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How the Cows Turned Mad: Unlocking the Mysteries of Mad Cow Disease

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How the Cows Turned Mad: Unlocking the Mysteries of Mad Cow Disease Cover

 

Synopses & Reviews

Publisher Comments:

Fear of mad cow disease, a lethal illness transmitted from infected beef to humans, has spread from Europe to the United States and around the world. Originally published to much acclaim in France, this scientific thriller, available in English for the first time and updated with a new chapter on developments in 2001, tells of the hunt for the cause of an enigmatic class of fatal brain infections, of which mad cow disease is the latest incarnation. In gripping, nontechnical prose, Maxime Schwartz details the deadly manifestations of these diseases throughout history, describes the major players and events that led to discoveries about their true nature, and outlines our current state of knowledge. The book concludes by addressing the question we all want answered: should we be afraid?

The story begins in the eighteenth century with the identification of a mysterious illness called scrapie that was killing British sheep. It was not until the 1960s that scientists understood that several animal and human diseases, including scrapie, were identical, and together identified them as transmissible spongiform encephalopathy (TSE). The various guises assumed throughout history by TSE include an illness called kuru in a cannibalistic tribe in Papua New Guinea, an infectious disease that killed a group of children who had been treated for growth hormone deficiencies, and mad cow disease. Revealing the fascinating process of scientific discovery that led to our knowledge of TSE, Schwartz relates pivotal events in the history of biology, including the Pasteurian revolution, the birth of genetics, the emergence of molecular biology, and the latest developments in biotechnology. He also explains the Nobel Prize–winning prion hypothesis, which has rewritten the rules of biological heredity and is a key link between the distinctive diseases of TSE.

Up-to-date, informative, and thoroughly captivating, How the Cows Turned Mad tells the story of a disease that continues to elude on many levels. Yet science has come far in understanding its origins, incubation, and transmission. This authoritative book is a stunning case history that illuminates the remarkable progression of science.

Book News Annotation:

The paperback edition of the 2003 translation contains a new foreword by Marion Nestle (Safe Food) that brings Schwartz's fascinating and troubling story up-to-date with recent scares in the US. Writing for the popular reader, Schwartz (molecular biology, Institut Pasteur, Paris, France) describes the increase in scientific understanding of the animal-transmitted diseases which cause spongiform encephalopathy from the 18th century to current genetic research of prions. He simultaneously relates the history of the spread of the disease in Europe (through 2000). The French edition was published in 2001 by Éditions Odile Jacob.
Annotation ©2004 Book News, Inc., Portland, OR (booknews.com)

Synopsis:

"Schwartz's fully engrossing, two-century-plus detective story provides a thoroughgoing history of the discovery of 'mad cow' and related diseases that also illuminates the ways in which science works. I could not put this book down."—Jon Beckwith, author of Making Genes, Making Waves: A Social Activist in Science

"Rarely have I read a book as scary, interesting, informative and enjoyable."—John E. Talbott, University of California, Santa Barbara

Praise for the French edition:

"Maxime Schwartz's book . . . constitutes an ode to science, to its rigor, to its perseverance, but also, as we shall see, to its modesty. How the Cows Turned Mad is a gothic historical novel: its author, molecular biologist and former director of the Pasteur Institute, leads us along a thread that unravels over almost three centuries, from Louis XV to Tony Blair."—Le Figaro

"But above all, and this is indeed remarkable in a work which treats such a scientific subject, How the Cows Turned Mad is not a scientific treatise for scientists, but rather a book. And as such, it reads easily and pleasurably."—Le Généraliste

"How the Cows Turned Mad: that's the title of this book, almost a detective novel, just published by the molecular biologist Maxime Schwartz. An indispensable tool that allows us to sort through the truths and untruths and finally assess the situation."—Panorama du médecin

About the Author

Maxime Schwartz, a molecular biologist, is Professor at the Institut Pasteur in Paris, which he headed from 1988 to 1999. He is also Director of Research at the Centre national de la recherche scientifique (CNRS) and is currently serving as Director of Laboratories of the French agency for food safety (AFSSA). He is the author of many scientific papers and Pasteur, des microbes au vaccin (1999, with Annick Perrot).

