter name of each neuron is like the three-letter code for each of the worlds airports. The lines represent connections between neurons, just as lines on a flight map represent routes between cities. We say that two neurons are “connected” if there is a small junction, called a synapse, at a point where the neurons touch. Through the synapse one neuron sends messages to the other.

   Engineers know that a radio is constructed by wiring together electronic components like resistors, capacitors, and transistors. A nervous system is likewise an assembly of neurons, “wired” together by their slender branches. Thats why the map shown in Figure 3 was originally called a wiring diagram. More recently, a new term has been introduced — connectome. This word invokes not electrical engineering but the field of genomics. You have probably heard that DNA is a long molecule resembling a chain. The individual links of the chain are small molecules called nucleotides, denoted by the letters A, C, G, and T. Your genome is the entire sequence of nucleotides in your DNA, or equivalently a long string of letters drawn from this four-letter alphabet. Figure 4 shows an excerpt from the three billion letters, which would be a million pages long if printed as a

book.

   In the same way, a connectome is the totality of connections between the neurons in a nervous system. The term, like genome, implies completeness. A connectome is not one connection, or even many. It is all of them. In principle, your brain can also be summarized by a diagram that is like the worms, though much more complex. Would your connectome reveal anything interesting about you?

   The first thing it would reveal is that you are unique. You know this, of course, but it has been surprisingly difficult to pinpoint where, precisely, your uniqueness resides. Your connectome and mine are very different. They are not standardized like those of worms. Thats consistent with the idea that every human is unique in a way that a worm is not (no offense intended to worms!).

   Differences fascinate us. When we ask how the brain works, what mostly interests us is why the brains of people work so differently. Why cant I be more outgoing, like my extroverted friend? Why does my son find reading more difficult than his classmates do? Why is my teenage cousin starting to hear imaginary voices? Why is my mother losing her memory? Why cant my spouse (or I) be more compassionate and understanding?

   This book proposes a simple theory: Minds differ because connectomes differ. The theory is implicit in newspaper headlines like “Autistic Brains Are Wired Differently.” Personality and IQ might also be explained by connectomes. Perhaps even your memories, the most idiosyncratic aspect of your personal identity, could be encoded in your connectome.

   Although this theory has been around a long time, neuroscientists still dont know whether its true. But clearly the implications are enormous. If its true, then curing mental disorders is ultimately about repairing connectomes. In fact, any kind of personal change — educating yourself, drinking less, saving your marriage — is about changing your connectome.

   But lets consider an alternative theory: Minds differ because genomes differ. In effect, we are who we are because of our genes. The new age of the personal genome is dawning. Soon we will be able to find our own DNA sequences quickly and cheaply. We know that genes play a role in mental disorders and contribute to normal variation in personality and IQ. Why study connectomes if genomics is already so powerful?

   The reason is simple: Genes alone cannot explain how your brain got to be the way it is. As you lay nestled in your mothers womb, you already possessed your genome but not yet the memory of your first kiss. Your memories were acquired during your lifetime, not before. Some of you can play the piano; some can ride a bicycle. These are learned abilities rather than instincts programmed by the genes.

   Unlike your genome, which is fixed from the moment of conception, your connectome changes throughout life. Neuroscientists have already identified the basic kinds of change. Neurons adjust, or “reweight,” their connections by strengthening or weakening them. Neurons reconnect by creating and eliminating synapses, and they rewire by growing and retracting branches. Finally, entirely new neurons are created and eliminated, through regeneration.

   We dont know exactly how life events — your parents divorce, your fabulous year abroad — change your connectome. But there is good evidence that all four Rs — reweighting, reconnection, rewiring, and regeneration — are affected by your experiences. At the same time, the four Rs are also guided by genes. Minds are indeed influenced by genes, especially when the brain is “wiring” itself up during infancy and childhood.

