Synopses & Reviews
The book features current knowledge concerning mechanisms of metastasis, the role of the bone microenvironment in cancer progression, function of inflammatory cytokines in metastasis and osteolysis, the role of osteoblasts, thus offering cellular and molecular findings that affect the search for drugs and lead to translational studies. In addition, it contains chapters on animal models for cancer, the molecular imaging of cancer cells, and bone marrow transplants. There are also chapters on bone pain and current therapeutic approaches to secondary bone cancer (i.e. the use of bisphosphonates, chemotherapy, hormone therapy), of particular relevance to the clinician. Each chapter contains extensive bibliography, tables, diagrams and figures that clarify the skeletal complications in the cellular events that lead to cancer development and progression of disease in bone. Chapters tie insights stemming from molecular and cellular events to the clinical picture, focusing on translation of discoveries in the laboratory to the clinic which helps clinicians better understand the basis of a particular event and basic scientists to appreciate the potential importance of their research. With chapters written by authorities in the field, the book is of interest to academic clinicians, researchers of bone and bone cancers, professional staff of hospitals and pharmaceutical houses, and personnel involved in, and concerned with, cancer care and therapy.
Review
From the reviews: "This book covers the basic science and translational and clinical aspects of bone cancer and bone tumors. ... The target audience is clearly an elite group of clinicians and scientists who are focused on understanding future innovations in the treatment of bone related cancers. ... a great addition to the lab that is studying bone cancers or for the clinician who is actively treating patients with bone cancer. ... the average orthopedist will find in deeper scientifically than is necessary for a general orthopedic practice." (Mark R. Hutchinson, Doody's Review Service, December, 2009) "This book is the fifth volume in the series Topics in Bone Biology. It presents up to date knowledge in the mechanisms of cancer in bone. ... The book is well written, extensively referenced and comprehensive. It has been well edited, and chapters are of a consistent layout. ... The book will make a good addition to a departmental library in any unit managing skeletal cancer." (Robert U. Ashford, European Journal of Orthopaedic Surgery & Traumatology, Vol. 21, 2011)
Synopsis
Covering current knowledge on topics including metastasis mechanism and the role of the bone microenvironment in cancer progression, this text offers cellular and molecular findings that affect the search for drugs and should lead to translational studies.
Synopsis
The fifth in a series of reviews, centered on a single major topic (vol. 1 Bone Formation, vol. 2 Bone Resorption, vol. 3 Engineering of Functional Skeletal Tissues, vol. 4 Osteoarthritis) written by acknowledged authorities in the field, and aimed at researchers, clinicians and others involved in the bone field.
Synopsis
Bone and Cancer is the fifth volume in the series Topics in Bone Biology, edited by Felix Bronner and Mary C. Farach-Carson. This title features current knowledge on mechanisms of metastasis, the role of the bone microenvironment in cancer progression, how inflammatory cytokines function in metastasis and osteolysis, and the role of osteoblasts, thus bringing to the clinician and researcher cellular and molecular findings that affect the search for drugs and lead to translational studies. Each chapter contains an extensive bibliography that permits readers to learn more about specific aspects of the chapter topic. Tables, diagrams and figures illustrate and clarify cellular events that lead to development and progression of cancer in bone. Insights based on cellular and molecular events clarify the clinical picture and may lead to translational research and focused therapy. The chapters, authored by authorities from throughout the world, emphasize how current knowledge can lead to better treatement. Other titles in this series:- Bone Formation Bone Resorption Engineering of Functional Skeletal Tissues Bone and Osteoarthritis
About the Author
Series Editors of Topics in Bone Biology are: Professors Felix Bronner, PhD - University of Connecticut Health Center, Farmington, CT, USA, and Dr Mary C. Farach-Carson, PhD - the Department of Biology, University of Delaware, Newark, DE, USA
Table of Contents
Introduction. Primary and Secondary Bone Cancers: A General Overview.- Blood-Bone Axis and Bone Marrow Microenvironment.- Genetics of Osteosarcoma.- Multiple Myeloma and Other Hematological Malignancies of Bone.- Mechanisms of Metastasis to Bone: The Role of Bone Marrow Endothelium.- Lysophosphatidic Acid: Role in Bone and Bone Cancer.- Role of Bone Microenvironment/Metastatic Niche in Cancer Progression.- Detection and Characterization of Disseminated Tumor Cells Present in Bone Marrow of Cancer Patients.- Molecular Imaging of Cancer Cells Growing in Bone.- Inflammatory Cytokines and Their Role in Bone Metastasis and Osteolysis.- Prostate Cancer Bone Colonization: Osteomimicry in the Bone Niche.- Bone Pain Associated with Cancer Metastasis.- Small Animal Models for the Study of Cancer in Bone.- Hormonal Therapies in Breast and Prostate Cancer: Effects on Bone and the Role of Bisphosphonates.- Therapeutic Approaches to Metastatic Bone Cancer II: Targeted and Non-targeted Systemic Agents.- Role of Allogeneic Bone Marrow Transplant in Cancer Treatment.- Role of Radiosurgery in the Treatment of Bone Localized Cancers.