Table of Contents

Prologue

1: The Sheep Are Strangely Dizzy

2: Molecules and Microbes

3: Mad Dogs and Earthworms

4: Scrapie under the Microscope

5: Creutzfeldt, Jakob, and Others

6: Scrapie Is Inoculable

7: And Goats, and Mice

8: Scrapie Is Contagious

9: Kuru and the Fore People of Papua New Guinea

10: The Wall Comes Down

11: From Pearl Necklace to Double Helix

12: The Phantom Virus

13: A Tragedy in the Making

14: One Case per Million

15: Prions

16: April 1985

17: The "Kiss of Death"

18: The Return of the Spontaneists

19: To Grow—and to Die

20: Lessons Learned

21: Have the Cows Gone Mad?

22: From Cows to Humans

23: From Cows to Sheep? From Humans to Humans?

24: The Secret in the Closet

25: Unmasking "The Disease"

26: Have We Conquered "The Disease"?

27: 2001

Epilogue

Notes

Bibliography

Chronology

Acknowledgments

Index

Product Details

ISBN:
9780520243378
Author:
Schwartz, Maxime
Publisher:
University of California Press
Translator:
Schneider, Edward
Foreword by:
Nestle, Marion
Foreword:
Nestle, Marion
Author:
Nestle, Marion
Author:
Schneider, Edward
Location:
Berkeley
Subject:
History
Subject:
Prion diseases
Subject:
Neurology - General
Subject:
Life Sciences - Zoology - Mammals
Subject:
Prion diseases - History
Subject:
Diseases
Subject:
Health and Medicine-History of Medicine
Copyright:
Edition Description:
Trade paper
Series Volume:
no. 184
Publication Date:
20040931
Binding:
TRADE PAPER
Language:
English
Pages:
256
Dimensions:
9 x 6 x 0.63 in 13 oz

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Related Subjects

Health and Self-Help » Health and Medicine » History of Medicine
Health and Self-Help » Health and Medicine » Medical Specialties
History and Social Science » World History » General
Reference » Science Reference » General
Science and Mathematics » Agriculture » Beef and Dairy
Science and Mathematics » Agriculture » General
Science and Mathematics » Agriculture » Veterinary Medicine
Science and Mathematics » Biology » Zoology » Mammals
Science and Mathematics » Nature Studies » World Wildlife

How the Cows Turned Mad: Unlocking the Mysteries of Mad Cow Disease Used Trade Paper
0 stars - 0 reviews
$9.50 In Stock
Product details 256 pages University of California Press - English 9780520243378 Reviews:
"Synopsis" by ,
"Schwartz's fully engrossing, two-century-plus detective story provides a thoroughgoing history of the discovery of 'mad cow' and related diseases that also illuminates the ways in which science works. I could not put this book down."—Jon Beckwith, author of Making Genes, Making Waves: A Social Activist in Science

"Rarely have I read a book as scary, interesting, informative and enjoyable."—John E. Talbott, University of California, Santa Barbara

Praise for the French edition:

"Maxime Schwartz's book . . . constitutes an ode to science, to its rigor, to its perseverance, but also, as we shall see, to its modesty. How the Cows Turned Mad is a gothic historical novel: its author, molecular biologist and former director of the Pasteur Institute, leads us along a thread that unravels over almost three centuries, from Louis XV to Tony Blair."—Le Figaro

"But above all, and this is indeed remarkable in a work which treats such a scientific subject, How the Cows Turned Mad is not a scientific treatise for scientists, but rather a book. And as such, it reads easily and pleasurably."—Le Généraliste

"How the Cows Turned Mad: that's the title of this book, almost a detective novel, just published by the molecular biologist Maxime Schwartz. An indispensable tool that allows us to sort through the truths and untruths and finally assess the situation."—Panorama du médecin

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