   Both genes and experiences have shaped your connectome. We must consider both historical influences if we want to explain how your brain got to be the way it is. The connectome theory of mental differences is compatible with the genetic theory, but it is far richer and more complex because it includes the effects of living in the world. The connectome theory is also less deterministic. There is reason to believe that we shape our own connectomes by the actions we take, even by the things we think. Brain wiring may make us who we are, but we play an important role in wiring up our brains.

   To restate the theory more simply:

   You are more than your genes. You are your connectome.

 

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sheila_clover, February 7, 2012 (view all comments by sheila_clover)
What makes us who we are? Of course, our genetic map, referred to as the genome, stores our hereditary information, but surely this is not all that there is to us. In fact, only a moment of reflection will help you to understand the impossibility of this. What about the memory of your first love? Is that in your genome? And think for a moment about your failures and the lessons you have learned as a result. That information is not genetic, right? The truth of the matter is simply that we have yet to understand the complexities of our development as whole human creatures and the qualities that make each of us unique. These are still mysteries we have yet to fully comprehend. But an ambitious and capable professor at MIT is working to change all of that. Sebastian Seung, a professor of computational neuroscience, seeks to understand the complex relationship between neuronal connections and what we are as real people. The science may seem a little “mind-boggling,” but Seung, using clear language and his knack for story-telling, will help ordinary people to understand the vast network of neurons and their impact upon the development of what might be referred to as our human core, our hopes and dreams, our passions and fears. The implications are astounding. Seung, along with the help of colleagues, wants to map the “connectome,” a relatively new term used to refer to the intricate system of neuronal connections just mentioned. In Connectome: How the Brain's Wiring Makes Us Who We Are, he provides an illustration of how these connections between neurons relate to the paths we take as people. More importantly, it may provide clues to the causes of serious conditions that in many ways hinder the functioning of people in society, like schizophrenia and bipolar disorder. Seung, who has received numerous accolades in a variety of contexts, is at the forefront of a field that promises to achieve many breakthroughs with regard to our understanding of human nature and the reasons behind certain behaviors. Connectome is extremely important for any reader interested in brain science or recent discoveries in neuroscience, but it should also be well-received by readers who generally wish to know more about discoveries involving what shapes us as unique human beings.
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Product Details

ISBN:
9780547508184
Author:
Seung, Sebastian
Publisher:
Houghton Mifflin
Subject:
General-General
Copyright:
Edition Description:
Trade Cloth
Publication Date:
20120231
Binding:
HARDCOVER
Language:
English
Illustrations:
66 illustrations
Pages:
384
Dimensions:
9 x 6 in 1 lb

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Related Subjects

Featured Titles » Science
Health and Self-Help » Psychology » Cognitive Science
Health and Self-Help » Psychology » Mind and Consciousness
History and Social Science » Current Affairs » General
Science and Mathematics » Biology » Neurobiology

