Synopses & Reviews
Arthritis Research: Methods and Protocols is a compendium of data pertinent to the methods and protocols that have contributed to recent advances in molecular medicine in general, but to the molecular basis of rheumatic disease in particular. These volumes details novel technologies, some of which are still evolving and whose impacts are yet to be determined. Leaders in the field contribute to cover such exciting and cutting edge topics as imaging and immunohistochemistry, analysis of cartilage and bone catabolism, immunobiology, and cell trafficking.
In Volume 1, authors discuss synovial joint morphology, histopathology, and immunohistochemistry, cartilage matrix and bone biology, and cell trafficking, migration and invasion. Volume 2 is broken up into sections that cover immunobiology and T cells, animal models of arthritis, and applications of new technologies, such as Differential Display Reverse Transcription-Polymerase Chain Reaction (DDRT-PCR), to define novel therapeutic targets. Both volumes combine to produce a concise set of protocols condensing decades of experience and expertise.
Arthritis Research: Methods and Protocols will be a valuable tool for basic research investigators, clinician scientists, pathologists, immunologists, and biochemists looking to stay current in their fields.
From the reviews: "This volume excels in the presentation of basic, fundamental techniques requisite in the anaylsis of arthritic disease. Especially well done are the immunobiology and animal model sections." -Doody's Book Review, Weighted Numerical Score:96 - 4 Stars "This multiauthored ... compendium of arthritis research methods and protocols provides pertinent practical information for the bench researcher as well as for the interested clinician. ... It is a worthwhile reference to have in the research laboratory ... . I enthusiastically recommend ... and believe this publication would have broad appeal to the rheumatologic community and to those in related specialties. ... I congratulate the authors on developing an excellent compendium of arthritis research ... ." (Robert J. Quinet, JAMA, April, 2008)
Arthritis Research: Methods and Protocols Volumes 1 & 2 covers the methods and protocols that have contributed to advances in treating rheumatic diseases. They combine to form a concise set of protocols condensing decades of experience and expertise. These volumes are an essential collection for basic scientists, clinician scientists and clinicians alike.
Here is a compendium of data pertinent to the methods and protocols that have contributed to both recent advances in molecular medicine in general as well as to molecular basis of rheumatic disease in particular. This two-volume work collects the contributions of leaders in the field who cover such exciting and cutting edge topics as imaging and immunohistochemistry, analysis of cartilage and bone catabolism, immunobiology, and cell trafficking.
Table of Contents
Arthritis: Methods and Protocols, Volume II Andrew P. Cope, PhD I. Immunobiology 1. Phenotypic Analysis of B Cells and Plasma Cells Henrik E. Mei, Taketoshi Yoshida, Gwendowlin Muehlinghaus, Falk Hiepe Thomas Dorner, Andreas Radbruch and Bimba F. Hoyer 2. Detection of Antigen Specific B Cells in Tissues Marie Wahren-Herlenius and Stina Salomonsson 3. Single Cell Analysis of Synovial Tissue B Cells Hye-Jung Kim and Claudia Berek 4. Tracking Antigen Specific CD4+ T Cells with Soluble MHC Molecules John A. Gebe and William W. Kwok 5. Analysis of Antigen Reactive T Cells Clare Alexander, Richard C. Duggleby, Jane C. Goodall, Malgosia K. Matyszak, Natasha Telyatnikova and J.S. Hill Gaston 6. Identification and Manipulation of Antigen Specific T Cells with Artificial Antigen Presenting Cells Eva Koffeman, Elissa Keogh, Mark Klein, Berent Prakken and Salvatore Albani 7. Analysis of Th1/Th2 T Cell Subsets Alla Skapenko and Hendrik Schulze-Koops 8. Analysis of the T Cell Receptor Repertoire of Synovial T Cells Lucy Wedderburn and Douglas J. King 9. The Assessment of T Cell Apoptosis in Synovial Fluid Karim Razza, Dagmar Scheel-Toellner, Janet M. Lord, Arne N. Akbar, Christopher D. Buckley and Mike Salmon 10. Assay of T Cell Contact Dependent Monocyte-Macrophage Functions Danielle Burger and Jean-Michel Dayer 11. Phenotypic and Functional Analysis of Synovial Natural Killer Cells Nicola Dalbeth and Margaret F. C. Callan 12. Identification and Isolation and Synovial Dendritic Cells Allison R Pettit, Lois Cavanagh, Amanda Boyce, Jagadish Padmanabha, Judy Peng and Ranjeny Thomas II. Animal Models of Arthritis 13. The Use of Animal Models for Rheumatoid Arthritis Rikard Holmdahl 14. Collagen Induced Arthritis in Mice Richard O. Williams 15. Collagen Induced Arthritis in Rats Marie M. Griffiths, Grant W. Cannon, Tim Corsi, Van Reese and Kandie Kunzler 16. Collagen Antibody Induced Arthritis (CAIA) Kutty Selva Nandakumar and Rikard Holmdahl 17. Arthritis Induced with Minor Cartilage Proteins Stefan Carlsen, Shemin Lu and Rikard Holmdahl 18. Murine Antigen-Induced Arthritis Wim van den Berg, Leo A. B. Joosten, and Peter L.E.M. van Lent 19. Pristane Induced Arthritis in the Rat Peter Olofsson and Rikard Holmdahl 20. The K/BxN Mouse Model of Inflammatory Arthritis: Theory and Practice Paul Monach, Kimie Hattori, Haochu Huang, Elzbieta Hyatt, Jody Morse1, Linh Nguyen, Adriana Ortiz-Lopez, Hsin-Jung Wu, Diane Mathis, and Christophe Benoist 21. Analysis of Arthritic Lesions in the Del1 Mouse: A Model for OA Anna-Marja Säämänen, Mika Hyttinen and Eero Vuorio III. Application of New Technologies to Define Novel Therapeutic Targets 22. Gene Expression Profiling in Rheumatology Tineke C.M.T. van der Pauw Kraan, Lisa G.M. van Baarsen, Francois Rustenburg, Belinda Baltus, Mike Fero and Cornelis L. Verweij 23. Differential Display Reverse Transcription-Polymerase Chain Reaction (DDRT-PCR) to Identify Novel Biomolecules in Arthritis Research Manir Ali and John D. Isaacs 24. Two-Dimensional Electrophoresis of Proteins Secreted from Articular Cartilage Monika Hermansson, Jeremy Saklatvala and Robin Wait 25. Mapping Lymphocyte Plasma Membrane Proteins: A Proteomic Approach Matthew J. Peirce, Jeremy Saklatvala, Robin Wait and Andrew P. Cope 26. In Vivo Phage Display Selection in the Human/SCID Mouse Chimera Model for Defining Synovial Specific Determinants Lewis Lee, Toby Garrood and Costantino Pitzalis 27. Adenoviral Targeting of Signal Transduction Pathways in Synovial Cell Cultures Alison Davis, Corinne Taylor, Catherine Willetts, Clive Smith and Brian M.J. Foxwell