Connectome: How the Brain's Wiring Makes Us Who We Are Used Hardcover
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Product details 384 pages Houghton Mifflin Harcourt (HMH) - English 9780547508184 Reviews:
"Review" by , "A landmark work, gorgeously written. No other researcher has traveled as deeply into the brain forest and emerged to share its secrets."
"Review" by , "Connectomics is emerging as a crucial and exhilarating field of study. Sebastian Seung takes you by the hand and shows you why. Connectome is a page-turner — a book that should be read by anyone who lays claim to be thinking about the nature of life."
"Review" by , "Sebastian Seung scales the heights of neuroscience and casts his brilliant eye around, describing the landscape of its past and boldly envisioning a future when we may understand our own brains and thus ourselves."
"Review" by , "Sebastian Seung can do it all. He's widely recognized as a superb physicist, a whiz with computers, and a path-breaking neuroscientist. Connectome shows that he's also a terrific writer, as inspiring as he is clear and good-humored."
"Review" by , "The best lay book on brain science I've ever read." Wall Street Journal by Daniel Levitin, Professor, McGill University; author of This Is Your Brain on Music and The World in Six Songs.
"Review" by , "This is complicated stuff, and it is a testament to Dr. Seung's remarkable clarity of exposition that the reader is swept along with his enthusiasm, as he moves from the basics of neuroscience out to the farthest regions of the hypothetical, sketching out a spectacularly illustrated giant map of the universe of man."
"Review" by , "[A] bracing, mind-expanding report from neurosciences razor edge. Accessible, witty, [e]minently logical and at times poetic, Connectome establishes Seung as an important new researcher, philosopher and popularizer of brain science. It puts him on par with cosmology's Brian Greene and the late Carl Sagan."
"Review" by , "Seung argues intelligently and powerfully that the self lies in the totality of the brains wiring." Christof Koch, Professor, California Institute of Technology; Chief Scientific Officer, Allen Institute for Brain Science; author of Quest for Consciousness and Consciousness: Confessions of a Romantic Reductionist
"Review" by , "With the first-person flavour of James Watsons Double Helix — an account of how DNAs structure was discovered — Connectome gives a sense of the excitement on the cutting edge of neuroscience."
"Review" by , "An elegant primer on what's known about how the brain is organized and how it grows, wires its neurons, perceives its environment, modifies or repairs itself, and stores information. Seung is a clear, lively writer who chooses vivid examples."
"Review" by , "In Connectome, Sebastian Seung reminds us that the human brain has contemplated itself for centuries. This is an important book, full of refreshingly new science and engaging history, about the essential quest to understand ourselves."
"Synopsis" by ,
The audacious effort to map the brain—and along with it our mental afflictions, from autism to schizophrenia—by a rising star in neuroscience.
"Synopsis" by , YOU ARE MORE THAN YOUR GENES. YOU ARE YOUR CONNECTOME.

The bold and thrilling quest to finally understand the brain — and along with it our mental afflictions, from depression to autism — by a rising star in neuroscience.

Sebastian Seung, a dynamic young professor at MIT, is at the forefront of a revolution in neuroscience. He believes that our identity lies not in our genes, but in the connections between our brain cells — our own particular wiring. Seung and a dedicated group of researchers are leading the effort to map these connections, neuron by neuron, synapse by synapse. It is a monumental effort — the scientific equivalent of climbing Mount Everest — but if they succeed, they will uncover the basis of personality, identity, intelligence, memory, and perhaps disorders such as autism and schizophrenia. Seung explains how this new map of a human "connectome" might even enable us to "upload" our brains into a computer, making us effectively immortal.

Connectome is a mind-bending adventure story, told with great passion and authority. It presents a daring scientific and technological vision for at last understanding what makes us who we are, both as individuals and as a species.

www.connectomethebook.com

"Synopsis" by ,
“This is complicated stuff, and it is a testament to Dr. Seung’s remarkable clarity of exposition that the reader is swept along with his enthusiasm, as he moves from the basics of neuroscience out to the farthest regions of the hypothetical, sketching out a spectacularly illustrated giant map of the universe of man.”—Abigail Zuger, M.D., New York Times

Every person is unique, but science has struggled to pinpoint where, precisely, that uniqueness resides. Our genome may determine our eye color and even aspects of our character. But our friendships, failures, and passions also shape who we are. The question is: how?

Sebastian Seung is at the forefront of a revolution in neuroscience. He believes that our identity lies not in our genes, but in the connections between our brain cells—our particular wiring. Seung and a dedicated group of researchers are leading the effort to map these connections, neuron by neuron, synapse by synapse. It’s a monumental effort, but if they succeed, they will uncover the basis of personality, identity, intelligence, memory, and perhaps disorders such as autism and schizophrenia.

Connectome is a mind-bending adventure story that presents a daring scientific and technological vision for understanding what makes us who we are, both as individuals and as a species.

“Accessible, witty, imminently logical and at times poetic, Connectome establishes Seung as an important new researcher, philosopher and popularizer of brain science. It puts him on par with cosmology’s Brian Greene and the late Carl Sagan.”—Cleveland Plain Dealer

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